Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jocelyn Nole"'
Autor:
Robert Hromas, Hyun-Suk Kim, Gurjit Sidhu, Elizabeth Williamson, Aruna Jaiswal, Taylor A. Totterdale, Jocelyn Nole, Suk-Hee Lee, Jac A. Nickoloff, Kimi Y. Kong
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-14 (2017)
Abstract Background Proper repair and restart of stressed replication forks requires intact homologous recombination (HR). HR at stressed replication forks can be initiated by the 5′ endonuclease EEPD1, which cleaves the stalled replication fork. I
Externí odkaz:
https://doaj.org/article/7146ccd319504e488107e7109abda12c
Autor:
Walter Yamada, Sarah Kim, Mohammed Almoslem, Soyoung Kim, Jenny Myrick, Jocelyn Nole, Brandon Duncanson, Arnold Louie, Charles A. Peloquin, Stephan Schmidt, George L. Drusano, Michael Neely
Publikováno v:
Antimicrob Agents Chemother
Mycobacterium tuberculosis (Mtb) exists in various metabolic states, including a nonreplicating persister (NRP) phenotype which may affect response to therapy. We have adopted a model-informed strategy to accelerate discovery of effective Mtb treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19c96cf734417d571e16979ba9d680f
https://doi.org/10.1128/aac.00695-22
https://doi.org/10.1128/aac.00695-22
Autor:
Michael Neely, Charles A. Peloquin, Sarah Parker, Arnold Louie, Jocelyn Nole, Sarah Kim, Stephanie Rogers, Stephan Schmidt, Nino Mtchedlidze, George L. Drusano, Brandon Duncanson, Walter M. Yamada, Meredith Bacci
Publikováno v:
Antimicrob Agents Chemother
Mycobacterium tuberculosis metabolic state affects the response to therapy. Quantifying the effect of antimicrobials in the acid and nonreplicating metabolic phases of M. tuberculosis growth will help to optimize therapy for tuberculosis. As a brute-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bf3fbdd3dce2c1237f048cfe6a3be1
https://doi.org/10.1128/aac.00693-21
https://doi.org/10.1128/aac.00693-21
Autor:
Jocelyn Nole, Arnold Louie, Brandon Duncanson, George L. Drusano, David Brown, Weiguo Liu, Michael Vicchiarelli, Jenny Myrick, Michael Maynard
Publikováno v:
Antimicrob Agents Chemother
Dose-range studies for polymyxin B (PMB) regimens of 0.75 to 12 mg/kg given every 12h (Q12h) were evaluated for bacterial killing and resistance prevention against an AmpC-overexpressing Pseudomonas aeruginosa (PA) and a blaKPC-3-harboring Klebsiella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b341d9b64f39108306f5ea75a27bd7af
https://europepmc.org/articles/PMC8284464/
https://europepmc.org/articles/PMC8284464/
Autor:
Sarah Kim, Arnold Louie, George L. Drusano, Mohammed Almoslem, Soyoung Kim, Jenny Myrick, Jocelyn Nole, Brandon Duncanson, Charles A. Peloquin, Charles A. Scanga, Walter Yamada, Michael Neely, Stephan Schmidt
Publikováno v:
International journal of antimicrobial agents. 59(2)
In recent years, clofazimine (CFZ) has been regaining prominence for the treatment of tuberculosis. However, it shows limited efficacy as a single drug and optimal combination partners have not been identified. Therefore, the objective of our analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51bf589e6be7d0ffe923319c48b86e28
https://pubmed.ncbi.nlm.nih.gov/34958863
https://pubmed.ncbi.nlm.nih.gov/34958863
The Funnel: a Screening Technique for Identifying Optimal Two-Drug Combination Chemotherapy Regimens
Autor:
Charles A. Peloquin, Jocelyn Nole, David Z. D'Argenio, Arnold Louie, Jenny Myrick, Michael Neely, Brandon Duncanson, Stephan Schmidt, Sarah Kim, Mohammed Almoslem, Walter M. Yamada, George L. Drusano, David Brown
Publikováno v:
Antimicrob Agents Chemother
The Mycobacterium tuberculosis drug discovery effort has generated a substantial number of new/repurposed drugs for therapy for this pathogen. The arrival of these drugs is welcome, but another layer of difficulty has emerged. Single agent therapy is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1fe8916e66400128d98f2ddb119da5
https://europepmc.org/articles/PMC7848982/
https://europepmc.org/articles/PMC7848982/
Autor:
Walter M. Yamada, Jocelyn Nole, Nino Mtchedlidze, George L. Drusano, Michael Neely, Sarah Kim, Arnold Louie, Stephan Schmidt, Charles A. Peloquin, Brandon Duncanson
Publikováno v:
Antimicrob Agents Chemother
Multidrug therapy is often required. Examples include antiviral therapy, nosocomial infections, and, most commonly, anti-Mycobacterium tuberculosis therapy. Our laboratory previously identified a mathematical approach to identify 2-drug regimens with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8256e67cb03c55f65ef95c0fad3a346d
https://pubmed.ncbi.nlm.nih.gov/32900682
https://pubmed.ncbi.nlm.nih.gov/32900682
Autor:
Jocelyn Nole, Amirhossein Hajihosseini, Carolina de Miranda Silva, Arnold Louie, Jenny Myrick, George L. Drusano, Stephan Schmidt
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Combination therapy is a successful approach to treat tuberculosis in patients with susceptible strains of Mycobacterium tuberculosis However, the emergence of resistant strains requires identification of new, effective therapies. Pretomanid (PA824)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc38aa42f49c278a315a2267420d5f0
https://doi.org/10.1128/aac.01695-18
https://doi.org/10.1128/aac.01695-18
Autor:
Brandon Duncanson, Jocelyn Nole, Charles A. Peloquin, David Brown, Stephan Schmidt, Charles A. Scanga, Jenny Myrick, Michael Maynard, Arnold Louie, Michael Neely, George L. Drusano
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
A major goal for improving tuberculosis therapy is to identify drug regimens with improved efficacy and shorter treatment durations. Shorter therapies improve patient adherence to the antibiotic regimens that, in turn, decreases resistance emergence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3521102a3a4f86ccbb5200e45790d20
https://doi.org/10.1128/aac.01470-18
https://doi.org/10.1128/aac.01470-18
Autor:
Carolina, de Miranda Silva, Amirhossein, Hajihosseini, Jenny, Myrick, Jocelyn, Nole, Arnold, Louie, Stephan, Schmidt, George L, Drusano
Publikováno v:
Antimicrobial agents and chemotherapy. 63(1)
Combination therapy is a successful approach to treat tuberculosis in patients with susceptible strains of Mycobacterium tuberculosis. However, the emergence of resistant strains requires identification of new, effective therapies. Pretomanid (PA824)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b27aa3913218e6824131079a8669ff65
https://pubmed.ncbi.nlm.nih.gov/30397058
https://pubmed.ncbi.nlm.nih.gov/30397058