Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Jochen, Hess"'
Autor:
Ofra Novoplansky, Avital B. Shnerb, Divyasree Marripati, Sankar Jagadeeshan, Raghda Abu Shareb, Cristina Conde‐López, Jonathan Zorea, Manu Prasad, Talal Ben Lulu, Ksenia M. Yegodayev, Chen Benafsha, Yushi Li, Dexin Kong, Fengshen Kuo, Luc G. T. Morris, Ina Kurth, Jochen Hess, Moshe Elkabets
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2618-2636 (2023)
Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor trametinib has produced promising results in patients with head and neck squamous cell carcinoma (HNSCC). In the current study, we showed that trametinib treatme
Externí odkaz:
https://doaj.org/article/dfae4467864b4fe58887dab33f08a3c3
Autor:
Sebastian Klein, Nora Wuerdemann, Imke Demers, Christopher Kopp, Jennifer Quantius, Arthur Charpentier, Yuri Tolkach, Klaus Brinker, Shachi Jenny Sharma, Julie George, Jochen Hess, Fabian Stögbauer, Martin Lacko, Marijn Struijlaart, Mari F.C.M. van den Hout, Steffen Wagner, Claus Wittekindt, Christine Langer, Christoph Arens, Reinhard Buettner, Alexander Quaas, Hans Christian Reinhardt, Ernst-Jan Speel, Jens Peter Klussmann
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell cancer (OPSCC) represents an OPSCC subgroup with an overall good prognosis with a rising incidence in Western countries. Multiple lines of evidence suggest that HPV-associate
Externí odkaz:
https://doaj.org/article/f7d0384c46ef4d72a45339eb8dbc1743
Autor:
Karam Khorani, Sebastian Burkart, Christopher Weusthof, Rui Han, Siyuan Liang, Fabian Stögbauer, Jochen Hess
Publikováno v:
Cells, Vol 13, Iss 12, p 1033 (2024)
Recent studies have highlighted neurons and their associated Schwann cells (SCs) as key regulators of cancer development. However, the mode of their interaction with tumor cells or other components of the tumor microenvironment (TME) remains elusive.
Externí odkaz:
https://doaj.org/article/3d4fe573a6be45cba956f4e3c0753184
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/54b4c77185e8488a949dfeae77529985
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the tumor milieu of head and neck squamous cell carcinoma (HNSCC), distinct B cell subpopulations are present, which exert either pro- or anti-tumor activities. Multiple factors, including hypoxia, cytokines, interactions with tumor cells, and oth
Externí odkaz:
https://doaj.org/article/2fdc2fe898464d04b122178442123545
Autor:
Siyuan Liang, Jochen Hess
Publikováno v:
Cells, Vol 13, Iss 3, p 256 (2024)
The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME,
Externí odkaz:
https://doaj.org/article/e70e69b2a0bc4d38bfd4d8b97372d982
Autor:
Barak Rotblat, Andreas Mock, Jerome Fayette, Limor Cohen, Idan Cohen, Elena Voronov, Jebrane Bouaoud, Lucas Michon, Pierre Saintigny, Luc G T Morris, Manu Prasad, Jonathan Zorea, Sankar Jagadeeshan, Avital B Shnerb, Sooraj Mathukkada, Ofra Novoplansky, Mai Badarni, Ksenia M Yegodayev, Sapir Tzadok, Libor Brezina, Andy Karabajakian, Tomer Cooks, Irit Allon, Orr Dimitstein, Benzion Joshua, Dexin Kong, Maurizio Scaltriti, Yaron Carmi, Cristina Conde-Lopez, Jochen Hess, Ina Kurth, Moshe Elkabets
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize the effect o
Externí odkaz:
https://doaj.org/article/e52b0f83da384bc987314eeb1cc6f2e4
Autor:
Julius Moratin, Andreas Mock, Sonja Obradovic, Karl Metzger, Christa Flechtenmacher, Karim Zaoui, Stefan Fröhling, Dirk Jäger, Jürgen Krauss, Jürgen Hoffmann, Kolja Freier, Dominik Horn, Jochen Hess, Christian Freudlsperger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Utilizing digital pathology algorithms for the objective quantification of immunohistochemical staining, this study aimed to identify robust prognostic biomarkers for oral cancer. Tissue microarrays with specimens of a large cohort of oral squamous c
Externí odkaz:
https://doaj.org/article/878ad9c234c84178bc2f6cf9c8d6d9e0
Autor:
Andreas Mock, Michaela Plath, Julius Moratin, Maria Johanna Tapken, Dirk Jäger, Jürgen Krauss, Stefan Fröhling, Jochen Hess, Karim Zaoui
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
While genetic alterations in Epidermal growth factor receptor (EGFR) and PI3K are common in head and neck squamous cell carcinomas (HNSCC), their impact on oncogenic signaling and cancer drug sensitivities remains elusive. To determine their conseque
Externí odkaz:
https://doaj.org/article/457455322d0b483b8198ecc589e06233
Autor:
Sebastian Regnery, Henrik Franke, Thomas Held, Thuy Trinh, Ariel Naveh, Yissachar Abraham, Juliane Hörner‐Rieber, Jochen Hess, Peter E. Huber, Jürgen Debus, Ramon Lopez Perez, Sebastian Adeberg
Publikováno v:
Head & Neck. 45:838-848
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b456fecdf387f07d5b0615ea524fd3
https://doi.org/10.1002/hed.27298
https://doi.org/10.1002/hed.27298