Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Jocelyn Yelle"'
1
The Challenges of Poliovirus Eradication
Autor: Jocelyn Yelle
Publikováno v: Journal of Human Virology & Retrovirology. 3
Following the successful efforts to wipe out the virus of Smallpox Variola virus that started in the s and officially realized their goal in the World Health Organization WHO made a commitment in to eradicate Poliovirus and poliomyelitis and achieve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfd677b2a1e9ef900d3cad062ded76d4
https://doi.org/10.15406/jhvrv.2016.03.00102
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2
In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Novel Protease Inhibitor of Human Immunodeficiency Virus Type 1
Autor: Jonathan M. Schapiro, Jocelyn Yelle, Jinzi J. Wu, Serge Dandache, Guy Sevigny, Mark A. Wainberg, Brent Richard Stranix, Neil Parkin
Publikováno v: Antimicrobial Agents and Chemotherapy. 51:4036-4043
At the end of 2005, an estimated 38.6 million people worldwide were living with human immunodeficiency virus (HIV), with approximately 4.1 million cases of new infections and 2.8 million deaths due to AIDS (32). Highly active antiretroviral therapy (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b31f2017c2f07824b79a959fba01ee2
https://doi.org/10.1128/aac.00149-07
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3
Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids
Autor: Guy Sevigny, Valérie Perron, Nicholas LeBerre, Dominik Herbart, Jinzi J. Wu, Jean-François Lavallée, Jocelyn Yelle, Brent Richard Stranix
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:3459-3462
A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec8b05dd2203e20c7342e673032d2e1d
https://doi.org/10.1016/j.bmcl.2006.04.011
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4
Lysine derivatives as potent HIV protease inhibitors. Discovery, synthesis and structure–activity relationship studies
Autor: Abderrahim Bouzide, Jocelyn Yelle, Gilles Sauve
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:1509-1513
A screening assay program on HIV-protease was carried out on more than fifty commercially available N-protected amino acids and has revealed that those with a long side chain such as lysine, ornithine and arginine exhibited significant inhibition of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553e985078bbe4666e7a149e424d97be
https://doi.org/10.1016/j.bmcl.2004.12.068
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6
Is antisense an appropriate nomenclature or design for oligodeoxynucleotides aimed at the inhibition of HIV-1 replication?
Autor: Carole Lavigne, Alain R. Thierry, Gilles Sauve, Jocelyn Yelle
Publikováno v: AAPS PharmSci. 4:34-44
We have evaluated the specificity and the variation in activity against human immunodeficiency virus (HIV) infection of antisense oligodeoxynucleotides (ODNs) with regard to factors such as dose-response range, number and choice of experimental contr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f944a00d10b8bd1caa1a1671dcc1c4
https://doi.org/10.1208/ps040207
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7
The 2014 Ebola Virus Outbreak in West Africa: Current Perspectives for Prevention and Treatment
Autor: Jocelyn Yelle
Publikováno v: Journal of Human Virology & Retrovirology. 1
In 2014, West Africa has been the scene of the worst Ebola virus outbreak in history, with no end in sight [1-4]. This health crisis is reportedly associated with an outlier strain of Zaire Ebola virus [4]. While the first infections were reported in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81d3b492fd3a142dcbecf9e80d7ed768
https://doi.org/10.15406/jhvrv.2014.01.00024
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8
Targeting HIV-1 integrase
Autor: Jocelyn Yelle, Gilles Sauvé, Khampoune Sayasith
Publikováno v: Expert Opinion on Therapeutic Targets. 5:443-464
Human immunodeficiency virus Type 1 (HIV-1) integrase is an essential enzyme for the obligatory integration of the viral DNA into the infected cell chromosome. As no cellular homologue of HIV integrase has been identified, this unique HIV-1 enzyme is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd83d8734eb781574a146145ae9e34
https://doi.org/10.1517/14728222.5.4.443
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10
Low tumorigenicity of canine cells transformed by the human cytomegalovirus
Autor: Gilles Lussier, Claude Hamelin, Albena Pramatarova, Jocelyn Yelle
Publikováno v: Biology of the Cell. 70:9-18
Dog embryo kidney cells transformed by the human cytomegalovirus (HCMV) were obtained after non-permissive infection or transfection with viral DNA digested by restriction endonuclease EcoR I. The transformed cells, growing rapidly and showing an unl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf69df7ef21ea6f7bd8f23735c9514
https://doi.org/10.1016/0248-4900(90)90355-7
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