Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Job de Lange"'
Autor:
Renaud L. M. Tissier, Janne J. M. van Schie, Rob M. F. Wolthuis, Job de Lange, Renée de Menezes
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background CRISPR screens provide large-scale assessment of cellular gene functions. Pooled libraries typically consist of several single guide RNAs (sgRNAs) per gene, for a large number of genes, which are transduced in such a way that ever
Externí odkaz:
https://doaj.org/article/aae7e52e22ba42efa7783aa38dc7a984
Publikováno v:
iScience, Vol 25, Iss 9, Pp 105012- (2022)
Summary: This study surveyed 669 plant scientists globally to elicit how (which outcomes of gene editing), where (which continent) and what (which crops) are most likely to benefit from CRISPR research and if there is a consensus about specific barri
Externí odkaz:
https://doaj.org/article/87a1cdb3d16f492d85ca5ab1266fb163
Autor:
Janne J. M. van Schie, Atiq Faramarz, Jesper A. Balk, Grant S. Stewart, Erika Cantelli, Anneke B. Oostra, Martin A. Rooimans, Joanna L. Parish, Cynthia de Almeida Estéves, Katja Dumic, Ingeborg Barisic, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mohammad Mahtab, Francesca M. Pisani, Hein te Riele, Najim Ameziane, Rob M. F. Wolthuis, Job de Lange
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Externí odkaz:
https://doaj.org/article/d1dd653aad8b4232927aa9fceeb46e31
Autor:
Atiq Faramarz, Jesper A Balk, Janne J M van Schie, Anneke B Oostra, Cherien A Ghandour, Martin A Rooimans, Rob M F Wolthuis, Job de Lange
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0220348 (2020)
In a process linked to DNA replication, duplicated chromosomes are entrapped in large, circular cohesin complexes and functional sister chromatid cohesion (SCC) is established by acetylation of the SMC3 cohesin subunit. Roberts Syndrome (RBS) and War
Externí odkaz:
https://doaj.org/article/70c181c7128843c4bada5b22ebd8f2ca
Autor:
Janne J. M. van Schie, Job de Lange
Publikováno v:
Cells, Vol 10, Iss 12, p 3455 (2021)
The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication. Replisome progression and establishme
Externí odkaz:
https://doaj.org/article/b3b6356a77934e049bd27f97c21c9994
Autor:
Janne JM van Schie, Klaas de Lint, Govind M Pai, Martin A Rooimans, Rob MF Wolthuis, Job de Lange
Publikováno v:
Life Science Alliance, 6(2). Rockefeller University Press
Life Science Alliance. Rockefeller University Press
van Schie, JJM, de Lint, K, Pai, MG, Rooimans, M A, Wolthuis, R & de Lange, J 2022, ' MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC ', Life Science Alliance .
van Schie, J J, de Lint, K, Pai, G M, Rooimans, M A, Wolthuis, R M & de Lange, J 2023, ' MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC ', Life Science Alliance, vol. 6, no. 2 . https://doi.org/10.26508/lsa.202201596
Life Science Alliance. Rockefeller University Press
van Schie, JJM, de Lint, K, Pai, MG, Rooimans, M A, Wolthuis, R & de Lange, J 2022, ' MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC ', Life Science Alliance .
