Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jochem Alsenz"'
Autor:
Jochem Alsenz, Patrick Augustijns, Kiyohiko Sugano, German L. Perlovich, Maria Vertzoni, Christos Reppas, Joachim Brouwers, A Müllerz, Cas Bergström, Annette Bauer-Brandl, Christoph Saal
Publikováno v:
Vertzoni, M, Alsenz, J, Augustijns, P, Bauer-Brandl, A, Bergström, C A S, Brouwers, J, Müllerz, A, Perlovich, G, Saal, C, Sugano, K & Reppas, C 2022, ' UNGAP best practice for improving solubility data quality of orally administered drugs ', European Journal of Pharmaceutical Sciences, vol. 168, 106043 . https://doi.org/10.1016/j.ejps.2021.106043
An important goal of the European Cooperation in Science and Technology (COST) Action UNGAP (UNderstanding Gastrointestinal Absorption-related Processes, www.ungap.eu) is to improve standardization of methods relating to the study of oral drug absorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3087eeb872d8d6ef55292a2e780802e
https://pubmed.ncbi.nlm.nih.gov/34662708
https://pubmed.ncbi.nlm.nih.gov/34662708
Autor:
Martin Kuentz, Jochem Alsenz
Publikováno v:
Molecular Pharmaceutics. 16:4661-4669
Lipid-based delivery is a key technology for dealing with the challenges of poorly soluble drugs. Therefore, prediction of drug solubility in lipid-based excipients and their mixtures is an important research goal in computational pharmaceutics. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2e4e38f333ce9d05b6a83e61d905e6
https://doi.org/10.1021/acs.molpharmaceut.9b00801
https://doi.org/10.1021/acs.molpharmaceut.9b00801
Publikováno v:
European Journal of Pharmaceutical Sciences. 87:3-13
This study describes a novel Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for measuring disk intrinsic dissolution rates (DIDR). In MINDISS, compacted mini disks of drugs (2-5mg/disk) are prepared in custom made holders with a surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca941f4130be5e876e339df2189edfa
https://doi.org/10.1016/j.ejps.2015.09.008
https://doi.org/10.1016/j.ejps.2015.09.008
Publikováno v:
Crystal Growth & Design. 15:5002-5010
Hydrate formation of pharmaceutical compounds can affect critical drug properties such as solubility and dissolution. There is, early in development, a need for a deeper understanding of how excipients influence hydrate formation mechanistically. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca625cea59fe9628793d234403f9c9af
https://doi.org/10.1021/acs.cgd.5b00931
https://doi.org/10.1021/acs.cgd.5b00931
Publikováno v:
Molecular pharmaceutics. 15(1)
The methacrylate copolymer Eudragit EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple hydrophobic contacts with polymeric side chains. The latter type of interaction could also pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35acc381f14f6464f9748e3b9c4fee54
https://pubmed.ncbi.nlm.nih.gov/29164891
https://pubmed.ncbi.nlm.nih.gov/29164891
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 125
Recent work demonstrated remarkable solubilization effects of methacrylate-copolymer Eudragit EPO (EPO) not only with acidic drugs but interestingly also with poorly soluble basic compounds. The current work studied EPO-mediated solubilization effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d83eac004f841c69456e361b35ddf1
https://pubmed.ncbi.nlm.nih.gov/29331439
https://pubmed.ncbi.nlm.nih.gov/29331439
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 111
Solubility screening in different surfactant solutions is an important part of pharmaceutical profiling. A particular interest is in low surfactant concentrations that mimic the dilution of an oral dosage form. Despite of intensive previous research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992923f1e55f16a5633fb1398dcf0080
https://pubmed.ncbi.nlm.nih.gov/28943442
https://pubmed.ncbi.nlm.nih.gov/28943442
Publikováno v:
Pharmaceutical development and technology. 23(2)
Self-aggregation of drugs is since many years an important topic in the pharmaceutical sciences. Drugs can aggregate similar to surfactants and thereby exhibit a critical micelle concentration (CMC). The present work focused on amphiphilic drug bases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c594eb18eafe3e47c648cbe380a0e2e
https://pubmed.ncbi.nlm.nih.gov/28378601
https://pubmed.ncbi.nlm.nih.gov/28378601
Publikováno v:
Molecular pharmaceutics. 14(4)
The methacrylate-copolymer Eudragit EPO (EPO) has raised interest in solubility enhancement of anionic drugs. Effects on aqueous drug solubility at rather low polymer concentrations are barely known despite their importance upon dissolution and dilut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735bf41e4364b9860ae6d8e75cf2fbff
https://pubmed.ncbi.nlm.nih.gov/28287743
https://pubmed.ncbi.nlm.nih.gov/28287743