Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jocelyn Widagdo"'
Autor:
Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda, Tara L. Walker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract The beneficial effects of physical activity on brain ageing are well recognised, with exerkines, factors that are secreted into the circulation in response to exercise, emerging as likely mediators of this response. However, the source and i
Externí odkaz:
https://doaj.org/article/d8e83ff214284a649830da1f3c2ec9ee
Autor:
Jing Zhi Anson Tan, Se Eun Jang, Ana Batallas-Borja, Nishita Bhembre, Mintu Chandra, Lingrui Zhang, Huimin Guo, Mitchell T. Ringuet, Jocelyn Widagdo, Brett M. Collins, Victor Anggono
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113460- (2023)
Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) rec
Externí odkaz:
https://doaj.org/article/4474e4516773492c91d72485b72ad7d7
Autor:
Jocelyn Widagdo, Saumya Udagedara, Nishita Bhembre, Jing Zhi Anson Tan, Lara Neureiter, Jie Huang, Victor Anggono, Mihwa Lee
Publikováno v:
Open Biology, Vol 12, Iss 9 (2022)
Splicing factor proline- and glutamine-rich (SFPQ) is a nuclear RNA-binding protein that is involved in a wide range of physiological processes including neuronal development and homeostasis. However, the mislocalization and cytoplasmic aggregation o
Externí odkaz:
https://doaj.org/article/a29d7e2ad7fb4ee6b2e6110bedc26be9
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One of the major
Externí odkaz:
https://doaj.org/article/f7a7328a03c243f0a468ce0c177e3853
Autor:
Jocelyn Widagdo, Ye Jin Chai, Margreet C. Ridder, Yu Qian Chau, Richard C. Johnson, Pankaj Sah, Richard L. Huganir, Victor Anggono
Publikováno v:
Cell Reports, Vol 10, Iss 5, Pp 783-795 (2015)
AMPA receptors (AMPARs) have recently been shown to undergo post-translational ubiquitination in mammalian neurons. However, the underlying molecular mechanisms are poorly understood and remain controversial. Here, we report that all four AMPAR subun
Externí odkaz:
https://doaj.org/article/58f93ae5adae47d188584b28a26bb7eb
Autor:
Men C. Tan, Jocelyn Widagdo, Yu Q. Chau, Tianyi Zhu, Justin J.-L. Wong, Allen Cheung, Victor Anggono
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Transcription of new RNA is crucial for maintaining synaptic plasticity, learning and memory. Although the importance of synaptic plasticity-related messenger RNAs (mRNAs) is well established, the role of a large group of long non-coding RNAs (lncRNA
Externí odkaz:
https://doaj.org/article/dd4c9fc969e743ea84ea2f2bed5ace3e
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cog
Externí odkaz:
https://doaj.org/article/d7733ef04d874ecd8bb677704603ab55
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49283 (2012)
GTF2IRD1 is one of the genes implicated in Williams-Beuren syndrome, a disease caused by haploinsufficiency of certain dosage-sensitive genes within a hemizygous microdeletion of chromosome 7. GTF2IRD1 is a prime candidate for some of the major featu
Externí odkaz:
https://doaj.org/article/cc747b992ae44ab4931d6407dc917a2f
Autor:
Rowan A. W. Radford, Stephanie L. Rayner, Paulina Szwaja, Marco Morsch, Flora Cheng, Tianyi Zhu, Jocelyn Widagdo, Victor Anggono, Dean L. Pountney, Roger Chung, Albert Lee
Publikováno v:
Journal of Neurochemistry. 165:563-586
Publikováno v:
Seminars in Cell & Developmental Biology. 125:110-121
Activity-dependent gene expression and protein translation underlie the ability of neurons to dynamically adjust their synaptic strength in response to sensory experience and during learning. The emerging field of epitranscriptomics (RNA modification