Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jodi Lees"'
Autor:
Valeria Capaci, Lorenzo Bascetta, Marco Fantuz, Galina V. Beznoussenko, Roberta Sommaggio, Valeria Cancila, Andrea Bisso, Elena Campaner, Alexander A. Mironov, Jacek R. Wiśniewski, Luisa Ulloa Severino, Denis Scaini, Fleur Bossi, Jodi Lees, Noa Alon, Ledia Brunga, David Malkin, Silvano Piazza, Licio Collavin, Antonio Rosato, Silvio Bicciato, Claudio Tripodo, Fiamma Mantovani, Giannino Del Sal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essenti
Externí odkaz:
https://doaj.org/article/97f4b2fef7914489a6cce6c57fdc9e48
Autor:
Jiil, Chung, Logine, Negm, Vanessa, Bianchi, Lucie, Stengs, Anirban, Das, Zhihui Amy, Liu, Sumedha, Sudhaman, Melyssa, Aronson, Ledia, Brunga, Melissa, Edwards, Victoria, Forster, Martin, Komosa, Scott, Davidson, Jodi, Lees, Patrick, Tomboc, David, Samuel, Roula, Farah, Anne, Bendel, Jeffrey, Knipstein, Kami Wolfe, Schneider, Agnes, Reschke, Shayna, Zelcer, Alexandra, Zorzi, Robert, McWilliams, William D, Foulkes, Raymond, Bedgood, Lindsay, Peterson, Sara, Rhode, An, Van Damme, Isabelle, Scheers, Sharon, Gardner, Gabriel, Robbins, Magimairajan Issai, Vanan, M Stephen, Meyn, Rebecca, Auer, Brandie, Leach, Carol, Burke, Anita, Villani, David, Malkin, Eric, Bouffet, Annie, Huang, Michael D, Taylor, Carol, Durno, Adam, Shlien, Cynthia, Hawkins, Gad, Getz, Yosef E, Maruvka, Uri, Tabori
Publikováno v:
Journal of Clinical Oncology, (2022)
Journal of Clinical Oncology, Vol. 41, no.4, p. 766-777 (2023)
Journal of Clinical Oncology, Vol. 41, no.4, p. 766-777 (2023)
PURPOSE Diagnosis of Mismatch Repair Deficiency (MMRD) is crucial for tumor management and early detection in patients with the cancer predisposition syndrome constitutional mismatch repair deficiency (CMMRD). Current diagnostic tools are cumbersome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adde6f3a5e0c86ef5cfefac454777ed4
https://pubmed.ncbi.nlm.nih.gov/36240479
https://pubmed.ncbi.nlm.nih.gov/36240479
Autor:
Joshua O. Nash, Federico Comitani, Rose Chami, Sarah Cohen-Gogo, Astra Chang-Schwertschkow, Yael Babichev, Jodi Lees, Noa Alon, Nalan Gokgoz, Stephen Man Yu, Kyoko Yuki, Miranda Lorenti, Zhanqin Liu, Alaina McGoey, Famida Spatare, Bernarld Castro, Kim Tsoi, Hagit Peretz Soroka, Jack Brzezinski, Anita Villani, Albiruni Razak, Abha Gupta, Elizabeth Demicco, Gino Somers, Brendan C. Dickson, Jay S. Wunder, Irene L. Andrulis, David Malkin, Rebecca A. Gladdy, Adam Shlien
Publikováno v:
Clinical Cancer Research. 28:B027-B027
Objectives: Sarcomas are mesodermal cancers of bone and soft tissue of which there are >60 malignant varieties, many of which can be difficult to diagnose or subtype using traditional histopathology. A universal molecular definition of sarcoma types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85b3bd1c4a6b4320b88821efc0923a46
https://doi.org/10.1158/1557-3265.sarcomas22-b027
https://doi.org/10.1158/1557-3265.sarcomas22-b027
Autor:
Antonio Rosato, Noa Alon, Lorenzo Bascetta, Silvio Bicciato, Licio Collavin, Alexander A. Mironov, Giannino Del Sal, Fiamma Mantovani, Luisa Ulloa Severino, Fleur Bossi, Ledia Brunga, Andrea Bisso, Valeria Cancila, Denis Scaini, Galina V. Beznoussenko, Roberta Sommaggio, Jodi Lees, Marco Fantuz, Jacek R. Wiśniewski, Elena Campaner, Claudio Tripodo, Silvano Piazza, Valeria Capaci, David Malkin
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Cell Stress
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Cell Stress
