Detection of senescence using machine learning algorithms based on nuclear features

Autor: Imanol Duran, Joaquim Pombo, Bin Sun, Suchira Gallage, Hiromi Kudo, Domhnall McHugh, Laura Bousset, Jose Efren Barragan Avila, Roberta Forlano, Pinelopi Manousou, Mathias Heikenwalder, Dominic J. Withers, Santiago Vernia, Robert D. Goldin, Jesús Gil

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Cellular senescence is a stress response with broad pathophysiological implications. Senotherapies can induce senescence to treat cancer or eliminate senescent cells to ameliorate ageing and age-related pathologies. However, the success of s

Externí odkaz: https://doaj.org/article/5c897b7121a9453294556dca1837ca68

Non-alcoholic fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms.

Autor: Rebeca Carter, Angelina Mouralidarane, Junpei Soeda, Shuvra Ray, Joaquim Pombo, Ruma Saraswati, Marco Novelli, Giuseppe Fusai, Francesca Rappa, Chiara Saracino, Valerio Pazienza, Lucilla Poston, Paul D Taylor, Manlio Vinciguerra, Jude A Oben

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e89505 (2014)

Emerging evidence suggests that maternal obesity (MO) predisposes offspring to obesity and the recently described non-alcoholic fatty pancreas disease (NAFPD) but involved mechanisms remain unclear. Using a pathophysiologically relevant murine model,

Externí odkaz: https://doaj.org/article/62ffbba5fa094c259117c4d364798a9d

Bioluminescence imaging ofCyp1a1-luciferase reporter mice demonstrates prolonged activation of the aryl hydrocarbon receptor in the lung

Autor: Nicolas Veland, Hannah J Gleneadie, Karen E Brown, Alessandro Sardini, Joaquim Pombo, Andrew Dimond, Vanessa Burns, Karen Sarkisyan, Chris Schiering, Zoe Webster, Matthias Merkenschlager, Amanda G Fisher

Aryl hydrocarbon receptor (AHR) signalling integrates biological processes that sense and respond to environmental, dietary, and metabolic challenges to ensure tissue homeostasis. AHR is a transcription factor that is inactive in the cytosol but upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcf2488338b59db0f87baf56a465a216
https://doi.org/10.1101/2023.05.30.542862

Wave‐influenced deposition of carbonate‐rich sediment on the insular shelf of Santa Maria Island, Azores

Autor: Zhongwei Zhao, Neil C. Mitchell, Rui Quartau, Sandra Moreira, Liliana Rusu, Carlos S. Melo, Sérgio P. Ávila, Diya Das, Pedro Afonso, Joaquim Pombo, João Duarte, Aurora Rodrigues

Publikováno v: Mitchell, N, Quartau, R, Moreira, S, Beier, C, Zhao, Z, Ávila, S & Rodrigues, A 2022, ' Wave-influenced deposition of carbonate-rich sediment on the insular shelf of Santa Maria Island, Azores ', Sedimentology, vol. 69, no. 4, pp. 1547-1572 . https://doi.org/10.1111/sed.12963

Formulae for sediment thresholds of motion are commonly based on flume experiments on rounded quartz particles and it is unclear how well they predict thresholds in natural settings. Here, sediment threshold shear stresses were calculated from one su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a1249881fc434f3a11652183512ded
https://doi.org/10.1111/sed.12963

Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity

Autor: Paul D. Taylor, Catherine Williamson, Georgia Papacleovoulou, Afshan N. Malik, Joaquim Pombo, Xanthi Maragkoudaki, David C. Rees, Anja Czajka, Emilie Stolarczyk, Jane K. Howard, Shadi Abu-Hayyeh, Lucilla Poston, Matthew Naylor

Publikováno v: Maragkoudaki, X, Naylor, M, Papacleovoulou, G, Stolarczyk, E, Rees, D, Pombo, J M, Abu-Hayyeh, S, Czajka, A, Howard, J K, Malik, A N, Williamson, C, Poston, L & Taylor, P D 2020, ' Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity ', International Journal of Obesity, vol. 44, no. 12, pp. 2382-2393 . https://doi.org/10.1038/s41366-020-00682-5

Objectives: We hypothesised that maternal diet-induced-obesity has adverse consequences for offspring energy expenditure and susceptibility to obesity in adulthood, and that the prebiotic polydextrose (PDX) would prevent the consequences of programmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a6a155b368d522c62f07199e969b8a
https://doi.org/10.1038/s41366-020-00682-5