Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jocelyn F Krey"'
Autor:
Jocelyn F Krey, Paroma Chatterjee, Julia Halford, Christopher L Cunningham, Benjamin J Perrin, Peter G Barr-Gillespie
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3001964 (2023)
Assembly of the hair bundle, the sensory organelle of the inner ear, depends on differential growth of actin-based stereocilia. Separate rows of stereocilia, labeled 1 through 3 from tallest to shortest, lengthen or shorten during discrete time inter
Externí odkaz:
https://doaj.org/article/440e5a05d7284be28e2aa50c2c5407a5
Autor:
Ying Zhu, Mirko Scheibinger, Daniel Christian Ellwanger, Jocelyn F Krey, Dongseok Choi, Ryan T Kelly, Stefan Heller, Peter G Barr-Gillespie
Publikováno v:
eLife, Vol 8 (2019)
Hearing and balance rely on small sensory hair cells that reside in the inner ear. To explore dynamic changes in the abundant proteins present in differentiating hair cells, we used nanoliter-scale shotgun mass spectrometry of single cells, each ~1 p
Externí odkaz:
https://doaj.org/article/19e6a3669263492e9fe408c93b8d336a
Autor:
Timothy Erickson, Clive P Morgan, Jennifer Olt, Katherine Hardy, Elisabeth Busch-Nentwich, Reo Maeda, Rachel Clemens, Jocelyn F Krey, Alex Nechiporuk, Peter G Barr-Gillespie, Walter Marcotti, Teresa Nicolson
Publikováno v:
eLife, Vol 6 (2017)
Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestib
Externí odkaz:
https://doaj.org/article/8c67b3aa4fc342c1bcf127fb9e97b312
Autor:
Clive P Morgan, Jocelyn F Krey, M'hamed Grati, Bo Zhao, Shannon Fallen, Abhiraami Kannan-Sundhari, Xue Zhong Liu, Dongseok Choi, Ulrich Müller, Peter G Barr-Gillespie
Publikováno v:
eLife, Vol 5 (2016)
While more than 70 genes have been linked to deafness, most of which are expressed in mechanosensory hair cells of the inner ear, a challenge has been to link these genes into molecular pathways. One example is Myo7a (myosin VIIA), in which deafness
Externí odkaz:
https://doaj.org/article/3e65b5e5353b40bf98ff63ca95741554
Autor:
Vladimir Vartanian, Jocelyn F. Krey, Paroma Chatterjee, Sherri M. Jones, Allison Curtis, Renee Ryals, R. Stephen Lloyd, Peter G. Barr-Gillespie
Strategies to reveal the discovery of the relationships between novel phenotypic behaviors and specific genetic alterations can be achieved via either target-specific, directed mutagenesis or phenotypic selection following random chemical mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16187f36244b5daed525783bd6d6b47b
https://doi.org/10.1101/2023.02.28.529432
https://doi.org/10.1101/2023.02.28.529432
Autor:
Seham Ebrahim, Matthew R. Avenarius, M’hamed Grati, Jocelyn F. Krey, Alanna M. Windsor, Aurea D. Sousa, Angela Ballesteros, Runjia Cui, Bryan A. Millis, Felipe T. Salles, Michelle A. Baird, Michael W. Davidson, Sherri M. Jones, Dongseok Choi, Lijin Dong, Manmeet H. Raval, Christopher M. Yengo, Peter G. Barr-Gillespie, Bechara Kachar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both
Externí odkaz:
https://doaj.org/article/42f55193d572437c9f31dff7d2836595
Autor:
Jocelyn F. Krey, Chang Liu, Inna A. Belyantseva, Michael Bateschell, Rachel A. Dumont, Jennifer Goldsmith, Paroma Chatterjee, Rachel S. Morrill, Lev M. Fedorov, Sarah Foster, Jinkyung Kim, Alfred L. Nuttall, Sherri M. Jones, Dongseok Choi, Thomas B. Friedman, Anthony J. Ricci, Bo Zhao, Peter G. Barr-Gillespie
Publikováno v:
The Journal of cell biology. 221(4)
The stereocilia rootlet is a key structure in vertebrate hair cells, anchoring stereocilia firmly into the cell’s cuticular plate and protecting them from overstimulation. Using superresolution microscopy, we show that the ankyrin-repeat protein AN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7f74bf499799fe0bab44edde13fdd9
https://pubmed.ncbi.nlm.nih.gov/35175278
https://pubmed.ncbi.nlm.nih.gov/35175278
Autor:
Seham Ebrahim, Matthew R. Avenarius, M’hamed Grati, Jocelyn F. Krey, Alanna M. Windsor, Aurea D. Sousa, Angela Ballesteros, Runjia Cui, Bryan A. Millis, Felipe T. Salles, Michelle A. Baird, Michael W. Davidson, Sherri M. Jones, Dongseok Choi, Lijin Dong, Manmeet H. Raval, Christopher M. Yengo, Peter G. Barr-Gillespie, Bechara Kachar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7 Article number: 10833 (2016). Published 1 March 2016; Updated 14 August 2017 Technical support for this Article was not fully acknowledged. The Acknowledgements should have included the following: We thank Drs Ronald Petralia
Externí odkaz:
https://doaj.org/article/7ab50f15fa284f74870f3ed28d5085a5
Autor:
Brian Ng, Zoltan Metlagel, Salim Sazzed, Manfred Auer, Peter G. Barr-Gillespie, Willy Wriggers, Julio A. Kovacs, Jing He, Linshanshan Wang, Junha Song, Roma Patterson, Jocelyn F. Krey, Samantha Hao
Publikováno v:
J Struct Biol
Electron cryo-tomography allows for high-resolution imaging of stereocilia in their native state. Because their actin filaments have a higher degree of order, we imaged stereocilia from mice lacking the actin crosslinker plastin 1 (PLS1). We found th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3036f4cddfea85a4b6f3e4686fb343
https://europepmc.org/articles/PMC7067663/
https://europepmc.org/articles/PMC7067663/
Autor:
Kenneth R. Johnson, P.A. Wilmarth, Jocelyn F. Krey, Larry L. David, Peter G. Barr-Gillespie, Rachel A. Dumont
Publikováno v:
The Journal of Neuroscience. 38:843-857
Sensory hair cells require control of physical properties of their apical plasma membranes for normal development and function. Members of the ADP-ribosylation factor (ARF) small GTPase family regulate membrane trafficking and cytoskeletal assembly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364b7762f601b60b3163960451c26b6c
https://doi.org/10.1523/jneurosci.2658-17.2017
https://doi.org/10.1523/jneurosci.2658-17.2017