Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jodi, Nunnari"'
Autor:
Yael Elbaz-Alon, Yuting Guo, Nadav Segev, Michal Harel, Daniel E. Quinnell, Tamar Geiger, Ori Avinoam, Dong Li, Jodi Nunnari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Membrane contact sites between organelles have been shown to play important biological roles. Here, the authors show that at the ER, PDZD8 associates with Protrudin and also with Rab7 endosomes and recruits mitochondria to form three-way contacts.
Externí odkaz:
https://doaj.org/article/707039eaf48b40168be3bf1f7653eaa0
Autor:
Maxence Le Vasseur, Jonathan Friedman, Marco Jost, Jiawei Xu, Justin Yamada, Martin Kampmann, Max A Horlbeck, Michelle R Salemi, Brett S Phinney, Jonathan S Weissman, Jodi Nunnari
Publikováno v:
eLife, Vol 10 (2021)
Dysfunction of the mitochondrial electron transport chain (mETC) is a major cause of human mitochondrial diseases. To identify determinants of mETC function, we screened a genome-wide human CRISPRi library under oxidative metabolic conditions with se
Externí odkaz:
https://doaj.org/article/cf05516692bc4a05a17589a4c4200ad1
Autor:
Marina Besprozvannaya, Eamonn Dickson, Hao Li, Kenneth S Ginburg, Donald M Bers, Johan Auwerx, Jodi Nunnari
Publikováno v:
eLife, Vol 7 (2018)
Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis. Previous work demonstrated that the highly conserved yeast Ltc/Lam sterol tr
Externí odkaz:
https://doaj.org/article/60c66a29d1814f5aa383d809ab92c5be
Autor:
Daniel T. Hughes, Karinder K. Brar, Jordan L. Morris, Kelly Subramanian, Shivaani Krishna, Fei Gao, Lara-Sophie Rieder, Joshua Freeman, Heather L. Smith, Rebekkah Jukes-Jones, Jodi Nunnari, Julien Prudent, Adrian J. Butcher, Giovanna R. Mallucci
Widespread repression of protein synthesis rates is a key feature of Endoplasmic Reticulum (ER) stress, mediated by the ER sensor kinase PERK. While select transcripts escape this repression, global translational down-regulation impacts crucial prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1bc9f9aa6542ad6c25ac7f281de58a0
https://doi.org/10.1101/2022.07.24.501280
https://doi.org/10.1101/2022.07.24.501280
Autor:
Tamar Geiger, Yuting Guo, Ori Avinoam, Yael Elbaz-Alon, Dong Li, Michal Harel, Daniel E. Quinnell, Nadav Segev, Jodi Nunnari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Endosomes are compositionally dynamic organelles that regulate signaling, nutrient status and organelle quality by specifying whether material entering the cells will be shuttled back to the cell surface or degraded by the lysosome. Recently, membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95110bf8afb97f7d6f2e487e4481ae52
https://doaj.org/article/707039eaf48b40168be3bf1f7653eaa0
https://doaj.org/article/707039eaf48b40168be3bf1f7653eaa0
Publikováno v:
eLife, Vol 4 (2015)
The conserved MICOS complex functions as a primary determinant of mitochondrial inner membrane structure. We address the organization and functional roles of MICOS and identify two independent MICOS subcomplexes: Mic27/Mic10/Mic12, whose assembly is
Externí odkaz:
https://doaj.org/article/e84e32df819649d093abfcbee86f6a02
Autor:
Maxence Le Vasseur, Thiruchelvi R. Reddy, Brett R. Paulson, Jason D. Russell, Adam Jochem, Samantha C. Lewis, David J. Pagliarini, Kelly Subramanian, Jodi Nunnari, Joshua J. Coon
Publikováno v:
The Journal of Cell Biology
CoQ lipids are built at the mitochondrial inner membrane by a multicomponent pathway. Subramanian et al. reveal that CoQ pathway components assemble via CoQ intermediates into domains at ER–mitochondria contacts, suggesting that CoQ domains functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd7da42065f34515d66ad76cb6001e3
https://doi.org/10.1083/jcb.201808044
https://doi.org/10.1083/jcb.201808044
Autor:
Maxence Le Vasseur, Jonathan Friedman, Marco Jost, Jiawei Xu, Justin Yamada, Martin Kampmann, Max A Horlbeck, Michelle R Salemi, Brett S Phinney, Jonathan S Weissman, Jodi Nunnari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d17e259f423cb940fafe85f634720e
https://doi.org/10.7554/elife.67624.sa2
https://doi.org/10.7554/elife.67624.sa2
Autor:
Jodi Nunnari, Chad Lerner, Shona A. Mookerjee, Eddy Gibbs, Katherine Labbé, Maxence Le Vasseur
Publikováno v:
The Journal of cell biology. 220(11)
Mitochondrial function is integrated with cellular status through the regulation of opposing mitochondrial fusion and division events. Here we uncover a link between mitochondrial dynamics and lipid metabolism by examining the cellular role of mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e74a084783c8db6babf44b80b45fdc
https://pubmed.ncbi.nlm.nih.gov/34586346
https://pubmed.ncbi.nlm.nih.gov/34586346
Autor:
Andrew Murley, Laura L Lackner, Christof Osman, Matthew West, Gia K Voeltz, Peter Walter, Jodi Nunnari
Publikováno v:
eLife, Vol 2 (2013)
Mitochondrial division is important for mitochondrial distribution and function. Recent data have demonstrated that ER–mitochondria contacts mark mitochondrial division sites, but the molecular basis and functions of these contacts are not understo
Externí odkaz:
https://doaj.org/article/afcfbf8868544b1da1f95b827db1e1a3