Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jodi A. Muscal"'
Autor:
Leo Mascarenhas, Chitose Ogawa, Theodore W. Laetsch, Brenda J. Weigel, Michael W. Bishop, Julie Krystal, Scott C. Borinstein, Emily K. Slotkin, Jodi A. Muscal, Pooja Hingorani, Donna E. Levy, Gary Mo, Ashwin Shahir, Jennifer Wright, Steven G. DuBois
Publikováno v:
Cancer Medicine, Vol 10, Iss 3, Pp 843-856 (2021)
Abstract Olaratumab is a monoclonal antibody that specifically binds to platelet‐derived growth factor receptor alpha (PDGFRα) and blocks receptor activation. We conducted a phase 1 trial to evaluate the safety of olaratumab and determine a recomm
Externí odkaz:
https://doaj.org/article/728f5f60eab94b5f8c5a384248851207
Autor:
Xiao-Nan Li, Jodi A. Muscal, Stacey Berg, Mark G. Qian, Debra Liao, Adekunle M. Adesina, Patricia A. Baxter, Jack M. Su, Holly Lindsay, Sibo Zhao, Frank Y. Lin, Huiyuan Zhang, Yuchen Du, Linna Zhang, Sarah G. Injac, Frank K. Braun, Lin Qi, Mari Kogiso
Purpose: Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (alisertib), an orally available selective inhibitor of Aurora A kinase (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add973a53fa03709cc14fba8c29ebe20
https://doi.org/10.1158/1078-0432.c.6526046
https://doi.org/10.1158/1078-0432.c.6526046
Autor:
Xiao-Nan Li, Jodi A. Muscal, Stacey Berg, Mark G. Qian, Debra Liao, Adekunle M. Adesina, Patricia A. Baxter, Jack M. Su, Holly Lindsay, Sibo Zhao, Frank Y. Lin, Huiyuan Zhang, Yuchen Du, Linna Zhang, Sarah G. Injac, Frank K. Braun, Lin Qi, Mari Kogiso
Supplementary Figure S1-S3 Figure S1. Anti-proliferative effects of MLN8237 on pGBM cell lines. Paired monolayer (Mono) and neurosphere (NS) of IC-4687GBM, IC-3752GBM and ICR0315GBM were seeded at 2,000 cells/well and exposed to MLN8237 (1 - 4,000 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf825c071ffe844120a4e784048d90e
https://doi.org/10.1158/1078-0432.22465520.v1
https://doi.org/10.1158/1078-0432.22465520.v1
Autor:
Bindi Naik-Mathuria, Jodi A. Muscal, Jennifer E. Dietrich, Anoosha Moturu, Kamlesh Kukreja, Lily Cheng
Publikováno v:
Journal of Pediatric and Adolescent Gynecology. 34:876-881
Background : Growing teratoma syndrome is defined as conversion of a metastatic immature tumor to a mature tumor after adjuvant chemotherapy and remains an area of investigation because of its unclear pathogenesis. Because of its risk of malignant tr
Autor:
Gary Mo, Michael W. Bishop, Ashwin Shahir, Pooja Hingorani, Steven G. DuBois, Chitose Ogawa, Julie Krystal, Jodi A. Muscal, Scott C. Borinstein, Jennifer Wright, Brenda J. Weigel, Leo Mascarenhas, Theodore W. Laetsch, Donna E. Levy, Emily K. Slotkin
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 3, Pp 843-856 (2021)
Cancer Medicine, Vol 10, Iss 3, Pp 843-856 (2021)
Olaratumab is a monoclonal antibody that specifically binds to platelet‐derived growth factor receptor alpha (PDGFRα) and blocks receptor activation. We conducted a phase 1 trial to evaluate the safety of olaratumab and determine a recommended dos
Autor:
M. John Hicks, Vijay M. Ravindra, Lucia Ruggieri, Guillermo Aldave, Deborah Schady, Norma M. Quintanilla, Sanjeev A. Vasudevan, Jodi A. Muscal
Publikováno v:
Journal of Neurosurgery: Pediatrics. 25:13-20
Pediatric germ cell tumors (GCTs) are neoplasms that originate from primordial germ cells and, according to their site of presentation, are classified as gonadal or extragonadal. The most common site of extragonadal GCTs in children is the sacrococcy
Publikováno v:
Journal of Pediatric and Adolescent Gynecology. 33:610-612
Background Aromatase inhibitors (AIs) are used for estrogen-modulated conditions. Some borderline ovarian tumors (BOT) express estrogen receptors. We present 2 cases of progression from mucinous cystadenoma to mucinous BOT (mBOT) after prior cystecto
Autor:
Theodore Willis Laetsch, Katherine A. Janeway, Douglas S. Hawkins, Katarzyna Juszczak-Kosela, Jodi Ann Muscal, Anderson B. Collier
Publikováno v:
Journal of Clinical Oncology. 40:TPS11583-TPS11583
TPS11583 Background: Palbociclib (PD-0332991) is a highly selective, reversible, small molecule inhibitor of cyclin-dependent kinases (CDK) 4 and 6, administered orally. Functional dependence of Ewing Sarcoma (EWS) cell lines and tumor xenografts on
Autor:
Kevin E. Fisher, Hyojeong Han, Rajkumar Venkatramani, Angshumoy Roy, Kalyani R. Patel, Kelsey C. Bertrand, Jodi A. Muscal
Publikováno v:
Pediatric bloodcancerREFERENCES. 67(4)
Clear cell sarcoma of the kidney (CCSK) is the second most common malignant pediatric renal tumor. Two of the recurrent somatic alterations reported in CCSK are BCL-6 corepressor (BCOR) internal tandem duplication (ITD) and YWHAE-NUTM2B/E gene fusion
Autor:
Holly Lindsay, Sarah Injac, Stacey L. Berg, Frank K. Braun, Mark G. Qian, Huiyuan Zhang, Xiao-Nan Li, Yuchen Du, Patricia Baxter, Adekunle M. Adesina, Sibo Zhao, Mari Kogiso, Debra Liao, Frank Y. Lin, Jodi A. Muscal, Jack Mf Su, Linna Zhang, Lin Qi
Publikováno v:
Clinical Cancer Research. 24:2159-2170
Purpose: Pediatric glioblastoma multiforme (pGBM) is a highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (alisertib), an orally available selective inhibitor of Aurora A kinase (A