Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Jochen K. Lennerz"'
Autor:
Jaime L. Schneider, Khvaramze Shaverdashvili, Mari Mino-Kenudson, Subba R. Digumarthy, Andrew Do, Audrey Liu, Justin F. Gainor, Jochen K. Lennerz, Timothy F. Burns, Jessica J. Lin
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-7 (2023)
Abstract Acquired drug resistance remains a major problem across oncogene-addicted cancers. Elucidation of mechanisms of resistance can inform rational treatment strategies for patients relapsing on targeted therapies while offering insights into tum
Externí odkaz:
https://doaj.org/article/39fd463012fa4aa7af342003242f7782
Autor:
Melissa Zhao, Mai Chan Lau, Koichiro Haruki, Juha P. Väyrynen, Carino Gurjao, Sara A. Väyrynen, Andressa Dias Costa, Jennifer Borowsky, Kenji Fujiyoshi, Kota Arima, Tsuyoshi Hamada, Jochen K. Lennerz, Charles S. Fuchs, Reiko Nishihara, Andrew T. Chan, Kimmie Ng, Xuehong Zhang, Jeffrey A. Meyerhardt, Mingyang Song, Molin Wang, Marios Giannakis, Jonathan A. Nowak, Kun-Hsing Yu, Tomotaka Ugai, Shuji Ogino
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)
Abstract Routine tumor-node-metastasis (TNM) staging of colorectal cancer is imperfect in predicting survival due to tumor pathobiological heterogeneity and imprecise assessment of tumor spread. We leveraged Bayesian additive regression trees (BART),
Externí odkaz:
https://doaj.org/article/0d8f3ec5123746e29fb51ae342d20833
Autor:
Ibiayi Dagogo-Jack, MD, Lesli A. Kiedrowski, MS, MPH, Rebecca S. Heist, MD, MPH, Jessica J. Lin, MD, Catherine B. Meador, MD, PhD, Elizabeth A. Krueger, NP, Andrew Do, BS, Jennifer Peterson, BS, Lecia V. Sequist, MD, MPH, Justin F. Gainor, MD, Jochen K. Lennerz, MD, PhD, Subba R. Digumarthy, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 8, Pp 100534- (2023)
Introduction: MET amplification is a potentially actionable resistance mechanism in ALK-rearranged (ALK+) lung cancer. Studies describing treatment outcomes of this molecular subgroup are lacking. Methods: We assembled a cohort of patients with ALK+
Externí odkaz:
https://doaj.org/article/48f3d6a56b8d4f66bc9f438add97a0a8
Autor:
Sumi Piya, Jochen K. Lennerz
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Digital Pathology (DP) and Artificial Intelligence (AI) can be useful in low- and middle-income countries; however, many challenges exist. The United Nations developed sustainable development goals that aim to overcome some of these challenges. The s
Externí odkaz:
https://doaj.org/article/34761f6149ab4665bc9d547401dcb975
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-3 (2022)
Artificial Intelligence (AI) in medicine has grown rapidly, yet few algorithms have been deployed. It is not the problem with the AI itself but with the way functions and results are communicated. Regulatory science provides the appropriate language
Externí odkaz:
https://doaj.org/article/95c562d72df847bc9f1e4c44d79e734c
Autor:
M. Alvaro Berbís, David S. McClintock, Andrey Bychkov, Jeroen Van der Laak, Liron Pantanowitz, Jochen K. Lennerz, Jerome Y. Cheng, Brett Delahunt, Lars Egevad, Catarina Eloy, Alton B. Farris, III, Filippo Fraggetta, Raimundo García del Moral, Douglas J. Hartman, Markus D. Herrmann, Eva Hollemans, Kenneth A. Iczkowski, Aly Karsan, Mark Kriegsmann, Mohamed E. Salama, John H. Sinard, J. Mark Tuthill, Bethany Williams, César Casado-Sánchez, Víctor Sánchez-Turrión, Antonio Luna, José Aneiros-Fernández, Jeanne Shen
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104427- (2023)
Summary: Background: Artificial intelligence (AI) is rapidly fuelling a fundamental transformation in the practice of pathology. However, clinical integration remains challenging, with no AI algorithms to date in routine adoption within typical anato
Externí odkaz:
https://doaj.org/article/4b6861aefe91458ca64e641a24309825
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13309 (2023)
Neurodegenerative diseases, including Alzheimer’s disease (AD), are challenging to diagnose. Currently the field must rely on imperfect diagnostic modalities. A recent study identified differences in several key bio-mechano-physiological parameters
Externí odkaz:
https://doaj.org/article/f83fc101c91b47d8b58c27c61098a430
Autor:
Arielle J. Medford, Lauren Oshry, Baris Boyraz, Lesli Kiedrowski, Sofia Menshikova, Anna Butusova, Charles S. Dai, Tasos Gogakos, Jennifer C. Keenan, Rachel H. Occhiogrosso, Phoebe Ryan, Jochen K. Lennerz, Laura M. Spring, Beverly Moy, Leif W. Ellisen, Aditya Bardia
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Tissue-agnostic indications for targeted therapies have expanded options for patients with advanced solid tumors. The Food and Drug Administration approvals of the programmed death-ligand 1 inhibitor pembrolizumab and the TRK inhibitors larotrectinib
Externí odkaz:
https://doaj.org/article/0f878bea311645418f813ed4267b5a68
Autor:
Tomotaka Ugai, Li Liu, Fred K. Tabung, Tsuyoshi Hamada, Benjamin W. Langworthy, Naohiko Akimoto, Koichiro Haruki, Yasutoshi Takashima, Kazuo Okadome, Hidetaka Kawamura, Melissa Zhao, Seyed Mostafa Mousavi Kahaki, Jonathan N. Glickman, Jochen K. Lennerz, Xuehong Zhang, Andrew T. Chan, Charles S. Fuchs, Mingyang Song, Molin Wang, Kun‐Hsing Yu, Marios Giannakis, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Kana Wu, Shuji Ogino, Edward L. Giovannucci
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background Certain dietary patterns can elicit systemic and intestinal inflammatory responses, which may influence adaptive anti‐tumor immune responses and tumor behavior. We hypothesized that pro‐inflammatory diets might be associated w
Externí odkaz:
https://doaj.org/article/62623fab877348ea82a5bb642d2684fe
Autor:
Esther Abels, Jochen K. Lennerz
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100018- (2022)
Externí odkaz:
https://doaj.org/article/c941fe32ffc84252939c27d33ca63c47