Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Jochen B. Geigl"'
Autor:
Qing Zhou, Samantha O. Perakis, Peter Ulz, Sumitra Mohan, Jakob M. Riedl, Emina Talakic, Sigurd Lax, Martin Tötsch, Gerald Hoefler, Thomas Bauernhofer, Martin Pichler, Armin Gerger, Jochen B. Geigl, Ellen Heitzer, Michael R. Speicher
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)
Abstract Background Bevacizumab, a monoclonal antibody against soluble VEGFA, is an approved and commonly administered anti-angiogenic drug in patients with metastasized colorectal cancer (mCRC). The survival benefit of anti-VEGF therapy in mCRC pati
Externí odkaz:
https://doaj.org/article/fc254d7ec85e448b9fbac1d663e3b0b7
Autor:
Peter Ulz, Samantha Perakis, Qing Zhou, Tina Moser, Jelena Belic, Isaac Lazzeri, Albert Wölfler, Armin Zebisch, Armin Gerger, Gunda Pristauz, Edgar Petru, Brandon White, Charles E. S. Roberts, John St. John, Michael G. Schimek, Jochen B. Geigl, Thomas Bauernhofer, Heinz Sill, Christoph Bock, Ellen Heitzer, Michael R. Speicher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Deregulation of transcription factors is frequently observed in cancer. Here, the authors develop a blood-based approach to map transcription factor binding, revealing both patient-specific and tumour-specific aberrations
Externí odkaz:
https://doaj.org/article/dbef1e4364b449e490e94bf709b557cd
Autor:
Peter Ulz, Jelena Belic, Ricarda Graf, Martina Auer, Ingrid Lafer, Katja Fischereder, Gerald Webersinke, Karl Pummer, Herbert Augustin, Martin Pichler, Gerald Hoefler, Thomas Bauernhofer, Jochen B. Geigl, Ellen Heitzer, Michael R. Speicher
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal
Externí odkaz:
https://doaj.org/article/e51914e35344497896933a5afa0a6ac1
Autor:
Peter Ulz, Samantha Perakis, Qing Zhou, Tina Moser, Jelena Belic, Isaac Lazzeri, Albert Wölfler, Armin Zebisch, Armin Gerger, Gunda Pristauz, Edgar Petru, Brandon White, Charles E. S. Roberts, John St. John, Michael G. Schimek, Jochen B. Geigl, Thomas Bauernhofer, Heinz Sill, Christoph Bock, Ellen Heitzer, Michael R. Speicher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f591dc3a55db469bb89412bb54236fc0
Publikováno v:
Case Reports in Medicine, Vol 2012 (2012)
Positive family anamnesis is an important risk factor for cancer, and therefore further investigations need to be done if familial aggregation of cancer is observed. Due to a rare combination of urinary tract and bone tumors occurring in the family p
Externí odkaz:
https://doaj.org/article/b861244dde2044afab596fa90022527d
Autor:
Harry J M Groen, Qing Zhou, Ellen Heitzer, Michael R Speicher, Ed Schuuring, Samantha O Perakis, Sabrina Weber, Ricarda Graf, Sabine Hojas, Jakob M Riedl, Armin Gerger, Nadia Dandachi, Marija Balic, Gerald Hoefler, Jochen B Geigl
Publikováno v:
ESMO Open, Vol 5, Iss 5 (2020)
Objective Precision oncology depends on translating molecular data into therapy recommendations. However, with the growing complexity of next-generation sequencing-based tests, clinical interpretation of somatic genomic mutations has evolved into a f
Externí odkaz:
https://doaj.org/article/98ddadfdad874cbf99c15c5ec5afd03d
Autor:
Michael R. Speicher, Jochen B. Geigl, Thomas Bauernhofer, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Heinz Sill, Florian Eisner, Gerald Höfler, Carolin Lackner, Oliver Mauermann, Julie Waldispuehl-Geigl, Sigurd Lax, Eva Maria Hoffmann, Peter Ulz, Martin Pichler, Christin Gasch, Martina Auer, Ellen Heitzer
PDF file - 868K, Ratio bin distributions for CTC12 (a) and CTC03 (b) from patient #6. The large bin 13 peak indicates the frequency of oligonucleotides with balanced ratio values. The bins to the right of 13 represent the bins for oligonucleotides wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea437c6888af3ac054ca1f47004d381
https://doi.org/10.1158/0008-5472.22398300
https://doi.org/10.1158/0008-5472.22398300
Autor:
Michael R. Speicher, Jochen B. Geigl, Thomas Bauernhofer, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Heinz Sill, Florian Eisner, Gerald Höfler, Carolin Lackner, Oliver Mauermann, Julie Waldispuehl-Geigl, Sigurd Lax, Eva Maria Hoffmann, Peter Ulz, Martin Pichler, Christin Gasch, Martina Auer, Ellen Heitzer
PDF file - 95K, List of 68 genes, which, according to the COSMIC database, are frequently mutated in colorectal carcinoma (CRC) and analyzed in our study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b6d8d30c3e6a4af6e490764f2583e7
https://doi.org/10.1158/0008-5472.22398288
https://doi.org/10.1158/0008-5472.22398288
Autor:
Michael R. Speicher, Jochen B. Geigl, Thomas Bauernhofer, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Heinz Sill, Florian Eisner, Gerald Höfler, Carolin Lackner, Oliver Mauermann, Julie Waldispuehl-Geigl, Sigurd Lax, Eva Maria Hoffmann, Peter Ulz, Martin Pichler, Christin Gasch, Martina Auer, Ellen Heitzer
PDF file - 1303K, Evaluation of available material from patient #9. (a-b) Array CGH profiles of the primary tumor (a) and metastasis (peritoneal carcinomatosis) (b). Regarding the color bar codes please see legend to Supp. Fig. 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734922995c2c4dfe4759f70b2080f593
https://doi.org/10.1158/0008-5472.22398312
https://doi.org/10.1158/0008-5472.22398312
Autor:
Michael R. Speicher, Jochen B. Geigl, Thomas Bauernhofer, Sabine Riethdorf, Klaus Pantel, Hellmut Samonigg, Heinz Sill, Florian Eisner, Gerald Höfler, Carolin Lackner, Oliver Mauermann, Julie Waldispuehl-Geigl, Sigurd Lax, Eva Maria Hoffmann, Peter Ulz, Martin Pichler, Christin Gasch, Martina Auer, Ellen Heitzer
PDF file - 188K, Sequencing of UCR41 and flanking regions: UCR41 is a 217-bp-long ultra-conserved region depicted in dark green. The gray bar indicates the extremely conserved sequence. The region is flanked by two SNPs that are frequent in the Europ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45eb3280c73d66a4f3223c50c208134
https://doi.org/10.1158/0008-5472.22398303.v1
https://doi.org/10.1158/0008-5472.22398303.v1