Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jobst, Röhmel"'
Autor:
Linus Piehler, Ralf Thalemann, Christine Lehmann, Stephanie Thee, Jobst Röhmel, Zulfiya Syunyaeva, Mirjam Stahl, Marcus A. Mall, Simon Y. Graeber
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The CFTR modulator drug elexacaftor/tezacaftor/ivacaftor (ETI) was shown to improve CFTR function and clinical symptoms in patients with cystic fibrosis (CF) with at least one F508del allele. Recently, some case reports suggested potent
Externí odkaz:
https://doaj.org/article/7ae8a967ccd34950a7f3cc31a5ca7a99
Autor:
Simon Y. Graeber, Anita Balázs, Niklas Ziegahn, Tihomir Rubil, Constanze Vitzthum, Linus Piehler, Marika Drescher, Kathrin Seidel, Alexander Rohrbach, Jobst Röhmel, Stephanie Thee, Julia Duerr, Marcus A. Mall, Mirjam Stahl
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12365 (2023)
CFTR modulator therapy with elexacaftor/tezacaftor/ivacaftor (ETI) has been approved for people with CF and at least one F508del allele in Europe. In the US, the ETI label has been expanded to 177 rare CFTR mutations responsive in Fischer rat thyroid
Externí odkaz:
https://doaj.org/article/d890a23b213e44b49515a4f60810d7b5
Autor:
Anita Balázs, Pamela Millar-Büchner, Michael Mülleder, Vadim Farztdinov, Lukasz Szyrwiel, Annalisa Addante, Aditi Kuppe, Tihomir Rubil, Marika Drescher, Kathrin Seidel, Sebastian Stricker, Roland Eils, Irina Lehmann, Birgit Sawitzki, Jobst Röhmel, Markus Ralser, Marcus A. Mall
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The nasal epithelium represents the first line of defense against inhaled pathogens, allergens, and irritants and plays a key role in the pathogenesis of a spectrum of acute and chronic airways diseases. Despite age-dependent clinical phenotypes trig
Externí odkaz:
https://doaj.org/article/fedeffcaad244444a146e43cd407fbae
Autor:
Mirjam Stahl, Cornelia Joachim, Ines Kirsch, Tatjana Uselmann, Yin Yu, Nadine Alfeis, Christiane Berger, Rebecca Minso, Isa Rudolf, Cornelia Stolpe, Xenia Bovermann, Lena Liboschik, Alena Steinmetz, Dunja Tennhardt, Friederike Dörfler, Jobst Röhmel, Klaudia Unorji-Frank, Claudia Rückes-Nilges, Bianca von Stoutz, Lutz Naehrlich, Matthias V. Kopp, Anna-Maria Dittrich, Olaf Sommerburg, Marcus A. Mall
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Background Multiple-breath washout (MBW)-derived lung clearance index (LCI) detects early cystic fibrosis (CF) lung disease. LCI was used as an end-point in single- and multicentre settings at highly experienced MBW centres in preschool children. How
Externí odkaz:
https://doaj.org/article/c6b3bc3e54c44d75a3a39aba2921ccab
Autor:
Simon Y. Graeber, Diane M. Renz, Mirjam Stahl, Sophia T. Pallenberg, Olaf Sommerburg, Lutz Naehrlich, Julian Berges, Martha Dohna, Felix C. Ringshausen, Felix Doellinger, Constanze Vitzthum, Jobst Röhmel, Christine Allomba, Susanne Hämmerling, Sandra Barth, Claudia Rückes-Nilges, Mark O. Wielpütz, Gesine Hansen, Jens Vogel-Claussen, Burkhard Tümmler, Marcus A. Mall, Anna-Maria Dittrich
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 206:311-320
Autor:
Vladimir G. Magalhães, Sören Lukassen, Maike Drechsler, Jennifer Loske, Sandy S. Burkart, Sandra Wüst, Eva-Maria Jacobsen, Jobst Röhmel, Marcus A. Mall, Klaus-Michael Debatin, Roland Eils, Stella Autenrieth, Aleš Janda, Irina Lehmann, Marco Binder
To cope with novel virus infections to which no prior adaptive immunity exists, the body strongly relies on the innate immune system. In such cases, including infections with SARS-CoV-2, children tend to fair better than adults. In the context of COV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c77e4fed6b9d3acc85255cc93877d01
https://doi.org/10.1101/2023.05.17.541103
https://doi.org/10.1101/2023.05.17.541103
Autor:
Sebastian Stricker, Niklas Ziegahn, Martin Karsten, Thomas Böckel, Heike Stich-Böckel, Jakob Maske, Evelyn Rugo, Anita Balázs, PamelaMillar Büchner, Chantip Dang-Heine, Mirjam Stahl, Roland Eils, Irina Lehmann, Leif E. Sander, Markus Ralser, Victor M. Corman, Marcus A. Mall, Birgit Sawitzki, Jobst Röhmel
Publikováno v:
Klinische Pädiatrie.
