Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Jochen, Buck"'
Autor:
Melanie Balbach, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Carla Ritagliati, Robert W. Myers, David J. Huggins, Clemens Steegborn, Ileana C. Miranda, Peter T. Meinke, Jochen Buck, Lonny R. Levin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Half of all pregnancies are unintended; thus, existing family planning options are inadequate. This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male fert
Externí odkaz:
https://doaj.org/article/95c1debb563241228352ba4e29c74a64
Autor:
Ana Romarowski, Jasna Fejzo, Saman Nayyab, David Martin-Hidalgo, Maria G. Gervasi, Melanie Balbach, Sara Violante, Ana M. Salicioni, Justin Cross, Lonny R. Levin, Jochen Buck, Pablo E. Visconti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian sperm must undergo capacitation to become fertilization-competent. While working on mice, we recently developed a new methodology for treating sperm in vitro, which results in higher rates of fertilization and embryo development after in vi
Externí odkaz:
https://doaj.org/article/6ffc929c917e44778766d6d8e9c7d9a5
Autor:
Melanie Balbach, Lubna Ghanem, Sara Violante, Aye Kyaw, Ana Romarowski, Justin R. Cross, Pablo E. Visconti, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted fr
Externí odkaz:
https://doaj.org/article/bf9504cd7458481db05ef83880ae9942
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and pre
Externí odkaz:
https://doaj.org/article/75032bd9c85b4addbd1c626742696f81
Autor:
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4e985b67c0f441afacd084154e3cbd87
Autor:
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is unique
Externí odkaz:
https://doaj.org/article/79059c54d75b4a94ab021be7ad8ea4df
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbon
Externí odkaz:
https://doaj.org/article/b25fa6c5ab85458d976516b36acbe94e
Autor:
Shan Sun, Makoto Fushimi, Thomas Rossetti, Navpreet Kaur, Jacob Ferreira, Michael Miller, Jonathan Quast, Joop van den Heuvel, Clemens Steegborn, Lonny R. Levin, Jochen Buck, Robert W. Myers, Stacia Kargman, Nigel Liverton, Peter T. Meinke, David J. Huggins
Publikováno v:
Journal of Chemical Information and Modeling. 63:2828-2841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb83927e0a111c0e0b71b25f5a63223d
https://doi.org/10.1021/acs.jcim.2c01577
https://doi.org/10.1021/acs.jcim.2c01577
Autor:
Michael Miller, Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Melanie Balbach, Navpreet Kaur, Lonny R. Levin, Jochen Buck, Maria Kehr, Sandrine Coquille, Joop van den Heuvel, Clemens Steegborn, Makoto Fushimi, Efrat Finkin-Groner, Robert W. Myers, Stacia Kargman, Nigel J. Liverton, David J. Huggins, Peter T. Meinke
Publikováno v:
J Med Chem
Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to successful male fertility: sAC activation is required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1b764b03322568b2d6bccba1a32f50
https://doi.org/10.1021/acs.jmedchem.2c01133
https://doi.org/10.1021/acs.jmedchem.2c01133