Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jobin K. Varughese"'
Autor:
Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje, Synnøve Nymark Aasen, Gro Vatne Røsland, Jobin K. Varughese, Marzieh Bahador, Simon Bernatz, Yannick Braun, Patrick N. Harter, Kai Ove Skaftnesmo, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Clifford G. Tepper, Kjell Petersen, Katherine W. Ferrara, Karl Johan Tronstad, Morten Lund-Johansen, Rudi Beschorner, Rolf Bjerkvig, Frits Thorsen
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across the blood-brain barri
Externí odkaz:
https://doaj.org/article/a1c9daff0c9545dea71bc7623876a310
Autor:
Jukka Westermarck, Jian Wang, Ning Yang, Tor-Christian Aase Johannessen, Gro V. Røsland, Anne Simonsen, Rolf Bjerkvig, Jobin K. Varughese, Amra Grudic, Abdul Latif, Bassam Janji, Oxana V. Denisova, Lars Prestegarden, Huaiyang Zhu, Karl Johan Tronstad, Terje Sundstrøm, Halala Saed, Mahdi Hasan-Olive, Morten Lund-Johansen, Anne Nordal
Publikováno v:
International Journal of Cancer.
Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14-15 months after surgery, radiation and chemotherapy using temozolomide (TMZ). A major problem is that the tumors acquire resistance to therapy. In an effort to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5283a5393a07184d853ca0c6cdf16c00
http://juuli.fi/Record/0333895218
http://juuli.fi/Record/0333895218
Autor:
Inderjit Daphu, Sindre Horn, Daniel Stieber, Jobin K. Varughese, Endy Spriet, Hege Avsnes Dale, Kai Ove Skaftnesmo, Rolf Bjerkvig, Frits Thorsen
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 15, Iss 5, Pp 8773-8794 (2014)
International Journal of Molecular Sciences, Vol 15, Iss 5, Pp 8773-8794 (2014)
Malignant melanoma is the most lethal form of skin cancer, with a high propensity to metastasize to the brain. More than 60% of melanomas have the BRAFV600E mutation, which activates the mitogen-activated protein kinase (MAPK) pathway [1]. In additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1f57efb7cf15dd3337e24421965a8fd4
http://europepmc.org/articles/PMC4057758
http://europepmc.org/articles/PMC4057758
Autor:
Aqeel Asghar Chaudhry, Roy Miodini Nilsen, Erling Myrseth, Jobin K. Varughese, Cathrine Nansdal Breivik, Paal Henning Pedersen, Morten Lund-Johansen
Publikováno v:
Neurosurgery. 73:48-57
There are few reports about the course of vestibular schwannoma (VS) patients following gamma knife radiosurgery (GKRS) compared with the course following conservative management (CM). In this study, we present prospectively collected data of 237 pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6badf10b541c8f4990a56c1b0c82255c
https://doi.org/10.1227/01.neu.0000429862.50018.b9
https://doi.org/10.1227/01.neu.0000429862.50018.b9
Publikováno v:
Journal of Neurosurgery. 116:706-712
Object Small vestibular schwannomas (VSs) are often conservatively managed and treated only upon growth. Growth is usually reported in mm/year, but describing the growth of a 3D structure by a single diameter has been questioned. As a result, VS grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b591edb562cba282215faa3a890528ef
https://doi.org/10.3171/2011.12.jns111662
https://doi.org/10.3171/2011.12.jns111662
Autor:
Sarah Tam, Kai Ove Skaftnesmo, Karl Johan Tronstad, Lars Prestegarden, Jobin K. Varughese, Kjell Petersen, Frits Thorsen, Clifford G. Tepper, Terje Sundstrøm, Morten Lund-Johansen, Gro V. Røsland, Francisco Azuaje, Elizabeth S. Ingham, Rolf Bjerkvig, Lisa Even, Katherine W. Ferrara
Despite major therapeutic advances in the management of patients with metastatic melanoma, brain metastases remain an intractable problem. It has proven difficult to identify and target single genes or pathways critical to brain metastasis formation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c167f8967385d896954b3c8e34f64b3
https://europepmc.org/articles/PMC4638636/
https://europepmc.org/articles/PMC4638636/
Autor:
Amra Grudic, Lars Prestegarden, Rolf Bjerkvig, Morten Lund-Johansen, Jobin K. Varughese, Tor-Christian Aase Johannessen, Halala Saed, Terje Sundstrøm
Glioblastomas are highly resistant to therapy and carries a dismal prognosis. Standard of care includes surgery followed by radiotherapy (RT) with concurrent and adjuvant chemotherapy with temozolomide (TMZ). The addition of TMZ to RT increases the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c3eb0ef774258d837bd576cab5df89
https://europepmc.org/articles/PMC4218027/
https://europepmc.org/articles/PMC4218027/
Autor:
Jobin K. Varughese, Cathrine Nansdal Breivik, Morten Lund-Johansen, Paal-Henning Pedersen, Roy Miodini Nilsen
Publikováno v:
Journal of Neurological Surgery Part B: Skull Base. 73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4516f2080ebdd7340685971543b0f31
https://doi.org/10.1055/s-0032-1314133
https://doi.org/10.1055/s-0032-1314133
Autor:
Jobin K. Varughese, Paal-Henning Pedersen, Morten Lund-Johansen, Ruby Mahesparan, Tore Wentzel-Larsen
Publikováno v:
International journal of radiation oncology, biology, physics. 84(2)
Purpose Gamma Knife radiosurgery (GKRS) has been increasingly used in the treatment of vestibular schwannoma (VS). Very few studies relate tumor control and post-treatment growth rates to pretreatment growth rates. Methods and Materials We prospectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d219f0cfe47887f246648359169dce
https://pubmed.ncbi.nlm.nih.gov/22682805
https://pubmed.ncbi.nlm.nih.gov/22682805
Autor:
Jobin K. Varughese, Flemming S. Vassbotn, Tore Wentzel-Larsen, Morten Lund-Johansen, Cathrine Nansdal Breivik
Publikováno v:
Neurosurgery. 70(5)
Background One hundred ninety-three patients with sporadic unilateral vestibular schwannoma given conservative management were enrolled in a prospective study. Objective To evaluate the efficacy of conservative management and to determine the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b06af860f0f5433fb4b9823bc6927d
https://pubmed.ncbi.nlm.nih.gov/22067416
https://pubmed.ncbi.nlm.nih.gov/22067416