Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Autor: Seraina Blümli, Nicola Wiechens, Meng-Ying Wu, Vijender Singh, Marek Gierlinski, Gabriele Schweikert, Nick Gilbert, Catherine Naughton, Ramasubramanian Sundaramoorthy, Joby Varghese, Robert Gourlay, Renata Soares, David Clark, Tom Owen-Hughes

Publikováno v: Cell Reports, Vol 37, Iss 5, Pp 109943- (2021)

Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of

Externí odkaz: https://doaj.org/article/04921146582c4b71a0ec2443dd1ee13e

Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling. [version 1; peer review: 2 approved]

Autor: Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota

Publikováno v: Wellcome Open Research, Vol 4 (2019)

Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively. We have previously

Externí odkaz: https://doaj.org/article/825b99f7ce8c4131b3178e4180dfa8e2

Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal

Autor: Joby Varghese, Douglas Colby, Greg M. Findlay, Ian Chambers, Julia M. Richardson, Nicholas P. Mullin

Publikováno v: Febs Letters
Mullin, N P, Varghese, J, Colby, D, Richardson, J M, Findlay, G M & Chambers, I 2021, ' Phosphorylation of NANOG by CASEIN KINASE I regulates embryonic stem cell self-renewal ', FEBS Letters, vol. 595, no. 1, pp. 14-25 . https://doi.org/10.1002/1873-3468.13969

The self-renewal efficiency of mouse embryonic stem cells (ESCs) is determined by the concentration of the transcription factor NANOG. While NANOG binds thousands of sites in chromatin, the regulatory systems that control DNA binding are poorly chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbad1f3235d399af6bdba94bd314e54c
https://doi.org/10.1002/1873-3468.13969

Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H

Autor: Renata F. Soares, Gopal P. Sapkota, Ana Gázquez-Gutiérrez, Nicola T. Wood, Luke J. Fulcher, Theresa Tachie-Menson, Robert Gourlay, Joby Varghese, Thomas Macartney

Publikováno v: Cellular Signalling

The majority of mutations identified in patients with amelogenesis imperfecta have been mapped to FAM83H. As FAM83H expression is not limited to the enamel, how FAM83H contributes to amelogenesis is still largely unknown. We previously reported that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a3ce886c5dc6e8e666e7bdd12e63e6
https://pubmed.ncbi.nlm.nih.gov/32289446

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Autor: Nick Gilbert, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes, Renata F. Soares, Meng-Ying Wu, David J. Clark, Joby Varghese, Catherine Naughton, Marek Gierlinski, Gabriele Schweikert, Seraina Blümli, Nicola Wiechens, Robert Gourlay, Vijender Singh

Publikováno v: Cell Reports, Vol 37, Iss 5, Pp 109943-(2021)
Cell Reports

Summary The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c01009c6ac134ec37cd0b971e346a4
https://doi.org/10.1016/j.celrep.2021.109943