Výsledky vyhledávání - "Jocelyn P. Edathil"

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

Autor: David Loakes, Eric W. Barr, Daniel A. Harki, J. Martin Bollinger, Daniel M. Brown, Kathleen Too, Craig E. Cameron, Jessica E. Galarraga, Jocelyn P. Edathil, Blake R. Peterson, Jason D. Graci, Eric D. Smidansky

Publikováno v: Antimicrobial Agents and Chemotherapy. 52:971-979

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96ea8e8abb17deb5208112f429b061d
https://doi.org/10.1128/aac.01056-07

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ChemInform Abstract: One-Pot Synthesis of Nucleoside 5′-Triphosphates from Nucleoside 5′-H-Phosphonates

Autor: Runzhi Wu, Eric D. Smidansky, Craig E. Cameron, Blake R. Peterson, Jocelyn P. Edathil, Qi Sun

Publikováno v: ChemInform. 39

Nucleoside 5′-triphosphates (NTPs) play key roles in biology and medicine. However, these compounds are notoriously difficult to synthesize. We describe a one-pot method to prepare NTPs from nucleoside 5′-H-phosphonate monoesters via pyridinium p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7146e95dfdf5c8a0b996d8b8c66d28c7
https://doi.org/10.1002/chin.200830205

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Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

Autor: Daniel M. Brown, Craig E. Cameron, Blake R. Peterson, Jocelyn P. Edathil, Victoria S. Korneeva, David Loakes, Jason D. Graci, David Franco, Eric D. Smidansky, Kathleen Too, Aniko V. Paul, Daniel A. Harki

Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses. Here we sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c0d27eb01b61aff952e65a5247e57c
https://resolver.caltech.edu/CaltechAUTHORS:GRAjvi07