Zobrazeno 1 - 10
of 458
pro vyhledávání: '"Joaquin N"'
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 9306-9315 (2023)
The complement system is part of the innate immune system and has been shown to be altered in autism spectrum disorder (ASD). Fragile-X syndrome (FXS) is the main genetic cause of ASD and studies suggest a dysregulation in the immune system in patien
Externí odkaz:
https://doaj.org/article/802551c21b9c4ef9935e7090b09bf23c
Autor:
Katherine J. Blandin, David A. Narvaiz, Donald Gregory Sullens, Paige D. Womble, Samantha L. Hodges, Matthew S. Binder, Amanda Faust, Phuoc H. Nguyen, Zachary J. Pranske, Joaquin N. Lugo
Publikováno v:
Brain Sciences, Vol 14, Iss 9, p 892 (2024)
Background: Fragile X Syndrome (FXS) is the leading monogenetic cause of autism spectrum disorder (ASD) and is associated with seizures. We examined the impact of repeated seizures on the behavioral and molecular changes in male Fmr1 knockout (KO) mi
Externí odkaz:
https://doaj.org/article/cc04b26b61464eaabac1c6f8124df7da
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 609-622 (2023)
Abstract Objective Epilepsy can be comorbid with cognitive impairments. Recent evidence suggests the possibility that cognitive decline in epilepsy may be associated with mechanisms typical of Alzheimer's disease (AD). Neuropathological hallmarks of
Externí odkaz:
https://doaj.org/article/65726055432d4a489eb4e4ded3cbf96e
Autor:
Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Adult neurogenesis is a persistent phenomenon in mammals that occurs in select brain structures in both healthy and diseased brains. The tumor suppressor gene, phosphatase and tensin homolog deleted on chromosome 10 (Pten) has previously been found t
Externí odkaz:
https://doaj.org/article/84e29741d7154636b33a8b26651c12f0
Autor:
Katherine M. Keever, Ying Li, Paige D. Womble, D. Gregory Sullens, Gonzalo H. Otazu, Joaquin N. Lugo, Raddy L. Ramos
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Brain malformations cause cognitive disability and seizures in both human and animal models. Highly laminated structures such as the neocortex and cerebellum are vulnerable to malformation, affecting lamination and neuronal connectivity as well as ca
Externí odkaz:
https://doaj.org/article/ee9845c9da47494e87b7010c21ed6a1c
Autor:
Danielle Santana‐Coelho, Samantha L. Hodges, Saul I. Quintero, Paige D. Womble, D. Greg Sullens, David A. Narvaiz, Rebecca Herrera, Melanie J. Sekeres, Joaquin N. Lugo
Publikováno v:
Brain and Behavior, Vol 13, Iss 8, Pp n/a-n/a (2023)
Abstract Objectives Fragile X syndrome is the main monogenetic cause of intellectual disability and autism. Alterations in the immune system are commonly found in these developmental disorders. We and others have demonstrated that Fmr1 mutant mice pr
Externí odkaz:
https://doaj.org/article/a7050befed384236a611bb5243684464
Publikováno v:
Brain Disorders, Vol 8, Iss , Pp 100055- (2022)
Mouse communicative behaviors are referred to as ultrasonic vocalizations (USVs). USVs are relevant to human health and are commonly recorded with the Avisoft-SASLab Pro recording system and the DeepSqueak system however, no study has compared DeepSq
Externí odkaz:
https://doaj.org/article/58306fe03e4644a5b2b79bc15c471096
Autor:
Suzanne O Nolan, Samantha L Hodges, Matthew S Binder, Gregory D Smith, James T Okoh, Taylor S Jefferson, Brianna Escobar, Joaquin N Lugo
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262916 (2022)
The current study aimed to further address important questions regarding the therapeutic efficacy of omega-3 fatty acids for various behavioral and neuroimmune aspects of the Fmr1 phenotype. To address these questions, our experimental design utilize
Externí odkaz:
https://doaj.org/article/820e9c2234be40e4a849a85b25441efb
Autor:
Suzanne O. Nolan, Joaquin N. Lugo
Publikováno v:
F1000Research, Vol 7 (2018)
Background: Loss of FMR1 is associated with Fragile X syndrome, amongst the most prevalent inherited intellectual disability. Despite extensive research in this area, previous studies have failed to detect consistent evidence of cognitive impairments
Externí odkaz:
https://doaj.org/article/86c3c39041154d36aa96625f49a65ac6
Autor:
Conner D. Reynolds, Taylor S. Jefferson, Meagan Volquardsen, Ashvini Pandian, Gregory D. Smith, Andrew J. Holley, Joaquin N. Lugo
Publikováno v:
F1000Research, Vol 6 (2018)
Background: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. Previous studies report the drug to be effective in both human and non-human models with pre-exis
Externí odkaz:
https://doaj.org/article/c7d654673719496a9adf10ebd4c2c662