SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma

Autor: Job J.M.H. van Bragt, Susanne Hansen, Ratko Djukanovic, Elisabeth H.D. Bel, Anneke ten Brinke, Scott S. Wagers, Anke H. Maitland-van der Zee, Celeste Porsbjerg

Publikováno v: ERJ Open Research, Vol 7, Iss 2 (2021)

Real-world evidence is important to help unravel unanswered problems in severe asthma and is valuable to better understand the patient experience and common clinical practice. The Severe Heterogeneous Asthma Registry, Patient-centred (SHARP) Clinical

Externí odkaz: https://doaj.org/article/26a34a22cbef4c7abcbbda697a53dd3d

The Influence of Smoking Status on Exhaled Breath Profiles in Asthma and COPD Patients

Autor: Stefania Principe, Job J.M.H. van Bragt, Cristina Longo, Rianne de Vries, Peter J. Sterk, Nicola Scichilone, Susanne J.H. Vijverberg, Anke H. Maitland-van der Zee

Publikováno v: Molecules, Vol 26, Iss 5, p 1357 (2021)

Breath analysis using eNose technology can be used to discriminate between asthma and COPD patients, but it remains unclear whether results are influenced by smoking status. We aim to study whether eNose can discriminate between ever- vs. never-smoke

Externí odkaz: https://doaj.org/article/f11d629bbae8486cb7212428363fe037

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

Autor: Job J.M.H. van Bragt, Michiel Alexander de Raaf, Harm Jan Bogaard, Pierre M Bet, Azar Kianzad, Merlijn Reijrink, Esther J. Nossent, Job R Schippers, Lucas R Celant, Lieuwe D. J. Bos, Jeroen N. Wessels, Mirte Muller, Chris Happé, Niels Pronk, Anton Vonk Noordegraaf, Leo M. A. Heunks, Liza Botros, E Marleen Kemper, Wim Boersma, Michel van den Heuvel, Hans P Grotjohan, Rianne J A Hoek, Carolina C Pamplona, Sara Azhang, Nicole P. Juffermans, Marry R Smit, Ivo van der Lee, Imke H Bartelink, Bas F M van Raaij, Janneke E Stalenhoef, Wouter Hoefsloot, Pieter R. Tuinman, Ariana Lammers, Katrien Eger, Boaz D Hazes, E Laurien van der Lee, Karin A T Boomars, Arthur L E M Vanhove, Frances S. de Man, Laura A Hagens, Anke-Hilse Maitland-van der Zee, Elisabeth C W Neefjes, Marcus J. Schultz, Pearl F M Mau Asam, Erik Duijvelaar, Patrick J Smeele, A. Josien Smits, Frank W J M Smeenk, Elise M A Slob, Laurien M A Oswald, Ary Serpa Neto, J. J. Miranda Geelhoed, Jessie Van Wezenbeek, Gert-Jan Braunstahl, Herman M A Hofstee, Romke Hoekstra, Peter I. Bonta, Jurjan Aman, Nienke Paternotte, Renate Kos, Ahmed A. Bayoumy, Peter W A Kunst, Maria J Overbeek, Adinda Mieras, Yurika L E van Glabbeek

