Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jodi M. Maglich"'
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 439-445 (2009)
The nuclear receptor constitutive androstane receptor (CAR) (NR1I3) regulates hepatic genes involved in xenobiotic detoxification as well as genes involved in energy homeostasis. We provide data that extend the role of CAR to regulation of serum trig
Externí odkaz:
https://doaj.org/article/f182279c0919438ea756a35fb33996fd
Autor:
Robert J. H. Austin, Christopher Patten, Eugene L. Stewart, Simon Taylor, Peter Brown, Christopher M. Yates, Davina C. Angell, Jason A. Holt, Rosemary Z. Sasse, Iain Uings, Ryan P. Trump, Jodi M. Maglich
Publikováno v:
Journal of Medicinal Chemistry. 53:4531-4544
Glucocorticoid receptor (GR) agonists have been used for more than half a century as the most effective treatment of acute and chronic inflammatory conditions despite serious side effects that accompany their extended use that include glucose intoler
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb07fc5821b673f4cbe9d6868b22b50
https://doi.org/10.1021/jm100447c
https://doi.org/10.1021/jm100447c
Autor:
Timothy M. Willson, Joe Watson, John T. Moore, Patrick J. McMillen, Bryan Goodwin, Jodi M. Maglich
Publikováno v:
Journal of Biological Chemistry. 279:19832-19838
The orphan nuclear receptor CAR (NR1I3) has been characterized as a central component in the coordinate response to xenobiotic and endobiotic stress. In this study, we demonstrate that CAR plays a pivotal function in energy homeostasis and establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c8af0f950d0b88486f20194a4c9bae
https://doi.org/10.1074/jbc.m313601200
https://doi.org/10.1074/jbc.m313601200
Autor:
John T. Moore, Diane Hawkins-Brown, Bryan Goodwin, Jodi M. Maglich, Steven A. Kliewer, Catherine M. Stoltz
Publikováno v:
Molecular Pharmacology. 62:638-646
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body against environmental chemicals (xenobiotics). PXR and CAR are activated by a wide range of xenobiotics and regulate cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a8eb91b9d562e6f7111762b743fde0
https://doi.org/10.1124/mol.62.3.638
https://doi.org/10.1124/mol.62.3.638
Autor:
Linda B. Moore, John T. Moore, Timothy M. Willson, Millard H. Lambert, Bruce Wisely, Steven A. Kliewer, D.D. McKee, Jodi M. Maglich
Publikováno v:
Molecular Endocrinology. 16:977-986
The NR1I subfamily of nuclear receptors contains a phylogenetically diverse array of receptors related to the mammalian pregnane X receptor (PXR) (NR1I2) and constitutive androstane receptor (CAR) (NR1I3). We have carried out an extensive comparative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fff253434028bbfc7e82f5aab43e04
https://doi.org/10.1210/mend.16.5.0828
https://doi.org/10.1210/mend.16.5.0828
Autor:
Steven A. Kliewer, Timothy M. Willson, Cristin M. Galardi, Jodi M. Maglich, Bryan Goodwin, Karl Whitney, Michael A. Watson, Joan G. Wilson, Jon L. Collins
Publikováno v:
Journal of Biological Chemistry. 276:43509-43515
The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol. In macrophages, LXR stimulates the transcription of genes encoding transporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23790831147434aa84804b6e421ee41
https://doi.org/10.1074/jbc.m106155200
https://doi.org/10.1074/jbc.m106155200
Publikováno v:
Archives of Oral Biology. 45:159-166
Bone morphogenetic protein-7 (BMP-7) affects differentiation of preosteoblasts enabling the resultant cells to respond optimally to acutely acting regulators. As the phosphoinositide cascade and, particularly, the calcium-mobilizing inositol 1,4,5-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4179e30bd219164f7eff868f5fe04c49
https://doi.org/10.1016/s0003-9969(99)00122-3
https://doi.org/10.1016/s0003-9969(99)00122-3
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 45
Many of the commonly observed reproductive toxicities associated with therapeutic compounds can be traced to a disruption of the steroidogenic pathway. We sought to develop an in vitro assay that would predict reproductive toxicity and be high throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d689721ca53d5d97d7bcd4ec13bb0a
https://pubmed.ncbi.nlm.nih.gov/24434083
https://pubmed.ncbi.nlm.nih.gov/24434083
Autor:
Mark Edelstein, Wieslaw M. Kazmierski, Vanessa Muniz-Medina, Terrence Peter Kenakin, Cristin M. Galardi, Jodi M. Maglich, Stacey A. Jones, Karen Chiswell, Robert G. Ferris, Robert E. Hollingsworth
Publikováno v:
Molecular pharmacology. 75(3)
Six allosteric HIV-1 entry inhibitor modulators of the chemokine (C-C motif) receptor 5 (CCR5) receptor are compared for their potency as inhibitors of HIV-1 entry [infection of human osteosarcoma (HOS) cells and peripheral blood mononuclear cells (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f11ba589a7599832eaa88ee3fb0b2b1
https://pubmed.ncbi.nlm.nih.gov/19064629
https://pubmed.ncbi.nlm.nih.gov/19064629
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 3, Pp 439-445 (2009)
The nuclear receptor constitutive androstane receptor (CAR) (NR1I3) regulates hepatic genes involved in xenobiotic detoxification as well as genes involved in energy homeostasis. We provide data that extend the role of CAR to regulation of serum trig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341e48f2cc8d947ddedc41307e8abfba
https://pubmed.ncbi.nlm.nih.gov/18941143
https://pubmed.ncbi.nlm.nih.gov/18941143