Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jochen Zuegge"'
Publikováno v:
Quantitative Structure-Activity Relationships. 21:249-256
Current virtual screening applications focus not only on biological activity, but also on additional relevant properties of drug candidates, like absorption, distribution, metabolism, and excretion (ADME). In first-pass virtual screening, these predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6cdfb4db32383942cdea2e16cee836
https://doi.org/10.1002/1521-3838(200208)21:3<249::aid-qsar249>3.0.co
https://doi.org/10.1002/1521-3838(200208)21:3<249::aid-qsar249>3.0.co
Publikováno v:
Gene. 280:19-26
The malaria causing protozoan Plasmodium falciparum contains a vestigal, non-photosynthetic plastid, the apicoplast. Numerous proteins encoded by nuclear genes are targeted to the apicoplast courtesy of N-terminal extensions. With the impending seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b87fc4e910c62d61489b0960733dfd
https://doi.org/10.1016/s0378-1119(01)00776-4
https://doi.org/10.1016/s0378-1119(01)00776-4
Publikováno v:
Clinical Pharmacokinetics. 40:553-563
To perform a comparative quantitative evaluation of the prediction accuracy for human hepatic metabolic clearance of 5 different mathematical models: allometric scaling (multiple species and rat only), physiologically based direct scaling, empirical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efabfbf687397ecb217e7e935e0be70
https://doi.org/10.2165/00003088-200140070-00006
https://doi.org/10.2165/00003088-200140070-00006
Autor:
Olivier Roche, Alexander Alanine, Jochen Zuegge, Gisbert Schneider, Pascal Pflimlin, Gerhard Trube
Publikováno v:
Chembiochem : a European journal of chemical biology. 3(5)
A computer-based method has been developed for prediction of the hERG (human ether-a-go-go related gene) K(+)-channel affinity of low molecular weight compounds. hERG channel blockage is a major concern in drug design, as such blocking agents can cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9abb1d641f74c3b9dbac1b5dc6ccb30
https://pubmed.ncbi.nlm.nih.gov/12007180
https://pubmed.ncbi.nlm.nih.gov/12007180
Autor:
Alexander Alanine, Gutknecht Eva-Maria, Wolfgang von der Saal, Shinji Tsujii, Henri Stalder, Michael Patrick Dillon, Mark Rogers-Evans, Jochen Zuegge, Gisbert Schneider, Manfred Kansy, Wolfgang Guba, Petra Schneider, Eric Brian Sjogren, Paul Gillespie, Gerd Zimmermann, Phil Jones, Olivier Roche, Harris William, Werner Neidhart, Mikio Taniguchi, Franck Danel, Nader Fotouhi, Robert Alan Goodnow, Konrad Bleicher
Publikováno v:
Journal of medicinal chemistry. 45(1)
A computer-based method was developed for rapid and automatic identification of potential "frequent hitters". These compounds show up as hits in many different biological assays covering a wide range of targets. A scoring scheme was elaborated from s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f164d3f2e10fcd31bcbfafcc17ea65b
https://pubmed.ncbi.nlm.nih.gov/11754585
https://pubmed.ncbi.nlm.nih.gov/11754585
Publikováno v:
Journal of molecular graphicsmodelling. 19(3-4)
H-BloX is a web-based JavaScript application that allows the calculation and visualization of Shannon information content or relative entropy (Kullback-Leibler ‘distance’) within sequence alignment blocks. The application was designed for use in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70668898be684a02433ab14671e33f2c
https://pubmed.ncbi.nlm.nih.gov/11449568
https://pubmed.ncbi.nlm.nih.gov/11449568