Výsledky vyhledávání - "Joash Dominic Joy"

Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer

Autor: Joash Dominic Joy, Beatrice Malacrida, Florian Laforêts, Panoraia Kotantaki, Eleni Maniati, Sarah Hopkins, Ianire Garrobo-Calleja, Julien Gautrot, Frances Balkwill

Publikováno v: Cancer Research. 83:4576-4576

Chimeric antigen receptor (CAR)-T cell therapies have promising outcomes in hematologic malignancies but limited activity in solid tumors. We used 3-dimentional (3D) in vitro human cell models of increasing complexity to investigate resistance to CAR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db78278d2e21066e5dc5edf4d43b1ca8
https://doi.org/10.1158/1538-7445.am2023-4576

Zobrazit plný text záznamu

Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer

Autor: Joash Dominic Joy, Beatrice Malacrida, Florian Laforêts, Panoraia Kotantaki, Eleni Maniati, Sarah Hopkins, Ianire Calleja, Sara Brett, Takis Athanasopoulos, Sadfer Ali, Peter Emery-Billcliff, Ida Ricciardelli, Charlotte Kay, Jayne Colebrook, Magda Ali, Katherine Strong, Frances Balkwill

Publikováno v: Cancer Research. 82:693-693

We have assessed the utility of 3-dimensional (3D) in vitro human cell models to understand barriers to chimeric antigen receptor (CAR)-T cell activity in high-grade serous ovarian cancer, (HGSOC) a disease with a poor response to immunotherapy. We d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbffdf97742f1aeb6f944c5f2178f4a5
https://doi.org/10.1158/1538-7445.am2022-693

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání