Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Joaquin Rullas-Trincado"'
Autor:
María Martínez-Hoyos, Esther Perez-Herran, Gulcin Gulten, Lourdes Encinas, Daniel Álvarez-Gómez, Emilio Alvarez, Santiago Ferrer-Bazaga, Adolfo García-Pérez, Fátima Ortega, Iñigo Angulo-Barturen, Joaquin Rullas-Trincado, Delia Blanco Ruano, Pedro Torres, Pablo Castañeda, Sophie Huss, Raquel Fernández Menéndez, Silvia González del Valle, Lluis Ballell, David Barros, Sundip Modha, Neeraj Dhar, François Signorino-Gelo, John D. McKinney, Jose Francisco García-Bustos, Jose Luis Lavandera, James C. Sacchettini, M. Soledad Jimenez, Nuria Martín-Casabona, Julia Castro-Pichel, Alfonso Mendoza-Losana
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 291-301 (2016)
Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage o
Externí odkaz:
https://doaj.org/article/24f2b3c2204144699909714a57e27a13
Autor:
Eric L. Nuermberger, Maria Santos Martínez-Martínez, Olalla Sanz, Beatriz Urones, Jorge Esquivias, Heena Soni, Rokeya Tasneen, Sandeep Tyagi, Si-Yang Li, Paul J. Converse, Helena I. Boshoff, Gregory T. Robertson, Gurdyal S. Besra, Katherine A. Abrahams, Anna M. Upton, Khisimuzi Mdluli, Gary W. Boyle, Sam Turner, Nader Fotouhi, Nicholas C. Cammack, Juan Miguel Siles, Marta Alonso, Jaime Escribano, Joel Lelievre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H. Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, Elena Jiménez
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis -infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0efb69d85ba133e740da0ce522724b
https://doi.org/10.1128/aac.00132-22
https://doi.org/10.1128/aac.00132-22
Autor:
Matt Davies, Simon Cozens, Morris Muliaditan, Adeep Puri, Andrew Skingsley, Alison Gaudion, David Tenero, Alfonso Mendoza-Losana, John Tonkyn, Joaquin Rullas-Trincado, Alex Carlton, Stephanie Gresham, Geo Derimanov, David Barros-Aguirre
Publikováno v:
Antimicrobial Agents and Chemotherapy
This first-time-in-human (FTIH) study evaluated the safety, tolerability, pharmacokinetics, and food effect of single and repeat oral doses of GSK3036656, a leucyl-tRNA synthetase inhibitor. In part A, GSK3036656 single doses of 5 mg (fed and fasted)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfbc11cd17d99730c0a1ebcfc8d9bc7
https://doi.org/10.1128/aac.00240-19
https://doi.org/10.1128/aac.00240-19
Autor:
Eamonn Gormley, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Eva Maria Lopez-Roman, Nacho Aguilo, Ana Maria Toledo, Carlos Martin, Iñigo Angulo-Barturen
Publikováno v:
Clinical and Vaccine Immunology
Clinical and Vaccine Immunology; Vol 21
Clinical and Vaccine Immunology; Vol 21
Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcb00f34cffbb1a5558a9727c5af187