Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Jochen Huehn"'
Autor:
Javier Botey-Bataller, Hedwig D. Vrijmoeth, Jeanine Ursinus, Bart-Jan Kullberg, Cees C. van den Wijngaard, Hadewych ter Hofstede, Ahmed Alaswad, Manoj K. Gupta, Lennart M. Roesner, Jochen Huehn, Thomas Werfel, Thomas F. Schulz, Cheng-Jian Xu, Mihai G. Netea, Joppe W. Hovius, Leo A. B. Joosten, Yang Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine production capacity before an
Externí odkaz:
https://doaj.org/article/e3dcc9f358504f8d8994380adb860b5e
Autor:
Melanie Bühler, Dandan Li, Lin Li, Sandra Runft, Inken Waltl, Andreas Pavlou, Ulrich Kalinke, Malgorzata Ciurkiewicz, Jochen Huehn, Stefan Floess, Andreas Beineke, Wolfgang Baumgärtner, Ingo Gerhauser
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background Theiler’s murine encephalomyelitis virus (TMEV) is a single-stranded RNA virus that causes encephalitis followed by chronic demyelination in SJL mice and spontaneous seizures in C57BL/6 mice. Since earlier studies indicated a cr
Externí odkaz:
https://doaj.org/article/e30bc8fc773a48b2ba2840f704b52b59
Autor:
Tao Yang, Joana Barros-Martins, Ziqing Wang, Melanie Wencker, Jiang Zhang, Justine Smout, Prerna Gambhir, Anika Janssen, Anja Schimrock, Hristo Georgiev, Ximena León-Lara, Siegfried Weiss, Jochen Huehn, Immo Prinz, Andreas Krueger, Reinhold Foerster, Thierry Walzer, Sarina Ravens
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113230- (2023)
Summary: T cell receptor (TCR) Vγ4-expressing γδ T cells comprise interferon γ (IFNγ)- and interleukin-17 (IL-17)-producing effector subsets, with a preference for IL-17 effector fate decisions during early ontogeny. The existence of adult-thymu
Externí odkaz:
https://doaj.org/article/883e2cd2888841afb860c5952de372a1
Autor:
Kevin Baßler, Lisa Schmidleithner, Mehrnoush Hadaddzadeh Shakiba, Tarek Elmzzahi, Maren Köhne, Stefan Floess, Rebekka Scholz, Naganari Ohkura, Timothy Sadlon, Kathrin Klee, Anna Neubauer, Shimon Sakaguchi, Simon C. Barry, Jochen Huehn, Lorenzo Bonaguro, Thomas Ulas, Marc Beyer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD4+ T cells play a central role in the adaptive immune response through their capacity to activate, support and control other immune cells. Although these cells have become the focus of intense research, a comprehensive understanding of the underlyi
Externí odkaz:
https://doaj.org/article/08e3960cd2734ae4aaeb37de7e1fb8d2
Autor:
Joern Pezoldt, Carolin Wiechers, Mangge Zou, Maria Litovchenko, Marjan Biocanin, Michael Beckstette, Katarzyna Sitnik, Martina Palatella, Guido van Mierlo, Wanze Chen, Vincent Gardeux, Stefan Floess, Maria Ebel, Julie Russeil, Panagiota Arampatzi, Ehsan Vafardanejad, Antoine-Emmanuel Saliba, Bart Deplancke, Jochen Huehn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Lymph nodes in various locations of the body differ in their cell composition and gene expression signatures. Here authors show that the rapid postnatal expansion of lymph nodes is governed by CD34 + stromal cells and fibroblastic reticular stromal c
Externí odkaz:
https://doaj.org/article/a6cebd9a2df24f8cacb6093aef1fff24
Autor:
Peggy Riese, Stephanie Trittel, Manas K. Akmatov, Marcus May, Jana Prokein, Thomas Illig, Christoph Schindler, Birgit Sawitzki, Yassin Elfaki, Stefan Floess, Jochen Huehn, Adrian J. Błażejewski, Till Strowig, Esteban A. Hernandez-Vargas, Robert Geffers, Bowen Zhang, Yang Li, Frank Pessler, Carlos A. Guzmán
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Seasonal influenza vaccination is an important strategy to prevent serious disease in the elderly, but individual responsiveness to vaccination widely vary. Here authors establish, with an array of state-of-the art methods, the major immunological pa
Externí odkaz:
https://doaj.org/article/9417193549c440fd81f568927dc6de4e
Autor:
Bowen Zhang, Zhenhua Zhang, Valerie A.C.M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R.M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bošnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Förster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100232- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe COVID-19 in some patients and mild COVID-19 in others. Dysfunctional innate immune responses have been identified to contribute to COVID-19 severity, but th
Externí odkaz:
https://doaj.org/article/1d8a821dff98448fb35c91743f5b812b
Autor:
Kathrin L. Braband, Tamara Kaufmann, Stefan Floess, Mangge Zou, Jochen Huehn, Michael Delacher
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Regulatory T cells in non-lymphoid tissues are not only critical for maintaining self-tolerance, but are also important for promoting organ homeostasis and tissue repair. It is proposed that the generation of tissue Treg cells is a stepwise, multi-si
Externí odkaz:
https://doaj.org/article/914b0a3aab7543979c780dd8986835e0
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 2, Pp 175-188 (2022)
Abstract Background & Aims Thymic conventional dendritic cells (t‑DCs) are crucial for the development of T cells. A substantial fraction of t‑DCs originates extrathymically and migrates to the thymus. Here, these cells contribute to key processe
Externí odkaz:
https://doaj.org/article/0f2d18a72dd84a528f5ec5276f7d3576
Autor:
Joern Pezoldt, Carolin Wiechers, Florian Erhard, Ulfert Rand, Tanja Bulat, Michael Beckstette, Andrea Brendolan, Jochen Huehn, Ulrich Kalinke, Mathias Mueller, Birgit Strobl, Bart Deplancke, Luka Čičin-Šain, Katarzyna M. Sitnik
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Joern Pezoldt et al. analyze mouse spleen fibroblasts using single cell RNA sequencing, revealing 11 distinct clusters of fibroblastic cells or subtypes. Their results collectively provide further insight into the transcriptional identities of spleni
Externí odkaz:
https://doaj.org/article/a39bfb883b614159a6fc0d605a03133d