Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jochen, Brumm"'
Autor:
Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J. Carter
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Bispecific antibodies, including bispecific IgG, are emerging as an important new class of antibody therapeutics. As a result, we, as well as others, have developed engineering strategies designed to facilitate the efficient production of bispecific
Externí odkaz:
https://doaj.org/article/9805ef0547804dc680ba4370dfa5869f
Autor:
Smadar Shiffman, Edgar A. Rios Piedra, Adeyemi O. Adedeji, Catherine F. Ruff, Rachel N. Andrews, Paula Katavolos, Evan Liu, Ashley Forster, Jochen Brumm, Reina N. Fuji, Ruth Sullivan
Publikováno v:
Journal of Pathology Informatics, Vol 14, Iss , Pp 100333- (2023)
Our objective was to develop an automated deep-learning-based method to evaluate cellularity in rat bone marrow hematoxylin and eosin whole slide images for preclinical safety assessment. We trained a shallow CNN for segmenting marrow, 2 Mask R-CNN m
Externí odkaz:
https://doaj.org/article/1b442b94eac54cee9acfcbaf9141c60f
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Biotherapeutics, which are biologic medications that are natural or bioengineered products of living cells, have revolutionized the treatment of many diseases. However, unwanted immune responses still present a major challenge to their widespread ado
Externí odkaz:
https://doaj.org/article/2642fa906eb74776b1f8dbd262330ea3
Autor:
Sivan Cohen, Shan Chung, Christoph Spiess, Victor Lundin, Eric Stefanich, Steven T. Laing, Vanessa Clark, Jochen Brumm, Ying Zhou, Catherine Huang, Joyce Guerrero, Srividya Myneni, Rajbharan Yadav, Ketevan Siradze, Kun Peng
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Bispecific antibodies (bsAbs) recognize and bind two different targets or two epitopes of the same antigen, making them an attractive diagnostic and treatment modality. Compared to the production of conventional bivalent monospecific antibodies, bsAb
Externí odkaz:
https://doaj.org/article/94fdf7b855084e94b55121a2d490ecd9
Autor:
Rachel Melendez, Benjamin Ordonia, Joyce Guerrero, Azadeh Hassanzadeh, Peter Tran, Justin Low, Manda Wong, Jochen Brumm, Shan Chung, Lynn Kamen
Publikováno v:
Bioanalysis. 14:703-713
Aim: Immunogenicity risk assessment assays are powerful tools that assess the relative immunogenicity of potential biotherapeutics. We detail here the development of a novel assay that measures the degree of antibody internalization by antigen-presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eb2863a5e037d8c5e86185a51608d9
https://doi.org/10.4155/bio-2022-0024
https://doi.org/10.4155/bio-2022-0024
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse
Externí odkaz:
https://doaj.org/article/a4d822c565c54abf9eb7764c43d18ccf
Autor:
Aaron Fullerton, Cyrus Khojasteh, Jonathan Maher, Leah M Norona, Leslie Leung, William R Proctor, Jochen Brumm, Chris Lawson, Tomomi Kiyota
Publikováno v:
Archives of Toxicology. 94:3185-3200
Drug-induced liver injury (DILI) continues to be a major cause of drug attrition and restrictive labeling. Given the importance of farnesoid X receptor (FXR) in bile acid homeostasis, drug-related FXR antagonism may be an important mechanism of DILI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23df1a164eaeb8b44d799fa50ad60907
https://doi.org/10.1007/s00204-020-02804-4
https://doi.org/10.1007/s00204-020-02804-4
Autor:
Steven Piccoli, Devangi Mehta, Alessandra Vitaliti, John Allinson, Shashi Amur, Steve Eck, Cherie Green, Michael Hedrick, Shirley Hopper, Allena Ji, Alison Joyce, Virginia Litwin, Kevin Maher, Joel Mathews, Kun Peng, Afshin Safavi, Yow-Ming Wang, Yan Zhang, Lakshmi Amaravadi, Nisha Palackal, Sai Thankamony, Chris Beaver, Eris Bame, Thomas Emrich, Christine Grimaldi, Jonathan Haulenbeek, Vellalore Kakkanaiah, David Lanham, Andrew Mayer, Paul C Trampont, Laurent Vermet, Naveen Dakappagari, Catherine Fleener, Fabio Garofolo, Cynthia Rogers, Shabnam Tangri, Yuanxin Xu, Meina Liang, Manoj Rajadhyaksha, Susan Richards, Becky Schweighardt, Shobha Purushothama, Daniel Baltrukonis, Jochen Brumm, Elana Cherry, Jason Delcarpini, Carol Gleason, Susan Kirshner, Robert Kubiak, Luying Pan, Michael Partridge, João Pedras-Vasconcelos, Qiang Qu, Venke Skibeli, Therese Solstad Saunders, Roland F Staack, Kay Stubenrauch, Al Torri, Daniela Verthelyi, Haoheng Yan, Boris Gorovits, Rachel Palmer, Mark Milton, Brian Long, Bart Corsaro, Vahid Farrokhi, Michele Fiscella, Neil Henderson, Vibha Jawa, Jim McNally, Rocio Murphy, Hanspeter Waldner, Tong-Yuan Yang
Publikováno v:
Bioanalysis. 11:2207-2244
The 2019 13th Workshop on Recent Issues in Bioanalysis (WRIB) took place in New Orleans, LA, USA on April 1–5, 2019 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d81a589202e4c0b3c30c4ddc1d93790
https://doi.org/10.4155/bio-2019-0271
https://doi.org/10.4155/bio-2019-0271
Autor:
Dana L. Baker, Chris Harp, H-Christian von Büdingen, Teresa Davancaze, Ann Herman, Saloumeh K Fischer, Michael J. Townsend, Robert Hendricks, Jochen Brumm
Publikováno v:
Bioanalysis. 11:1405-1418
Background: Neurofilament light (NfL) chain is an established cerebrospinal fluid (CSF) biomarker for neuroaxonal injury. The highly sensitive Quanterix Simoa™ platform is evaluated for NfL measurement in both CSF and blood. There is a need to link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c506f6575e4067874de04892cb0224d
https://doi.org/10.4155/bio-2019-0163
https://doi.org/10.4155/bio-2019-0163
Autor:
Jochen Brumm, Bradley E. Chipps, Mona Bafadhel, Tmirah Haselkorn, Cecile T.J. Holweg, Ming Yang, Nizar N. Jarjour, William J. Calhoun, Jonathan Corren, Ahmar Iqbal
Publikováno v:
Annals of the American Thoracic Society
Rationale: Blood eosinophil counts are used to inform diagnosis/management of eosinophilic asthma. Objectives: Examine blood eosinophil variability and identify factors affecting eosinophil levels to inform clinical interpretation. Methods: Post hoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48de701e130c6eefcef8fcbf2fedded
https://pubmed.ncbi.nlm.nih.gov/33891831
https://pubmed.ncbi.nlm.nih.gov/33891831