Autor:
Annalisa Addante, Mirjam Völler, Laura Schaupp, Kerstin Fentker, Markus Bardua, Aditi Kuppe, Julia Duerr, Linus Piehler, Jobst Röhmel, Stephanie Thee, Marieluise Kirchner, Matthias Ziehm, Daniel Lauster, Rainer Haag, Michael Gradzielski, Mirjam Stahl, Philipp Mertins, Sébastien Boutin, Simon Y. Graeber, Marcus A. Mall
Publikováno v:
Klinische Pädiatrie.
BackgroundWe recently demonstrated that the triple combination CFTR modulator therapy elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) improves lung ventilation and airway mucus plugging determined by multiple-breath washout and magnetic resonance imag
Autor:
Lucie, Loyal, Julian, Braun, Larissa, Henze, Beate, Kruse, Manuela, Dingeldey, Ulf, Reimer, Florian, Kern, Tatjana, Schwarz, Maike, Mangold, Clara, Unger, Friederike, Dörfler, Shirin, Kadler, Jennifer, Rosowski, Kübrah, Gürcan, Zehra, Uyar-Aydin, Marco, Frentsch, Florian, Kurth, Karsten, Schnatbaum, Maren, Eckey, Stefan, Hippenstiel, Andreas, Hocke, Marcel A, Müller, Birgit, Sawitzki, Stefan, Miltenyi, Friedemann, Paul, Marcus A, Mall, Holger, Wenschuh, Sebastian, Voigt, Christian, Drosten, Roland, Lauster, Nils, Lachman, Leif-Erik, Sander, Victor M, Corman, Jobst, Röhmel, Lil, Meyer-Arndt, Andreas, Thiel, Claudia, Giesecke-Thiel
Publikováno v:
Science (New York, N.Y.). 374(6564)
The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)–reactive and SARS-CoV-2–cross-reactive CD4
Autor:
Tatjana Schwarz, Sebastian Voigt, Jennifer Rosowski, Karsten Schnatbaum, Florian Kurth, Marcel A. Müller, Ulf Reimer, Marco Frentsch, Clara Unger, Jobst Röhmel, Maren Eckey, Florian Kern, Kübrah Gürcan, Marcus A. Mall, Nils Lachman, Birgit Sawitzki, Stefan Miltenyi, Maike Mangold, Lil Meyer-Arndt, Christian Drosten, Larissa Henze, Friedemann Paul, Zehra Uyar-Aydin, Friederike Dörfler, Beate Kruse, Shirin Kadler, LE Sander, Andreas Thiel, Holger Wenschuh, Andreas C. Hocke, Roland Lauster, Manuela Dingeldey, Claudia Giesecke-Thiel, Victor M. Corman, Lucie Loyal, Julian Braun, Stefan Hippenstiel
Publikováno v:
Science
The functional relevance of preexisting cross-immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a subject of intense debate. Here, we show that human endemic coronavirus (HCoV)-reactive and SARS-CoV-2-cross-reactive CD4+ T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3222812fcf1f743fc88043c274b35d1e