Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma

Autor: Raquel Palao-Suay, Ricardo Sanz-Fernández, Antonio Ferruelo-Alonso, Blanca Vázquez-Lasa, Carolina Sánchez-Rodríguez, María Rosa Aguilar, Luis Rojo Del Olmo, Joaquin Yanes-Diaz, Juan Riestra-Ayora

Publikováno v: Pharmaceutics
Volume 13
Issue 8
Pharmaceutics, Vol 13, Iss 1242, p 1242 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Currently, new treatments are required to supplement the current standard of care for head and neck squamous cell carcinoma (HNSCC). The phosphatidylinositol3-kinase (PI3K) signaling pathway is commonly altered and activated in HNSCC. PHT-427 is a du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffa18acd52fad396f620914afd3ce29

Paclitaxel-loaded polymeric nanoparticles based on a-tocopheryl succinate for the treatment of head and neck squamous cell carcinoma: in vivo murine model

Autor: Joaquin Yanes-Diaz, Raquel Palao-Suay, Juan Riestra-Ayora, Carolina Sánchez-Rodríguez, Ana Martín-Hita, María Rosa Aguilar, Ricardo Sanz-Fernández

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Drug Delivery
article-version (VoR) Version of Record
Digital.CSIC. Repositorio Institucional del CSIC
instname
Drug Delivery, Vol 28, Iss 1, Pp 1376-1388 (2021)

The prognosis of patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) is generally poor. New treatments are required to supplement the current standard of care. Paclitaxel (PTX), an effective chemotherapeutic for HNSCC, ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8118d240325e2585cf657d69bf52812e
http://hdl.handle.net/11268/10228

Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers

Autor: Joaquin Yanes-Diaz, Alba Larran-Jimenez, Cristina Vaduva, Juan Riestra-Ayora, Eduardo Martin-Sanz, Jonathan Esteban-Sanchez, Cristina Molina-Quiros

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
European Archives of Oto-Rhino-Laryngology

Purpose The study aimed to determine the incidence and long-term evolution of COVID-related olfactory (OD) and gustatory (GD) dysfunction, the recovery timeline, and the association with other symptoms. The secondary objective was to identify the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1817ab1e4301b0538d385ab6ba5b2d25
http://hdl.handle.net/11268/11554

Vibration-induced nystagmus and Head Impulse Test screening for vestibular schwannoma. Our experience of 56 cases

Autor: Eduardo Martin-Sanz, Jonathan Esteban, Angela Cuesta, Angel Batuecas-Caletrio, Joaquin Yanes-Diaz, Alba Larran

KEY POINTS1.Our population represents a common clinical scenario in which auditory profiles do not determine eligibility for further evaluation.2.Mean VOR gain in the VS group, was significantly lower on the affected side in the three canal planes.3.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f4a5125ffd6e6b2796c184f9fe1851e
https://doi.org/10.22541/au.158880253.38727917

Delayed Effect and Gain Restoration After Intratympanic Gentamicin for Menière's Disease

Autor: Eduardo Martin-Sanz, Jonathan Esteban-Sanchez, Joaquin Yanes Diaz, Nicolas Perez-Fernandez, Ricardo Sanz-Fernández

Publikováno v: Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 40(1)

This study aimed to evaluate the changes in the VOR gain after intratympanic gentamicin therapy and to correlate them with the mid-term effects on the control of vertigo, in a population of Menière's disease patients.The study design was a prospecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4726f3fc20c78160cc663ab3271890ef
https://pubmed.ncbi.nlm.nih.gov/30334870