Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jocelynn R Pearl"'
Autor:
Seth A Ament, Jocelynn R Pearl, Jeffrey P Cantle, Robert M Bragg, Peter J Skene, Sydney R Coffey, Dani E Bergey, Vanessa C Wheeler, Marcy E MacDonald, Nitin S Baliga, Jim Rosinski, Leroy E Hood, Jeffrey B Carroll, Nathan D Price
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 3, Pp 1-16 (2018)
Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcri
Externí odkaz:
https://doaj.org/article/37a0a3de07ca4d86ab89638ff4d313a8
Autor:
Matthew S. Wilken, Florian Busch, Zibo Chen, Ryan Kibler, Galen Dods, Vicki H. Wysocki, Christie Ciarlo, Mengxuan Jia, Hanna Liao, Michael C. Jewett, John A. Stamatoyannopoulos, Jocelynn R. Pearl, Basile I. M. Wicky, Shon Green, David Baker, Zachary L. VanAernum, Hana El-Samad, Scott E. Boyken, Andrew Hunt
Publikováno v:
Science
Designer gates Signaling in cells can occur through protein-protein interactions. Chen et al. describe the design of logic gates that can regulate protein association. The gates were built from small, designed proteins that all have a similar structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8ef1f35b344f8981120798e53c38a6
https://doi.org/10.1126/science.aay2790
https://doi.org/10.1126/science.aay2790
Autor:
Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
Publikováno v:
Nature Medicine. 25:1131-1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6
https://doi.org/10.1038/s41591-019-0478-3
https://doi.org/10.1038/s41591-019-0478-3
Autor:
Seth A. Ament, Dani E Bergey, Jeffrey P. Cantle, Jocelynn R. Pearl, Robert M. Bragg, Leroy Hood, Amol C. Shetty, Nathan D. Price, Holly B. Kordasiewicz, Jeffrey B. Carroll, Sydney R. Coffey
SummaryProgressive striatal gene expression changes and epigenetic alterations are a prominent feature of Huntington’s disease (HD), but direct relationships between the huntingtin (HTT) protein and chromatin remain poorly described. Here, using ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e0cb3f112b2fdd6dadad67140db4576
https://doi.org/10.1101/2020.06.04.132571
https://doi.org/10.1101/2020.06.04.132571
Autor:
Sydney R. Coffey, Marcy E. MacDonald, Jeffrey P. Cantle, Jocelynn R. Pearl, Seth A. Ament, Nathan D. Price, Jeffrey B. Carroll, Peter J Skene, Nitin S. Baliga, Leroy Hood, Robert M. Bragg, Dani E Bergey, Jim Rosinski, Vanessa C. Wheeler
Publikováno v:
Molecular Systems Biology
Transcriptional changes occur presymptomatically and throughout Huntington9s disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267eb255bc8c1cf32802eabb97f7f88a
https://doi.org/10.15252/msb.20167435
https://doi.org/10.15252/msb.20167435
Autor:
Paul Shannon, Leroy Hood, Carlo Colantuoni, Bijoya Basu, Cory C. Funk, Alex M. Casella, Nathan D. Price, Jocelynn R. Pearl, Seth A. Ament, Dani E Bergey, Rediet Oshone
Publikováno v:
Cell systems. 8(2)
Summary Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ee52ccd4b67c2cec792fc78727eaa9
https://pubmed.ncbi.nlm.nih.gov/30772379
https://pubmed.ncbi.nlm.nih.gov/30772379
Autor:
Avery Weiss, Laura Heath, Dani E Bergey, Mercy Y. Laurino, John P. Kelly, Nathan D. Price, Corrie O. Smith, Suman Jayadev, Jocelynn R. Pearl, Albert R. LaSpada, Thomas D. Bird
Publikováno v:
Journal of Huntington's disease. 6(3)
Background Huntington's disease (HD) is a fatal progressive neurodegenerative disease characterized by chorea, cognitive impairment and psychiatric symptoms. Retinal examination of HD patients as well as in HD animal models have shown evidence of ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fc85023603734e3c448e221d59595c
https://pubmed.ncbi.nlm.nih.gov/28968243
https://pubmed.ncbi.nlm.nih.gov/28968243
Autor:
Paul Shannon, Carlo Colantuoni, Bijoya Basu, Nathan D. Price, Seth A. Ament, Rediet Oshone, Jocelynn R. Pearl, Leroy Hood, Cory C. Funk, Dani E Bergey
Genetic and genomic studies suggest an important role for transcriptional regulatory changes in brain diseases, but roles for specific transcription factors (TFs) remain poorly understood. We integrated human brain-specific DNase I footprinting and T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6487d42243d50414880974a43870641
https://doi.org/10.1101/190959
https://doi.org/10.1101/190959
Autor:
Bryan, Zeitler, Steven, Froelich, Kimberly, Marlen, David A, Shivak, Qi, Yu, Davis, Li, Jocelynn R, Pearl, Jeffrey C, Miller, Lei, Zhang, David E, Paschon, Sarah J, Hinkley, Irina, Ankoudinova, Stephen, Lam, Dmitry, Guschin, Lexi, Kopan, Jennifer M, Cherone, Hoang-Oanh B, Nguyen, Guijuan, Qiao, Yasaman, Ataei, Matthew C, Mendel, Rainier, Amora, Richard, Surosky, Josee, Laganiere, B Joseph, Vu, Anand, Narayanan, Yalda, Sedaghat, Karsten, Tillack, Christina, Thiede, Annette, Gärtner, Seung, Kwak, Jonathan, Bard, Ladislav, Mrzljak, Larry, Park, Taneli, Heikkinen, Kimmo K, Lehtimäki, Marie M, Svedberg, Jenny, Häggkvist, Lenke, Tari, Miklós, Tóth, Andrea, Varrone, Christer, Halldin, Andrea E, Kudwa, Sylvie, Ramboz, Michelle, Day, Jyothisri, Kondapalli, D James, Surmeier, Fyodor D, Urnov, Philip D, Gregory, Edward J, Rebar, Ignacio, Muñoz-Sanjuán, H Steve, Zhang
Publikováno v:
Nature medicine. 25(7)
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d3620bad8fe21aa64bd37ef53578561
https://pubmed.ncbi.nlm.nih.gov/31263285
https://pubmed.ncbi.nlm.nih.gov/31263285
Autor:
Jocelynn R. Pearl, Philip D. Gregory, Joseph F. Petolino, Tonya L. Strange, Bryan Zeitler, Fyodor D. Urnov, Steve Evans, Ryan C. Blue, David Huizinga, Jianquan Li
Publikováno v:
Plant Biotechnology Journal. 11:671-680
Targeted gene regulation via designed transcription factors has great potential for precise phenotypic modification and acceleration of novel crop trait development. To this end, designed transcriptional activators have been constructed by fusing tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5557e255028eae79b458c18c3dbb25ab
https://doi.org/10.1111/pbi.12057
https://doi.org/10.1111/pbi.12057