Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jobst Sievers"'
Autor:
Reinhard Dengler, Jobst Sievers, Lars-Ove Brandenburg, Günther Deuschl, Henrik Wilms, Thorsten Schwark, Ralph Lucius
Publikováno v:
Journal of Neuroscience Research. 88:16-23
Previous studies have shown that activin A, a neuroprotective cytokine and dimeric polypeptide composed of two betaA subunits, is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis. In this study, to elucidate further
Publikováno v:
Journal of Neuroimmunology. 212:106-111
Erythropoietin is a hematopoietic cytokine which is also produced in the brain under hypoxia. Since this pathology is associated with glial cell activation and release of cytotoxic molecules, we investigated the expression of EPO receptors (EPO-R) an
Publikováno v:
Brain Research. 1129:43-52
In the diseased central nervous system, astrogliosis is accompanied by microglial activation. Depending on the context of their activation, reactive astrocytes are involved in neuronal survival and regeneration in an either protective or impedimental
Publikováno v:
Journal of Neurochemistry. 101:718-728
Recent studies suggest that the formyl-peptide-receptor-like-1 (FPRL1) plays an essential role in inflammatory responses in the host defence mechanisms and neurodegenerative disorders. Furthermore, it may be involved in proinflammatory processes of p
This book is based on the NATO Advanced Research Workshop on'Mesenchymal-Epithelial Interactions in Neural Development'which was held in Berlin during March 1986. The idea that it may be the time for this workshop arose from a discussion among the or
Publikováno v:
Journal of Neuroimmunology. 144:139-142
Autopsy studies and animal experiments suggest that microglial inflammation contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS). Monocyte-chemoattractant protein (MCP-1) might play an important role in microglial recruitment. We st
Publikováno v:
Microscopy Research and Technique. 54:18-25
Microglia are the principal immune cells in the central nervous system (CNS), characterized by a highly specific morphology and unusual antigenic phenotype. An increasing number of studies have focused on the role of microglia in the pathogenesis of
Publikováno v:
Journal of Neuroimmunology. 98:89-95
We have previously shown that (i) the ramified phenotype and (ii) the microglia-specific pattern of membrane currents are induced not only in microglia, but also in monocytes and macrophages if they are cultured in the presence of astrocytes. These f
Publikováno v:
Journal of Neurocytology. 28:721-741
We have studied axon regeneration through the optic chiasm of adult rats 30 days after prechiasmatic intracranial optic nerve crush and serial intravitreal sciatic nerve grafting on day 0 and 14 post-lesion. The experiments comprised three groups of
Autor:
Thomas Unger, Jobst Sievers, Ralph Lucius, Thomas Herdegen, Philip Rosenstiel, Stefan Gallinat
Publikováno v:
The Journal of Experimental Medicine
The renin-angiotensin system (RAS) has been traditionally linked to blood pressure and volume regulation mediated through the angiotensin II (ANG II) type 1 (AT1) receptor. Here we report that ANG II via its ANG II type 2 (AT2) receptor promotes the