Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jochen Dahm-Daphi"'
Autor:
Sarah Degenhardt, Kristin Dreffke, Urlike Schötz, Cordula Petersen, Rita Engenhart-Cabillic, Kai Rothkamm, Jochen Dahm-Daphi, Ekkehard Dikomey, Wael Yassin Mansour
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Here, we present a modified in vitro end-joining (EJ) assay to quantify EJ capacity, accuracy as well as pathway switch to alternative end-joining (Alt-EJ) or single strand annealing (SSA). A novel transformation assay was established to specifically
Externí odkaz:
https://doaj.org/article/13fe5a8a9fbf4e18bdc0e72db773ed51
Autor:
Bianca M Sirbu, Sarah J Lachmayer, Verena Wülfing, Lara M Marten, Katie E Clarkson, Linda W Lee, Liliana Gheorghiu, Lee Zou, Simon N Powell, Jochen Dahm-Daphi, Henning Willers
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23053 (2011)
Homologous recombination (HR) is required for the restart of collapsed DNA replication forks and error-free repair of DNA double-strand breaks (DSB). However, unscheduled or hyperactive HR may lead to genomic instability and promote cancer developmen
Externí odkaz:
https://doaj.org/article/120f1d6864584360a2abd10d9302e96a
Autor:
Henning Willers, Jeffrey Settleman, Jochen Dahm-Daphi, Michael Baumann, Ekkehard Dikomey, Mechthild Krause, Malte Kriegs, Cyril Benes, Akash Nanda, Liliana Gheorghiu, David Sander, Fabian Morsbach, Meng Wang
PDF file - 1466KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ce7397c84063c3d4a55f35abfe91ca
https://doi.org/10.1158/0008-5472.22388642
https://doi.org/10.1158/0008-5472.22388642
Autor:
Ulrike Seay, Susann Rudolph, Frank Rose, Niklas Westholt, Sebastian Scheel, Rita Engenhart-Cabillic, Jochen Wilhelm, Julia Fischer, Verena Bill, Werner Seeger, Claudia Fournier, Gisela Taucher-Scholz, Jörg Hänze, Florentine S.B. Subtil, Jochen Dahm-Daphi, Michael Scholz
Publikováno v:
The FASEB Journal. 28:1412-1421
Carbon ion irradiation is an emerging therapeutic option for various tumor entities. Radiation resistance of solid tumors toward photon irradiation is caused by attenuation of DNA damage in less oxygenated tumor areas and by increased hypoxia-inducib
Publikováno v:
Radiotherapy and Oncology. 108:409-414
Purpose DNA replication is a promising target for anti-cancer therapies. Therefore, the understanding of replication-associated DNA repair mechanisms is of great interest. One key factor of DNA double-strand break (DSB) repair is the PIK kinase Ataxi
Publikováno v:
Strahlentherapie und Onkologie. 188:304-307
Autor:
Wael Y. Mansour, Thorsten Rieckmann, Sabrina Köcher, Jochen Dahm-Daphi, Ekkehard Dikomey, Irena Dornreiter, Gabor Rohaly
Publikováno v:
Nucleic Acids Research
Double-strand breaks (DSBs) are repaired by two distinct pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). The endonuclease Artemis and the PIK kinase Ataxia-Telangiectasia Mutated (ATM), mutated in prominent human radios
Autor:
Jochen Dahm-Daphi, Cordula Petersen, Ekkehard Dikomey, G Rohaly, Sabrina Köcher, Malte Kriegs, L Nitsch, Konstantin Hoffer, Thorsten Rieckmann, Irena Dornreiter
Publikováno v:
Oncogene. 32:968-975
Inhibition of homologous recombination (HR) is believed to be a transactivation-independent function of p53 that protects from genetic instability. Misrepair by HR can lead to genetic alterations such as translocations, duplications, insertions and l
Autor:
Ekkehard Dikomey, Ulla Kasten-Pisula, Malte Kriegs, Cordula Petersen, Laura Myllynen, Thorsten Rieckmann, Jochen Dahm-Daphi
Publikováno v:
Radiotherapy and Oncology. 101:147-151
Purpose The purpose of this study was to examine whether the epidermal growth factor receptor (EGFR) may be used as a general target to modulate DNA double strand break (DSB) repair in tumor cells. Material and methods Experiments were performed with
Autor:
Jochen Dahm-Daphi, Jeffrey Settleman, Ekkehard Dikomey, Henning Willers, Fabian Morsbach, Mechthild Krause, Malte Kriegs, Michael Baumann, David Sander, Akash Nanda, Meng Wang, Liliana Gheorghiu, Cyril H. Benes
Publikováno v:
Cancer Research. 71:6261-6269
The mechanisms by which inhibition of the epidermal growth factor receptor (EGFR) sensitizes non–small cell lung cancer (NSCLC) cells to ionizing radiation remain poorly understood. We set out to characterize the radiosensitizing effects of the tyr