van Schie, J J, de Lint, K, Pai, G M, Rooimans, M A, Wolthuis, R M & de Lange, J 2023, ' MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC ', Life Science Alliance, vol. 6, no. 2 . https://doi.org/10.26508/lsa.202201596
The leading strand–oriented alternative PCNA clamp loader DSCC1-RFC functions in DNA replication, repair, and sister chromatid cohesion (SCC), but how it facilitates these processes is incompletely understood. Here, we confirm that loss of human DS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d91388d155ba3fdf16774de19f72517
https://pure.amc.nl/en/publications/mms22ltonsl-functions-in-sister-chromatid-cohesion-in-a-pathway-parallel-to-dscc1rfc(e2ffed33-a8c6-4156-8eaf-7040997d00cb).html
https://pure.amc.nl/en/publications/mms22ltonsl-functions-in-sister-chromatid-cohesion-in-a-pathway-parallel-to-dscc1rfc(e2ffed33-a8c6-4156-8eaf-7040997d00cb).html
Autor:
Janne J.M. van Schie, Klaas de Lint, Thom M. Molenaar, Macarena Moronta Gines, Jesper A. Balk, Martin A. Rooimans, Khashayar Roohollahi, Govind M. Pai, Lauri Borghuis, Anisha R. Ramadhin, Josephine C. Dorsman, Kerstin S. Wendt, Rob M.F. Wolthuis, Job de Lange
The cohesin complex regulates higher order chromosome architecture through maintaining sister chromatid cohesion and folding chromatin by active DNA loop extrusion. Impaired cohesin function underlies a heterogeneous group of genetic syndromes and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c6e041a48df0e13e5f4d4f39f963111
https://doi.org/10.1101/2022.12.23.521474
https://doi.org/10.1101/2022.12.23.521474
Autor:
Renaud L. M. Tissier, Janne J. M. van Schie, Rob M. F. Wolthuis, Job de Lange, Renée de Menezes
Background CRISPR screens provide large-scale assessment of cellular gene functions. Pooled libraries typically consist of several single guide RNAs (sgRNAs) per gene, for a large number of genes, which are transduced in such a way that every cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb380cf14c7038264e35821d7029a80
https://doi.org/10.1101/2022.03.31.486584
https://doi.org/10.1101/2022.03.31.486584
Autor:
Sara, Carvalhal, Ingrid, Bader, Martin A, Rooimans, Anneke B, Oostra, Jesper A, Balk, René G, Feichtinger, Christine, Beichler, Michael R, Speicher, Johanna M, van Hagen, Quinten, Waisfisz, Mieke, van Haelst, Martijn, Bruijn, Alexandra, Tavares, Johannes A, Mayr, Rob M F, Wolthuis, Raquel A, Oliveira, Job, de Lange
Publikováno v:
Science Advances
Budding uninhibited by benzimidazoles (BUB1) contributes to multiple mitotic processes. Here, we describe the first two patients with biallelic BUB1 germline mutations, who both display microcephaly, intellectual disability, and several patient-speci
Autor:
Josephine C. Dorsman, Khashayar Roohollahi, Rob M. F. Wolthuis, Daphne E. C. Boer, Johannes C. Walter, Mats Ljungman, Román González-Prieto, Yuichiro Hara, Job de Lange, Tomoo Ogi, Alfred C.O. Vertegaal, Yuka Nakazawa, Yana van der Weegen, Ishwarya Venkata Narayanan, Tycho E. T. Mevissen, Klaas de Lint, Sylvie M. Noordermeer, Diana van den Heuvel, Marta San Martin Alonso, Martijn S. Luijsterburg, Annelotte P. Wondergem, Noud H. M. Klaassen, Janne J. M. van Schie
Publikováno v:
Nature Cell Biology, 23(6), 595-607. Nature Publishing Group
Nature Cell Biology
Nature Cell Biology, 23(6), 595-607. NATURE RESEARCH
van der Weegen, Y, de Lint, K, van den Heuvel, D, Nakazawa, Y, Mevissen, T E T, van Schie, J J M, San Martin Alonso, M, Boer, D E C, González-Prieto, R, Narayanan, I V, Klaassen, N H M, Wondergem, A P, Roohollahi, K, Dorsman, J C, Hara, Y, Vertegaal, A C O, de Lange, J, Walter, J C, Noordermeer, S M, Ljungman, M, Ogi, T, Wolthuis, R M F & Luijsterburg, M S 2021, ' ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation ', Nature Cell Biology, vol. 23, no. 6, pp. 595-607 . https://doi.org/10.1038/s41556-021-00688-9
Nature cell biology, 23(6), 595-607. Nature Publishing Group
Nat Cell Biol
Nature Cell Biology
Nature Cell Biology, 23(6), 595-607. NATURE RESEARCH
van der Weegen, Y, de Lint, K, van den Heuvel, D, Nakazawa, Y, Mevissen, T E T, van Schie, J J M, San Martin Alonso, M, Boer, D E C, González-Prieto, R, Narayanan, I V, Klaassen, N H M, Wondergem, A P, Roohollahi, K, Dorsman, J C, Hara, Y, Vertegaal, A C O, de Lange, J, Walter, J C, Noordermeer, S M, Ljungman, M, Ogi, T, Wolthuis, R M F & Luijsterburg, M S 2021, ' ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation ', Nature Cell Biology, vol. 23, no. 6, pp. 595-607 . https://doi.org/10.1038/s41556-021-00688-9
Nature cell biology, 23(6), 595-607. Nature Publishing Group
Nat Cell Biol
Two side-by-side papers report that the transcription elongation factor ELOF1 drives transcription-coupled repair and prevents replication stress.Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2732c1379e417cb3de9574f29cff90d4
https://doi.org/10.1038/s41556-021-00688-9
https://doi.org/10.1038/s41556-021-00688-9