Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Jochen, Steppan"'
Publikováno v:
Journal of Neuroanaesthesiology and Critical Care, Vol 11, Iss 02, Pp 114-119 (2024)
Vein of Galen malformation (VOGM) is a congenital, intracranial vascular malformation, with an extracardiac shunt. Neonates can present with high output cardiac failure, pulmonary hypertension, or multiorgan failure and are at high risk of perioperat
Externí odkaz:
https://doaj.org/article/725a6d04c30348db8a2c67859a5749a2
Autor:
Rira Choi, Roshini Narayanan, Sandeep Jandu, William Savage, Sara Kang, Bulouere Wodu, Kavitha Nandakumar, Lakshmi Santhanam, Jochen Steppan
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Wire myography to test vasomotor functions of blood vessels ex‐vivo are well‐established for the systemic circulation, however, there is no consensus on protocols for pulmonary arteries. We created a standardized wire myography protocol
Externí odkaz:
https://doaj.org/article/4a8feeadd1064cd6865d1f8f01335e90
Autor:
Jochen Steppan, Kavitha Nandakumar, Huilei Wang, Rosie Jang, Logan Smith, Sara Kang, William Savage, Maria Bauer, Rira Choi, Travis Brady, Bulouere Princess Wodu, Susanna Scafidi, Joseph Scafidi, Lakshmi Santhanam
Publikováno v:
Physiological Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Abstract Hypoxia in the neonatal period is associated with early manifestations of adverse cardiovascular health in adulthood including higher risk of hypertension and atherosclerosis. We hypothesize that this occurs due to activation of lysyl oxidas
Externí odkaz:
https://doaj.org/article/9fe5f4f1fd4f4d71968c9b6b4ce21315
Autor:
Nicolas Philip, Hongyang Pi, Mahin Gadkari, Xin Yun, John Huetsch, Cissy Zhang, Robert Harlan, Aurelie Roux, David Graham, Larissa Shimoda, Anne Le, Scott Visovatti, Peter J. Leary, Sina A. Gharib, Catherine Simpson, Lakshmi Santhanam, Jochen Steppan, Karthik Suresh
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract In pulmonary artery hypertension (PAH), emerging evidence suggests that metabolic abnormalities may be contributing to cellular dysfunction in PAH. Metabolic abnormalities such as glycolytic shift have been observed intracellularly in severa
Externí odkaz:
https://doaj.org/article/97025afab3c44d04bea6835abb15b53e
Autor:
Huilei Wang, James Chen, Sandeep Jandu, Sean Melucci, William Savage, Kavitha Nandakumar, Sara K. Kang, Sebastian Barreto-Ortiz, Alan Poe, Shivam Rastogi, Maria Bauer, Jochen Steppan, Lakshmi Santhanam
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Tissue transglutaminase (TG2), a multifunctional protein of the transglutaminase family, has putative transamidation-independent functions in aging-associated vascular stiffening and dysfunction. Developing preclinical models will be critica
Externí odkaz:
https://doaj.org/article/e5d70fa9ab5a4776b88454e4bd9e5c23
Autor:
Huilei Wang, Alan Poe, Lydia Pak, Kavitha Nandakumar, Sandeep Jandu, Jochen Steppan, Reik Löser, Lakshmi Santhanam
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
To address the limitation of inability to detect lysyl oxidase enzymes (LOX) catalytic function associated with diverse disease processes, Wang et al. developed an in situ activity assay by utilizing the reactivity of hydrazides with imines and carbo
Externí odkaz:
https://doaj.org/article/226aeaa38a774c2ebbf2d0e380dfffce
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/7fcbdc62d3c74310ba7a2ade5ec2a7c1
Autor:
Hussein J. Hassan, Traci Housten, Aparna Balasubramanian, Catherine E. Simpson, Rachel L. Damico, Stephen C. Mathai, Paul M. Hassoun, Jochen Steppan, Peter J. Leary, Todd M. Kolb
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Rationale Pulmonary hypertension (PH) is associated with significant perioperative morbidity and mortality. We hypothesised that pulmonary arterial hypertension (PAH) composite risk assessment scores could estimate perioperative risk for PH patients
Externí odkaz:
https://doaj.org/article/2e789292d7b040519c02e159a979e49c
Publikováno v:
Artery Research, Vol 26, Iss Supplement 1 (2020)
Background: The lower limit of cerebral autoregulation (LLA) refers to the mean blood pressure (BP) below which cerebral blood flow becomes pressure-dependent, resulting, among others, in an increased stroke risk. The LLA measured during cardiac surg
Externí odkaz:
https://doaj.org/article/5769edc3e945481c90d15e7620d6af3f
Autor:
Jochen Steppan, Sandeep Jandu, William Savage, Huilei Wang, Sara Kang, Roshini Narayanan, Daniel Nyhan, Lakshmi Santhanam
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundHypertension is a well-established driver of vascular remodeling and stiffening. The goal of this study was to evaluate whether restoring normal blood pressure (BP) fully restores vascular stiffness toward that of normotensive controls.Meth
Externí odkaz:
https://doaj.org/article/7b714493983f46ceadc1d490e8a965d9