Publikováno v: lancet. Respiratory medicine, 9(9), 957-968. Elsevier Limited
The Lancet Respiratory Medicine, 9(9), 957-968. ELSEVIER SCI LTD
The Lancet Respiratory Medicine, 9(9), 957-968. Elsevier Ltd.
Lancet Respiratory Medicine, 9, 957-968
Aman, J, Duijvelaar, E, Botros, L, Kianzad, A, Schippers, J R, Smeele, P J, Azhang, S, Bartelink, I H, Bayoumy, A A, Bet, P M, Boersma, W, Bonta, P I, Boomars, K A T, Bos, L D J, van Bragt, J J M H, Braunstahl, G-J, Celant, L R, Eger, K A B, Geelhoed, J J M, van Glabbeek, Y L E, Grotjohan, H P, Hagens, L A, Happe, C M, Hazes, B D, Heunks, L M A, van den Heuvel, M, Hoefsloot, W, Hoek, R J A, Hoekstra, R, Hofstee, H M A, Juffermans, N P, Kemper, E M, Kos, R, Kunst, P W A, Lammers, A, van der Lee, I, van der Lee, E L, Maitland-van der Zee, A-H, Mau Asam, P F M, Mieras, A, Muller, M, Neefjes, L, Nossent, E J, Oswald, L M A, Overbeek, M J, Pamplona, C, Paternotte, N, Pronk, N, de Raaf, M A, van Raaij, B F M, Reijrink, M, Schultz, M J, Serpa Neto, A, Slob, E M, Smeenk, F W J M, Smit, M R, Smits, A J, Stalenhoef, J E, Tuinman, P R, Vanhove, A L E M, Wessels, J N, van Wezenbeek, J C C, Vonk Noordegraaf, A, de Man, F S & Bogaard, H J 2021, ' Imatinib in patients with severe COVID-19 : a randomised, double-blind, placebo-controlled, clinical trial ', Lancet respiratory medicine, vol. 9, no. 9, pp. 957-968 . https://doi.org/10.1016/S2213-2600(21)00237-X
The Lancet. Respiratory Medicine
Lancet respiratory medicine, 9(9), 957-968. Elsevier Limited
Lancet Respiratory Medicine, 9, 9, pp. 957-968
The Lancet Respiratory Medicine

Background The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental and early clinical data suggest that the tyrosine-kinase inhibitor imatinib reverses pulmonary capillary leak. Metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b9388602de3565960dbc68949c8a0a
https://pure.amc.nl/en/publications/imatinib-in-patients-with-severe-covid19(40a385b0-de53-45cd-aff2-cb6b5cdfc6d3).html

The influence of smoking status on exhaled breath profiles in asthma and COPD patients

Autor: Peter J. Sterk, Cristina Longo, Job J.M.H. van Bragt, Anke H. Maitland-van der Zee, Nicola Scichilone, Rianne de Vries, Susanne J. H. Vijverberg, Stefania Principe

Publikováno v: Molecules, Vol 26, Iss 1357, p 1357 (2021)
Molecules, 26(5):1357. Multidisciplinary Digital Publishing Institute
Molecules
Volume 26
Issue 5

Breath analysis using eNose technology can be used to discriminate between asthma and COPD patients, but it remains unclear whether results are influenced by smoking status. We aim to study whether eNose can discriminate between ever- vs. never-smoke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4030d1b6fabf0e21b7eddaecda93df
http://hdl.handle.net/10447/550163

Identification of recent exacerbations in COPD patients by electronic nose

Autor: Eric G. Haarman, Annelies Lucas, Paul Brinkman, Job J.M.H. van Bragt, Els J.M. Weersink, Sigrid Kester, Elisabeth H. Bel, Frans H.C. de Jongh, Johannes C C M In 't Veen, Rianne de Vries, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, Peter J. Sterk

Publikováno v: van Bragt, J J M H, Brinkman, P, de Vries, R, Vijverberg, S J H, Weersink, E J M, Haarman, E G, de Jongh, F H C, Kester, S, Lucas, A, In 't Veen, J C C M, Sterk, P J, Bel, E H D & Maitland-van der Zee, A H 2020, ' Identification of recent exacerbations in COPD patients by electronic nose ', BMJ Open, vol. 6, no. 4, 00307 . https://doi.org/10.1183/23120541.00307-2020
ERJ Open Research
article-version (VoR) Version of Record
ERJ open research, 6(4):00307-2020. European Respiratory Society
ERJ Open Research, 6(4):00307-2020. European Respiratory Society
BMJ Open, 6(4):00307. BMJ Publishing Group
ERJ Open Research, Vol 6, Iss 4 (2020)

Molecular profiling of exhaled breath by electronic nose (eNose) might be suitable as a noninvasive tool that can help in monitoring of clinically unstable COPD patients. However, supporting data are still lacking. Therefore, as a first step, this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498401115e206bd74e7ea12fe49170f2
https://doi.org/10.1183/23120541.00307-2020