Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

Autor: Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C. T. Mok, Ho Ko

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)

Li, Chen, Vong, Zhao et al. show that glucagon-like peptide-1 receptor agonist reverses transcriptomic aging signatures in mouse glial and neurovascular cells. This study suggests that glucagon-like peptide-1 receptor agonists may be considered as a

Externí odkaz: https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c8

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

Autor: Lei Zhao, Zhongqi Li, Joaquim S. L. Vong, Xinyi Chen, Hei-Ming Lai, Leo Y. C. Yan, Junzhe Huang, Samuel K. H. Sy, Xiaoyu Tian, Yu Huang, Ho Yin Edwin Chan, Hon-Cheong So, Wai-Lung Ng, Yamei Tang, Wei-Jye Lin, Vincent C. T. Mok, Ho Ko

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Blood–brain barrier dysfunction occurs in ageing and in neurodegenerative diseases. Here, the authors use scRNA-seq to identify transcriptomic changes in endothelial cell subtypes in the aged mouse brain, some of which may generalize to human and c

Externí odkaz: https://doaj.org/article/0cd6b88e4d0b4038b2b9807cac7e8608

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

Autor: Lei Zhao, Xinyi Chen, Ho Ko, Joaquim S. L. Vong, Yun Kwok Wing, Junzhe Huang, Vincent Mok, Zhongqi Li, Bonaventure Ip, Leo Y. C. Yan, Hei-Ming Lai

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-6 (2021)
Communications Biology

Pharmacological reversal of brain aging is a long-sought yet challenging strategy for the prevention and treatment of age-related neurodegeneration, due to the diverse cell types and complex cellular pathways impacted by the aging process. Here, we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca8396ea1965a9b468ab96057e62976
https://doaj.org/article/b6e03838a0f54cd39260f2154383d3c8

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET

Autor: Stefan Günther, Thomas Braun, Yanhan Jia, Julio Cordero, Ludger Fink, Thomas Boettger, Rajkumar Savai, Boyan K. Garvalov, Werner Seeger, Anshu Singh, Alina Asafova, Luca Caputo, Gergana Dobreva, Till Acker, Guillermo Barreto, Joaquim S. L. Vong

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2019, 216 (6), pp.1377-1395. ⟨10.1084/jem.20181394⟩

Jia et al. demonstrate that lamin B1 acts as a tumor suppressor in lung cancer. Lamin B1 loss promotes lung cancer development and metastasis by loss of PRC2 recruitment to chromatin and activation of the RET/p38 signaling axis.
Although abnorma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fbb3deae67cdb59fea3b4810d4460b
http://europepmc.org/articles/PMC6547854

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonism

Autor: Lei Zhao, Hei-Ming Lai, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Joaquim S. L. Vong, Junzhe Huang, Vincent Mok, Ho Ko, Zhongqi Li, Xinyi Chen

Pharmacological reversal of brain aging is a long-sought yet challenging strategy for the prevention and treatment of age-related neurodegeneration, due to the diverse cell types and complex cellular pathways impacted by the aging process. Here, we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcdf9e9211b731bed60e5cc8023404cd
https://doi.org/10.1101/2020.12.21.423879