Výsledky vyhledávání - "Jochen Schuhmacher"

DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours

Autor: Jochen Schuhmacher, Hanwen Zhang, Jean Claude Reubi, Damian Wild, Helmut R. Maecke, Beatrice Waser, Michael Eisenhut

Publikováno v: Zhang, Hanwen; Schuhmacher, Jochen; Waser, Beatrice; Wild, Damian; Eisenhut, Michael; Reubi, Jean Claude; Maecke, Helmut R (2007). DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours. European journal of nuclear medicine and molecular imaging, 34(8), pp. 1198-208. Berlin: Springer 10.1007/s00259-006-0347-4

PURPOSE: We aimed at designing and developing a novel bombesin analogue, DOTA-PEG(4)-BN(7-14) (DOTA-PESIN), with the goal of labelling it with (67/68)Ga and (177)Lu for diagnosis and radionuclide therapy of prostate and other human cancers overexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0f47be250ce65a3eeb74fb46b77331
http://doc.rero.ch/record/316292/files/259_2006_Article_347.pdf

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Stable Expression of Soluble Therapeutic Peptides in Eukaryotic Cells by Multimerisation: Application to the HIV-1 Fusion Inhibitory Peptide C46

Autor: Christian Griesinger, Dorothee von Laer, Jochen Schuhmacher, Jacques H. M. Cohen, Xavier Dervillez, Alexandra Huther, Ursula Dietrich

Publikováno v: ChemMedChem. 1:330-339

A major drawback of therapeutic peptides is their short half-life, which results in the need for multiple applications and high synthesis costs. To overcome this, we established a eukaryotic expression system that allows the stable expression of smal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3505ea978657c06764db79723c80e3a8
https://doi.org/10.1002/cmdc.200500062

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Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo

Autor: Ludwig G. Strauss, Ralf Kinscherf, Jochen Schuhmacher, Johannes Hoffend, Walter Mier, Uwe Haberkorn, Michael Eisenhut, Kerstin Schmidt, Antonia Dimitrakopoulou-Strauss

Publikováno v: Nuclear Medicine and Biology. 32:287-292

Investigations into tumor angiogenesis and antiangiogenic treatment have renewed interest in tumor perfusion. To image tumor blood-pool by PET, suitable tracers are not generally available. In this experimental study, we characterized a 68 Ga-labeled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1b233ad7dd07606c278cc1e908baa2
https://doi.org/10.1016/j.nucmedbio.2005.01.002

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Evaluation of Positron Emission Tomography Imaging Using [68Ga]-DOTA-D Phe1-Tyr3-Octreotide in Comparison to [111In]-DTPAOC SPECT. First Results in Patients with Neuroendocrine Tumors

Autor: Uwe Haberkorn, Jochen Schuhmacher, Helmut R. Mäcke, Marcus Henze, Michael Hofmann, Jörg Kowalski

Publikováno v: Molecular Imaging & Biology. 5:42-48

PURPOSE: [111In]-DTPAOC (Octreoscan®) has been shown to be very useful in the detection of somatostatin receptor (SSTR) positive tumors and their metastases using either conventional scintigraphy or single photon emission computed tomography (SPECT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb909c283473a2ad3023aab0554097f7
https://doi.org/10.1016/s1536-1632(03)00038-6

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Pretargeting of human mammary carcinoma xenografts with bispecific anti-MUC1/anti-Ga chelate antibodies and immunoscintigraphy with PET

Autor: Jochen Schuhmacher, Harald Hauser, J. H. Clorius, S. Kaul, Marcus Henze, Ronald Matys, Gabor Klivényi

Publikováno v: Nuclear Medicine and Biology. 28:821-828

We recently demonstrated the feasibility of combining enhanced tumor-to-tissue contrast and PET imaging for immunoscintigraphic tumor localization in pancreas and colon carcinoma bearing nude mice. Contrast enhancement was obtained with a multistep t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29341300ff08ec86ee7cc1f44c4ebb6d
https://doi.org/10.1016/s0969-8051(01)00246-3

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Treatment of Human B Cell Lymphoma Xenografts with a CD3 × CD19 Diabody and T Cells

Autor: Jochen Schuhmacher, Gerhard Moldenhauer, Oliver Christ, Björn Cochlovius, Sergey Kipriyanov, Marike J. J. G. Stassar, Gudrun Strauß, Melvyn Little

Publikováno v: The Journal of Immunology. 165:888-895

The use of anti-CD3 × antitumor bispecific Abs is an attractive and highly specific approach in cancer therapy. Recombinant Ab technology now provides powerful tools to enhance the potency of such immunotherapeutic constructs. We designed a heterodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3118afd4d41d8798eb784f608d5c2b4a
https://doi.org/10.4049/jimmunol.165.2.888

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Manufacturing Scorecard

Autor: Jochen Schuhmacher

Publikováno v: Zeitschrift für wirtschaftlichen Fabrikbetrieb. 100:460-462

Kurzfassung Jedes Unternehmen benötigt aussagekräftige Kennzahlen, um die Erreichung festgelegter Ziele permanent zu überprüfen, Entscheidungen treffen zu können und Informationen über die Auswirkungen von Veränderungen zu bekommen. Ohne diese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97b867b2fbf9c7e7541fadc84f2403e6
https://doi.org/10.3139/104.100928

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Development of a bispecific monoclonal antibody against a gallium-67 chelate and the human melanoma-associated antigen p97 for potential use in pretargeted immunoscintigraphy

Autor: Margot Zöller, Chezian Somasundaram, Jochen Schuhmacher, Siegfried Matzku

Publikováno v: Cancer Immunology Immunotherapy. 36:337-345

A bispecific monoclonal antibody (bsmAb) has been developed against the human melanoma-associated antigen p97 and an octahedral gallium chelate (Ga-HBED) using the hybrid hybridoma technology. As tetradomas were expected to produce a maximum of ten d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c02050e57fa7d25d74d5276db0d8a0
https://doi.org/10.1007/bf01741173

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Investigations concerning the potential for using1h nmr relaxometry or high-resolution spectroscopy of plasma as a screening test for malignant lung disease

Autor: Jochen Schuhmacher, Dorothea Conrad, Edmund R. Matys, Ivan Zuna, William E. Hull, Harald Hauser, Wolfgang Maier-Borst, J. H. Clorius, Hans G. Manke

Publikováno v: Magnetic Resonance in Medicine. 13:103-132

In 158 plasma samples, obtained from patients with lung carcinoma, lung metastases, and infectious or inflammatory lung diseases and from healthy controls, the NMR relaxation times T1 and T2 of water protons were measured at a resonance frequency of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea35b4be4babe7d9bdfaec7e1c873cf
https://doi.org/10.1002/mrm.1910130111

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Evaluation of the pharmacokinetics of 68Ga-DOTATOC in patients with metastatic neuroendocrine tumours scheduled for 90Y-DOTATOC therapy

Autor: Antonia Dimitrakopoulou-Strauss, Jochen Schuhmacher, Sophia Koukouraki, Ludwig G. Strauss, Nikolaos Karkavitsas, V. Georgoulias, Uwe Haberkorn

Publikováno v: European journal of nuclear medicine and molecular imaging. 33(4)

The purpose of the study was to evaluate the pharmacokinetics of 68Ga-DOTATOC in order to ascertain which parameters have the greatest impact on the global DOTATOC standardised uptake value (SUV), defined as the mean SUV of the last frame of the dyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a03d8b1603d6af518a9d2e968cb29dc
https://pubmed.ncbi.nlm.nih.gov/16437218

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