Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jocelyn A. Schroeder"'
Autor:
Yuanhua Cai, Jocelyn A. Schroeder, Weiqing Jing, Cody Gurski, Calvin B. Williams, Shaoyuan Wang, Bonnie N. Dittel, Qizhen Shi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system with no cure yet. Here, we report genetic engineering of hematopoietic stem cells (HSCs) to express myelin oligodendrocyte glycoprotein (MOG), specific
Externí odkaz:
https://doaj.org/article/ec6a2fddd5f34326a50e945eeb517ef7
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 719-730 (2021)
While platelet-specific gene therapy is effective in inducing immune tolerance to a targeted protein, how the reactivity of pre-existing immunity affects the efficacy, and whether CD8 T cells were involved in tolerization, is unclear. In this study,
Externí odkaz:
https://doaj.org/article/6b892202126248749c94d0de8a61d1a6
Autor:
Weiqing Jing, Juan Chen, Yuanhua Cai, Yingyu Chen, Jocelyn A. Schroeder, Bryon D. Johnson, Weiguo Cui, Qizhen Shi
Publikováno v:
Blood Advances, Vol 3, Iss 20, Pp 3099-3110 (2019)
Abstract: The development of neutralizing anti-FVIII antibodies (inhibitors) is a major complication of FVIII protein replacement therapy in patients with hemophilia A (HA). Although multiple lines of evidence indicate that the immune response agains
Externí odkaz:
https://doaj.org/article/538a91862d0c4f2abde43edc1239876f
Autor:
Chunyan Gao, Jocelyn A. Schroeder, Feng Xue, Weiqing Jing, Yuanhua Cai, Amelia Scheck, Saravanan Subramaniam, Sridhar Rao, Hartmut Weiler, Agnieszka Czechowicz, Qizhen Shi
Publikováno v:
Blood Advances, Vol 3, Iss 18, Pp 2700-2711 (2019)
Gene therapy offers the potential to cure hemophilia A (HA). We have shown that hematopoietic stem cell (HSC)–based platelet-specific factor VIII (FVIII) (2bF8) gene therapy can produce therapeutic protein and induce antigen-specific immune toleran
Externí odkaz:
https://doaj.org/article/83420e9f07c946c78fd2d34f6a0da735
Publikováno v:
Blood Advances, Vol 1, Iss 19, Pp 1565-1574 (2017)
Abstract: Immune tolerance induction (ITI) with aggressive infusion of factor VIII (FVIII) is the current strategy used to eradicate FVIII inhibitors and restore normal FVIII pharmacokinetics in inhibitor patients. Whether the use of FVIII products c
Externí odkaz:
https://doaj.org/article/8898e7ddcace42a88adb6d92c476cefb
Autor:
Dipica Haribhai, Xiaofeng Luo, Juan Chen, Shuang Jia, Linzheng Shi, Jocelyn A. Schroeder, Hartmut Weiler, Richard H. Aster, Martin J. Hessner, Jianda Hu, Calvin B. Williams, Qizhen Shi
Publikováno v:
Blood Advances, Vol 1, Iss 2, Pp 139-151 (2016)
Abstract: Platelets are a rich source of many cytokines and chemokines including transforming growth factor β 1 (TGF-β1). TGF-β1 is required to convert conventional CD4+ T (Tconv) cells into induced regulatory T (iTreg) cells that express the tran
Externí odkaz:
https://doaj.org/article/1c83410e71e3486a8582cf196bbae65d
Autor:
Xiaofeng Luo, Juan Chen, Jocelyn A. Schroeder, Kenneth P. Allen, Christina K. Baumgartner, Subramaniam Malarkannan, Jianda Hu, Calvin B. Williams, Qizhen Shi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Delivery of gene therapy as well as of biologic therapeutics is often hampered by the immune response of the subject receiving the therapy. We have reported that effective gene therapy for hemophilia utilizing platelets as a delivery vehicle engender
Externí odkaz:
https://doaj.org/article/516cae0516f04709af960b52562436a1
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:488-498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d847be60bb318b4e39c5dd17541ac7
https://doi.org/10.1016/j.jtha.2022.10.006
https://doi.org/10.1016/j.jtha.2022.10.006
Autor:
Hartmut Weiler, Juan Fang, Qizhen Shi, Robert R. Montgomery, David A. Wilcox, Jocelyn A. Schroeder, Erin A Kuether, Weiqing Jing
Publikováno v:
J Thromb Haemost
BACKGROUND: Rotational thromboelastometry (ROTEM) has been commonly used to assess the viscoelastic properties of the blood clotting process in the clinic for patients with a hemostatic or prothrombotic disorder. OBJECTIVE: To evaluate the capability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a4f2bb6666afac592f643dc292c337
https://doi.org/10.1111/jth.15456
https://doi.org/10.1111/jth.15456
Autor:
Yingyu Chen, Jocelyn A. Schroeder, Qizhen Shi, Yuanhua Cai, Paul E. Monahan, Juan Chen, Hongyin Yu, Jeremy G Mattson
Publikováno v:
Blood Adv
Gene therapy may lead to a cure for hemophilia B (HB) if it is successful. Data from clinical trials using adeno-associated virus (AAV)–mediated liver-targeted FIX gene therapy are very encouraging. However, this protocol can be applied only to adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec97330de4780f0e37766362007c4742
https://doi.org/10.1182/bloodadvances.2020004071
https://doi.org/10.1182/bloodadvances.2020004071