Výsledky vyhledávání - "Jocelyn C. Mauna"

Akademický článek

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility

Autor: Amanda M. Gleixner, Brandie Morris Verdone, Charlton G. Otte, Eric N. Anderson, Nandini Ramesh, Olivia R. Shapiro, Jenna R. Gale, Jocelyn C. Mauna, Jacob R. Mann, Katie E. Copley, Elizabeth L. Daley, Juan A. Ortega, Maria Elena Cicardi, Evangelos Kiskinis, Julia Kofler, Udai B. Pandey, Davide Trotti, Christopher J. Donnelly

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

ALS and FTLD are both characterized by insoluble cytoplasmic depositions of TDP43. Here the authors show that the nucleopore protein NUP62 is mislocalized in C9orf72 and sporadic ALS/FTLD and propose that it interacts with TDP-43 to promote its insol

Externí odkaz: https://doaj.org/article/04c38fed278645e2a4a1f52a4ea229f4

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NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility

Publikováno v: Nature communications. 13(1)

A G4C2 hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of ALS and FTLD (C9-ALS/FTLD) with cytoplasmic TDP-43 inclusions observed in regions of neurodegeneration. The accumulation of repetitive RNAs and dipeptide r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a6fbcb07c2038150c77fd4f9a3a4c8
https://pubmed.ncbi.nlm.nih.gov/35697676

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G protein βγ subunits play a critical role in the actions of amphetamine

Autor: Caitlyn M. Edwards, M Terminel, S S Harris, Michael R. DeChellis-Marks, Macarena Vergara, Jose A. Pino, C D Bassi, Ramón Sotomayor-Zárate, F G Guajardo, Tracy Baust, Gonzalo E. Torres, Jocelyn C. Mauna, Susan G. Amara, Edda Thiels, Edward Castañeda, Jennie Garcia-Olivares

Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019)
Translational Psychiatry

Abnormal levels of dopamine (DA) are thought to contribute to several neurological and psychiatric disorders including drug addiction. Extracellular DA levels are regulated primarily via reuptake by the DA transporter (DAT). Amphetamine, a potent psy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4dc46e37a1b71e05ae68c1f4db7408
https://doi.org/10.1038/s41398-019-0387-8

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RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

Autor: Patrick G. Needham, Jacob R. Mann, Amantha Thathiah, Michael R. DeChellis-Marks, Amanda M. Gleixner, Bede Portz, Udai Bhan Pandey, Zachary P. Wills, Jocelyn C. Mauna, Lin Guo, Katie E. Copley, Bryan Hurtle, Julia Kofler, Jeffrey L. Brodsky, Christopher B. Calder, Noah J. Pyles, Christopher J. Donnelly, James Shorter, Edward Gomes

Publikováno v: Neuron. 102:321-338.e8

TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within degenerating regions of patient postmortem tissue. The mechanism by which TDP-43 aggr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1450237c19df9f85b5051e1e563388ec
https://doi.org/10.1016/j.neuron.2019.01.048

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Appetitive cue-evoked ERK signaling in the nucleus accumbens requires NMDA and D1 dopamine receptor activation and regulates CREB phosphorylation

Autor: Cory M. Willis, Rebecca L. Foster, Jocelyn C. Mauna, Edda Thiels, Amanda M. Chipman, Erin K. Kirschmann

Conditioned stimuli (CS) can modulate reward-seeking behavior. This modulatory effect can be maladaptive and has been implicated in excessive reward seeking and relapse to drug addiction. We previously demonstrated that exposure to an appetitive CS c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e47d0dc6105283535dc8f9902ab813e
https://europepmc.org/articles/PMC4201811/

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Protein phosphatases 1 and 2A are both required for long-term depression and associated dephosphorylation of cAMP response element binding protein in hippocampal area CA1 in vivo

Autor: Jocelyn C. Mauna, Takeaki Miyamae, Benjamin Pulli, Edda Thiels

Publikováno v: Hippocampus. 21(10)

Evidence shows that the serine/threonine protein phosphatase 1 (PP1) plays a critical role in synaptic plasticity and memory. Little is known about the contribution of the serine/threonine protein phosphatase 2A (PP2A) to synaptic plasticity. Both pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c563625201bfe26123933038526773
https://pubmed.ncbi.nlm.nih.gov/20824729

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Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons

Autor: German Barrionuevo, Edda Thiels, Stephen D. Meriney, Kathleen E. Cosgrove, Jocelyn C. Mauna, J. P. Card, Emilio J. Galván

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(8)

Hippocampal mossy fiber (MF) synapses on area CA3 lacunosum-moleculare (L-M) interneurons are capable of undergoing a Hebbian form of NMDA receptor (NMDAR)-independent long-term potentiation (LTP) induced by the same type of high-frequency stimulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475cf0ad2a8484f33ab8299bf03ede98
https://pubmed.ncbi.nlm.nih.gov/20181582

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Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons

Autor: Oscar M. Lazo, Francisca C. Bronfman, Nibaldo C. Inestrosa, Claudia Pissani, Jocelyn C. Mauna

Publikováno v: Molecular Neurodegeneration, Vol 5, Iss 1, p 5 (2010)
MOLECULAR NEURODEGENERATION
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Molecular Neurodegeneration

Background Septal cholinergic neurons account for most of the cholinergic innervations of the hippocampus, playing a key role in the regulation of hippocampal synaptic activity. Disruption of the septo-hippocampal pathway by an experimental transecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45258d7d977d0016331109b2c788e1b2
http://www.molecularneurodegeneration.com/content/5/1/5

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Cue-elicited reward-seeking requires extracellular signal-regulated kinase activation in the nucleus accumbens

Autor: Jocelyn C. Mauna, Eloise Peet, Michael W. Shiflett, Ross P. Martini, Rebecca L. Foster, Edda Thiels

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(6)

The motivation to seek out rewards can come under the control of stimuli associated with reward delivery. The ability of cues to motivate reward-seeking behavior depends on the nucleus accumbens (NAcc). The molecular mechanisms in the NAcc that under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61bef99bdf5efa0bc3e2c0789709ebc
https://pubmed.ncbi.nlm.nih.gov/18434506

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