TP53 missense mutations leading to the expression of mutant p53 oncoproteins are frequent driver events during tumorigenesis. p53 mutants promote tumor growth, metastasis and chemoresistance by affecting fundamental cellular pathways and functions. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17bd4233a8015db8b8591d4eba5b5bfb
https://hdl.handle.net/11380/1210405
https://hdl.handle.net/11380/1210405
Autor:
Marc Remke, Donna L. Johnston, Cindy Zhang, Hava Starkman, Uri Tabori, Pedro Castelo-Branco, Irene L. Andrulis, Berivan Baskin, Matthew Mistry, Patricia Rakopoulos, Mark Barszczyk, Noa Alon, Cynthia Elizabeth, Joshua Mangerel, Michael D. Taylor, Jodi Lees, Jack Brzezinski, Nada Jabado, Daniel Picard, Jay S. Wunder, Cynthia Hawkins, Aryeh J. Price, James T. Rutka, Stephen C. Mack, Diana M. Merino, Peter B. Dirks, Jonathan D. Wasserman, Annie Huang, David Malkin, Eric Bouffet, Pawel Buczkowicz
Publikováno v:
Acta neuropathologica. 128(6)
Although telomeres are maintained in most cancers by telomerase activation, a subset of tumors utilize alternative lengthening of telomeres (ALT) to sustain self-renewal capacity. In order to study the prevalence and significance of ALT in childhood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dce173d1241ff1e3c6f8ee7feaf090e
https://pubmed.ncbi.nlm.nih.gov/25315281
https://pubmed.ncbi.nlm.nih.gov/25315281
Publikováno v:
Cancer research. 67(4)
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome frequently associated with germ line TP53 mutations. Unpredictable and disparate age of cancer onset is a major challenge in the management of LFS. Genetic modifiers, including the MDM2-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3683714abdd598120a7597f7e5fcf2c1
https://pubmed.ncbi.nlm.nih.gov/17308077
https://pubmed.ncbi.nlm.nih.gov/17308077
Editor—The Li-Fraumeni syndrome (LFS) is a rare familial cancer syndrome that predisposes gene carriers to the development of diverse early onset malignancies, including soft tissue sarcomas, osteosarcomas, adrenocortical carcinomas, brain tumours,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700eddd4b0d6e3f03a16d91ffd7c792c
https://europepmc.org/articles/PMC1734649/
https://europepmc.org/articles/PMC1734649/
Autor:
David W. Hedley, J. Peter McPherson, Melvin H. Freedman, John C. Reed, Leonardo Salmena, Jodi Lees, Elizabeth Sexsmith, Gerald J. Goldenberg, David Malkin, William Chu, Viengthong Lam
Publikováno v:
Leukemia research. 23(10)
The role of p53 as a determinant of sensitivity of ten childhood acute lymphoblastic leukemia (ALL) cell lines to Adriamycin (ADR) was investigated. ADR-sensitive cell lines were found to have wild-type (wt) p53, whereas resistant cell lines containe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3fe8cf790121f8968d16ca94391c47
https://pubmed.ncbi.nlm.nih.gov/10573131
https://pubmed.ncbi.nlm.nih.gov/10573131
Publikováno v:
Brain research. 612(1-2)
Several peptides (cytokines), viz., interleukin-1 (IL-1), interferon-alpha (IFN-alpha), interleukin-6 (IL-6), tumor necrosis factor (TNF), are formed in response to conditions causing tissue inflammation or damage and are implicated in reactive chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db830e2f87150d2d43b9b2468900e2a
https://pubmed.ncbi.nlm.nih.gov/8330197
https://pubmed.ncbi.nlm.nih.gov/8330197
Publikováno v:
Canadian journal of physiology and pharmacology. 70(12)
Conscious cats were used to examine the effectiveness of the interleukin-1 receptor antagonist against the fever induced by interleukin-1 and endotoxin. Although inactive by itself, the antagonist (three 1-μg bolus injections at 10-min intervals), i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92869914934d30c4634bd1a2b7435360
https://pubmed.ncbi.nlm.nih.gov/1301237
https://pubmed.ncbi.nlm.nih.gov/1301237