Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jochen R. Hirsch"'
Publikováno v:
Translational Neuroscience. 2:246-251
Natriuretic peptides (NPs) regulate salt and water homeostasis by inducing natriuresis and diuresis in the kidney. These actions in addition to those via the heart and vascular system play important roles in the regulation of blood pressure. In the c
Autor:
Franziska Theilig, Sebastian Bachmann, Rüdiger W. Veh, Irena Goranova, Semanur Ünsal, Jochen R. Hirsch, Christian Derst, Martin Wieske
Publikováno v:
Cellular Physiology and Biochemistry. 21:063-074
K+-channels fulfill several important functions in the mammalian kidney such as volume regulation, recirculation and secretion of K+ ions, and maintaining the resting potential. In this study we used immunocytochemical methods, in situ hybridization,
Autor:
Bayram Edemir, Ana Velic, Gert Gabriëls, Rita Schröter, Eberhard Schlatter, Jochen R. Hirsch, Sandra Paasche
Publikováno v:
American Journal of Transplantation. 5:1276-1285
Renal transplantation is associated with alterations of tubular functions and of the renin-angiotensin-aldosterone system. The underlying cellular and molecular mechanisms are unclear. We used an allogeneic rat renal transplantation model of acute re
Autor:
Eberhard Schlatter, Bayram Edemir, Ana Velic, Heike Stegemann, Jasmin Bartel, Jochen R. Hirsch, Rita Schröter, Christian August, Regina Thomas, Gert Gabriëls
Publikováno v:
Journal of the American Society of Nephrology. 15:967-977
Kidney transplantation often leads to disturbances of solute and volume maintenance in humans. To investigate underlying mechanisms, expression and function of renal transporters and receptors of the proximal tubule (PT) were analyzed in an acute rej
Autor:
Eberhard Schlatter, Giuliano Ciarimboli, Jochen R. Hirsch, Valentin Gorboulev, Katja Struwe, Petra Arndt, Hermann Koepsell
Publikováno v:
Journal of Cellular Physiology. 201:420-428
The human organic cation transporter type 1 (hOCT1) is an important transport system for small organic cations in the liver. Organic cation transporters are regulated by different signaling pathways, but the regulation of hOCT1 has not yet been studi
Autor:
Eberhard Schlatter, Jochen R. Hirsch
Publikováno v:
Cellular Physiology and Biochemistry. 13:223-228
HEK-293 cells are known to reflect many features of the late distal tubule. Furthermore, they have the ability to release urodilatin, the structural analog to ANP. RT-PCR was performed to test for the
Autor:
Thomas Mehrens, V. Mönnich, Eberhard Schlatter, Giuliano Ciarimboli, C. Popp, Ibrahim Çetinkaya, Hermann Koepsell, Jochen R. Hirsch
Publikováno v:
Journal of Membrane Biology. 189:237-244
The electrogenic cation transporters OCT1 and OCT2 in the basolateral membrane of renal proximal tubules mediate the first step during secretion of organic cations. Previously we demonstrated stimulation and change of selectivity for rat OCT1 (rOCT1)
Autor:
Eberhard Schlatter, Erik Harms, Robert Kleta, Ibrahim Çetinkaya, Peter Herter, Jochen R. Hirsch
Publikováno v:
Journal of the American Society of Nephrology. 13:2085-2093
Cystinosis is the most common cause of the renal Fanconi syndrome in children, leading to severe electrolyte disturbances and growth failure. A defective lysosomal transporter, cystinosin, results in intralysosomal accumulation of cystine. Loading ce
Autor:
Andreas Karschin, Ortrud K. Steinlein, Wenli Gu, Christian Derst, Jochen R. Hirsch, Jürgen Daut, Günter Schlichthörl, Hartmut Engels, Christine Karschin
Publikováno v:
The Journal of Physiology. 539:657-668
Two novel alternatively spliced isoforms of the human two-pore-domain potassium channel TREK-2 were isolated from cDNA libraries of human kidney and fetal brain. The cDNAs of 2438 base pairs (bp) (TREK-2b) and 2559 bp (TREK-2c) encode proteins of 508
Autor:
Eberhard Schlatter, Hans-Jürgen Piechota, Ibrahim Çetinkaya, Gesine Pietig, Jochen R. Hirsch, Thomas Mehrens
Publikováno v:
Journal of Biological Chemistry. 276:33741-33746
The kidney, and more specifically the proximal tubule, is the main site of elimination of cationic endogenous metabolites and xenobiotics. Although numerous studies exist on renal organic cation transport of rat and rabbit, no information is availabl