Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jochen Singer"'
Autor:
Christos Dimitrakopoulos, Sravanth Kumar Hindupur, Marco Colombi, Dritan Liko, Charlotte K. Y. Ng, Salvatore Piscuoglio, Jonas Behr, Ariane L. Moore, Jochen Singer, Hans-Joachim Ruscheweyh, Matthias S. Matter, Dirk Mossmann, Luigi M. Terracciano, Michael N. Hall, Niko Beerenwinkel
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood. Results Here, we explored the effect of defined genetic changes on the transcripto
Externí odkaz:
https://doaj.org/article/224fb61594c44244800fcd87efa2b40b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Cross-cell heterogeneity of genotypes can be revealed by analyzing single-cell sequencing data. Here the authors develop a tool for single-cell variant calling via phylogenetic inference, and use it to analyze cancer genomics datasets.
Externí odkaz:
https://doaj.org/article/c27e9efdc03843eda0fe4c408b3ec786
Autor:
Franziska Singer, Anja Irmisch, Nora C. Toussaint, Linda Grob, Jochen Singer, Thomas Thurnherr, Niko Beerenwinkel, Mitchell P. Levesque, Reinhard Dummer, Luca Quagliata, Sacha I. Rothschild, Andreas Wicki, Christian Beisel, Daniel J. Stekhoven
Publikováno v:
BMC Medical Informatics and Decision Making, Vol 18, Iss 1, Pp 1-18 (2018)
Abstract Background Molecular precision oncology is an emerging practice to improve cancer therapy by decreasing the risk of choosing treatments that lack efficacy or cause adverse events. However, the challenges of integrating molecular profiling in
Externí odkaz:
https://doaj.org/article/fc0a60e3820f4bb481a3a59f28c85971
Autor:
Jürgen Rybak, Anja Kuss, Lamecker Hans, Stefan Zachow, Hans-Christian Hege, Matthias Lienhard, Jochen Singer, Kerstin Neubert, Randolf Menzel
Publikováno v:
Frontiers in Systems Neuroscience, Vol 4 (2010)
The honeybee standard brain (HSB) serves as an interactive tool for relating morphologies of bee brain neurons and provides a reference system for functional and bibliographical properties (http://www.neurobiologie.fu-berlin.de/beebrain/). The ultima
Externí odkaz:
https://doaj.org/article/7ee18da9253144dca6a8710c0c1ca08f
Motivation Tumours evolve as heterogeneous populations of cells, which may be distinguished by different genomic aberrations. The resulting intra-tumour heterogeneity plays an important role in cancer patient relapse and treatment failure, so that ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6b3552029d15a2f2c6fb46b9b6efe2
https://doi.org/10.1101/2022.01.28.478229
https://doi.org/10.1101/2022.01.28.478229
Autor:
Nicola Aceto, Walter P. Weber, Ramona Scherrer, Niko Beerenwinkel, Christian Kurzeder, Julia Landin, Christian Beisel, Marcus Vetter, Francesc Castro-Giner, Jochen Singer, Ilona Krol, Viola Heinzelmann-Schwarz, Barbara Maria Szczerba, Cinzia Donato, Manuel C. Scheidmann, Christoph Rochlitz, Sofia Gkountela
Publikováno v:
Nature. 566:553-557
A better understanding of the features that define the interaction between cancer cells and immune cells is important for the development of new cancer therapies1. However, focus is often given to interactions that occur within the primary tumour and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab5bb07d88737a906850c8f96be9ca3
https://doi.org/10.1038/s41586-019-0915-y
https://doi.org/10.1038/s41586-019-0915-y
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications
Nature Communications, 9 (1)
Nature Communications
Nature Communications, 9 (1)
Reconstructing the evolution of tumors is a key aspect towards the identification of appropriate cancer therapies. The task is challenging because tumors evolve as heterogeneous cell populations. Single-cell sequencing holds the promise of resolving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015cc98bee3fb2ec10645c951de08ade
https://doaj.org/article/c27e9efdc03843eda0fe4c408b3ec786
https://doaj.org/article/c27e9efdc03843eda0fe4c408b3ec786
Autor:
Aashil A. Batavia, Ariane L. Moore, Christian Beisel, Elodie Burcklen, Jack Kuipers, Jochen Singer, Peter Schraml, Holger Moch, Niko Beerenwinkel
Publikováno v:
Cancers, Vol 13, Iss 2163, p 2163 (2021)
Cancers, 13 (9)
Cancers
Volume 13
Issue 9
Cancers, 13 (9)
Cancers
Volume 13
Issue 9
Intra-tumour heterogeneity is the molecular hallmark of renal cancer, and the molecular tumour composition determines the treatment outcome of renal cancer patients. In renal cancer tumourigenesis, in general, different tumour clones evolve over time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d37097fb151ec1c868b80a75b9a50d1
https://www.mdpi.com/2072-6694/13/9/2163
https://www.mdpi.com/2072-6694/13/9/2163
Autor:
Charlotte K.Y. Ng, Salvatore Piscuoglio, Christos Dimitrakopoulos, Jonas Behr, Ariane L. Moore, Dirk Mossmann, Matthias S. Matter, Michael N. Hall, Jochen Singer, Hans-Joachim Ruscheweyh, Marco Colombi, Luigi Terracciano, Sravanth K. Hindupur, Niko Beerenwinkel, Dritan Liko
Publikováno v:
Dimitrakopoulos, Christos; Hindupur, Sravanth Kumar; Colombi, Marco; Liko, Dritan; Ng, Charlotte K Y; Piscuoglio, Salvatore; Behr, Jonas; Moore, Ariane L; Singer, Jochen; Ruscheweyh, Hans-Joachim; Matter, Matthias S; Mossmann, Dirk; Terracciano, Luigi M; Hall, Michael N; Beerenwinkel, Niko (2021). Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma. BMC Genomics, 22(1), p. 592. BioMed Central 10.1186/s12864-021-07876-9
BMC Genomics, 22 (1)
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
BMC Genomics
BMC Genomics, 22 (1)
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
BMC Genomics
Background Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood. Results Here, we explored the effect of defined genetic changes on the transcriptome, prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938b8fc5fa221e2683748db029f17e99
Autor:
Benjamin L. Ebert, Urs Schanz, Mónica S. Ventura Ferreira, Christian Beisel, Christoph Gassner, Beat M. Frey, Tim H. Brümmendorf, Fabian Beier, Niko Beerenwinkel, Radek C. Skoda, Steffen Boettcher, Elise Gourri, Elodie Burcklen, Jochen Singer, Markus G. Manz, C. Matthias Wilk
Publikováno v:
Blood, 135 (18)
Clonal hematopoiesis (CH) is associated with age and an increased risk of myeloid malignancies, cardiovascular risk, and all-cause mortality. We tested for CH in a setting where hematopoietic stem cells (HSCs) of the same individual are exposed to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057c63bca10fc5a17fe2e1e020d39997
https://doi.org/10.5167/uzh-187717
https://doi.org/10.5167/uzh-187717