Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jocyndra A. Wright"'
Autor:
Richard A. Gatti, Jocyndra A. Wright, Sharon N. Teraoka, Aaron R. Quinlan, Meenal Gupta, Xiangfei Liu, Patrick Concannon
Publikováno v:
Human mutationREFERENCES. 42(9)
The study of genetic syndromes characterized by sensitivity to DNA damaging agents has provided important insights into the mechanisms that maintain genome stability and identified novel targets for cancer therapies. Here, we used exome sequencing to
Autor:
Stephen S. Rich, Jocyndra A. Wright, Patrick Concannon, Aaron J. Mackey, Suna Onengut-Gumuscu, Tania Habib, Aaron R. Quinlan, Jane H. Buckner, Yan Ge
Publikováno v:
Diabetes
Despite finding more than 40 risk loci for type 1 diabetes (T1D), the causative variants and genes remain largely unknown. Here, we sought to identify rare deleterious variants of moderate-to-large effects contributing to T1D. We deeply sequenced 301
Autor:
Aaron R. Quinlan, Xiangfei Liu, Jocyndra A. Wright, Patrick Concannon, Xin Huang, Umadevi Paila, Sharon N. Teraoka, Richard A. Gatti
Publikováno v:
International journal of radiation oncology, biology, physics. 100(1)
Purpose Mutations in the gene encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), a bifunctional enzyme that catalyzes the final 2 steps of the purine de novo biosynthetic pathway, were identified in a
Publikováno v:
Oncogene
In response to ionizing radiation, the MRE11/RAD50/NBN complex re-distributes to the sites of DNA double-strand breaks (DSBs) where each of its individual components is phosphorylated by the serine-threonine kinase, ATM. ATM phosphorylation of NBN is
Autor:
Deborah McCurdy, Jennifer M. P. Woo, Jocyndra A. Wright, Umadevi Paila, Christina Brown, S Haghayegh, M Schneider, Aaron R. Quinlan, Nathan T. Martin, Patrick Concannon, Richard A. Gatti, Sharon N. Teraoka, Hailiang Hu, Kotoka Nakamura
Publikováno v:
Cell Death & Disease
The study of rare human syndromes characterized by radiosensitivity has been instrumental in identifying novel proteins and pathways involved in DNA damage responses to ionizing radiation. In the present study, a mutation in mitochondrial poly-A-poly
Autor:
Anh T. Diep, Jaya M. Satagopan, Lene Mellemkjær, Patrick Concannon, Jeanne DeWall, Shan Wei, Jocyndra A. Wright, Shanyan Xue, Irene Orlow, Jørgen H. Olsen, Marinela Capanu, Charles F. Lynch, David Duggan, Susan A. Smith, Leslie Bernstein, Anna M. Chiarelli, Robert W. Haile, Sharon N. Teraoka, Wei Wang, Daniela Seminara, Colin B. Begg, Meghan Woods, Marilyn Stovall, Sharon Teraoka, Jennifer D. Brooks, Xiaolin Liang, Kathleen E. Malone, Daniel O. Stram, Eric R. Olson, Noemi Epstein, Jonine L. Bernstein, John D. Boice, Nianmin Zhou, Robert J. Klein, Anne S. Reiner, S. A. Smith, Evgenia Ter-Karapetova, Esther M. John, Lemuel Navarro, Duncan C. Thomas, Kenneth Offit, Karen M. Cerosaletti, Julia A. Knight, V. Anne Morrison, Roy E. Shore
Ionizing radiation (IR) is a breast carcinogen that induces DNA double-strand breaks (DSBs), and variation in genes involved in the DNA DSB response has been implicated in radiation-induced breast cancer. The Women's Environmental, Cancer, and Radiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccb8be659b08169e7a2d9d90939e228
https://europepmc.org/articles/PMC3240722/
https://europepmc.org/articles/PMC3240722/
Publikováno v:
Scopus-Elsevier
Polymorphism in the germline repertoire of T-cell receptor (TCR) variable α and β (Vα and Vβ) genes could alter the relative abilities of individuals in a population to respond to particular antigens. Variation in the number of germline Vα and V
Autor:
N Bastian, TA Davis, C Zuo, S Yoshimoto, Jocyndra A. Wright, Alfred I. Tauber, WH Orme-Johnson
Publikováno v:
Blood. 75:238-241
Myeloperoxidase (MPO) from human neutrophils has been purified and found to exist in three isoenzymatic forms, resolved by ion exchange chromatography. In addition to differences in subunit size and cellular compartmentalization of the isoenzymes, di
The Atm protein kinase is central to the DNA double-strand break response in mammalian cells. After irradiation, dimeric Atm undergoes autophosphorylation at Ser 1981 and dissociates into active monomers. Atm activation is stimulated by expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16fb8422e4354960c145f8fd2cdefae
https://europepmc.org/articles/PMC1430256/
https://europepmc.org/articles/PMC1430256/
Autor:
Patrick Concannon, Kathleen S. Keegan, Jocyndra A. Wright, Antony M. Carr, Dan Herendeen, Merl F. Hoekstra, Nicola J. Bentley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(13)
In fission yeast, the rad3 gene product plays a critical role in sensing DNA structure defects and activating damage response pathways. A structural homologue of rad3 in humans (ATR) has been identified based on sequence similarity in the protein kin