Zobrazeno 1 - 10
of 916
pro vyhledávání: '"Joaquim M S, Cabral"'
Autor:
Sofia P. Agostinho, Mariana A. Branco, Diogo E. S. Nogueira, Maria Margarida Diogo, Joaquim M. S. Cabral, Ana L. N. Fred, Carlos A. V. Rodrigues
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The main objective of the present work was to highlight differences and similarities in gene expression patterns between different pluripotent stem cell cardiac differentiation protocols, using a workflow based on unsupervised machine learni
Externí odkaz:
https://doaj.org/article/640f5d5a2b2943afa7777f2120f816d5
Autor:
Mariana A. Branco, Tiago P. Dias, Joaquim M. S. Cabral, Perpetua Pinto-do-Ó, Maria Margarida Diogo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Stem cell models of organogenesis are a valuable tool for the study of human development, but often lack the context of tissue-tissue interaction. Here they generate human multi-lineage organoids comprising pro-epicardium, septum transversum, and liv
Externí odkaz:
https://doaj.org/article/29a61448f082416197324931e820c993
Publikováno v:
Science and Technology of Advanced Materials, Vol 22, Iss 1, Pp 461-480 (2021)
The growing prevalence of vascular diseases worldwide has emphasized the need for novel tissue-engineered options concerning the development of vascularized 3D constructs. This study reports, for the first time, the use of external magnetic fields to
Externí odkaz:
https://doaj.org/article/c962126d98504b778b944c7e10a8d631
Autor:
Teresa Franchi-Mendes, Marília Silva, Ana Luísa Cartaxo, Ana Fernandes-Platzgummer, Joaquim M. S. Cabral, Cláudia L. da Silva
Publikováno v:
Bioengineering, Vol 10, Iss 9, p 1067 (2023)
Tissue engineering approaches within the muscle context represent a promising emerging field to address the current therapeutic challenges related with multiple pathological conditions affecting the muscle compartments, either skeletal muscle or smoo
Externí odkaz:
https://doaj.org/article/e104123014a049d0a8e7dda152d606c4
Autor:
Sara Bucar, André Dargen de Matos Branco, Márcia F. Mata, João Coutinho Milhano, Íris Caramalho, Joaquim M. S. Cabral, Ana Fernandes-Platzgummer, Cláudia L. da Silva
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Umbilical cord blood (UCB) is a clinically relevant alternative source of hematopoietic stem/progenitor cells (HSPC). To overcome the low cell number per UCB unit, ex vivo expansion of UCB HSPC in co-culture with mesenchymal strom
Externí odkaz:
https://doaj.org/article/f5f4c140897c48e9ac47d4ee5677c0ca
Autor:
Laura Alves, Vanessa Machado, João Botelho, José João Mendes, Joaquim M. S. Cabral, Cláudia L. da Silva, Marta S. Carvalho
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1352 (2023)
Cell-based therapies using periodontal ligament stromal cells (PDLSC) for periodontal regeneration may represent an alternative source for mesenchymal stromal cells (MSC) to MSC derived from bone marrow (MSC(M)) and adipose tissue (MSC(AT)). We aimed
Externí odkaz:
https://doaj.org/article/fcd070e0a9b645a28f5c535c7178c4c6
Autor:
Cláudia C. Miranda, Michael L. Akenhead, Teresa P. Silva, Michael A. Derr, Mohan C. Vemuri, Joaquim M. S. Cabral, Tiago G. Fernandes
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The demand for large cell numbers for cellular therapies and drug screening applications requires the development of scalable platforms capable of generating high-quality populations of tissue-specific cells derived from human pluripotent stem cells
Externí odkaz:
https://doaj.org/article/0c8462da4f5942b4b3226a9f9783e060
Autor:
Tiago P. Dias, Tânia Baltazar, Sandra N. Pinto, Tiago G. Fernandes, Fábio Fernandes, Maria Margarida Diogo, Manuel Prieto, Joaquim M. S. Cabral
Publikováno v:
Stem Cells International, Vol 2022 (2022)
Human induced pluripotent stem cells (hiPSCs) can be efficiently differentiated into cardiomyocytes (CMs), which can be used for cardiac disease modeling, for drug screening, and to regenerate damaged myocardium. Implementation of xeno-free culture s
Externí odkaz:
https://doaj.org/article/c31a15afdda44fe7931ffbd28461ef0f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mesenchymal stromal cells (MSC) have been proposed as an emerging cell-based therapeutic option for regenerative medicine applications as these cells can promote tissue and organ repair. In particular, MSC have been applied for the treatment of bone
Externí odkaz:
https://doaj.org/article/d52bc28e1d6747cea37a9acf5b0e8d52
Autor:
William O. S. Salvador, Inês A. B. Ribeiro, Diogo E. S. Nogueira, Frederico C. Ferreira, Joaquim M. S. Cabral, Carlos A. V. Rodrigues
Publikováno v:
Bioengineering, Vol 9, Iss 12, p 791 (2022)
Over recent years, the field of cell and gene therapy has witnessed rapid growth due to the demonstrated benefits of using living cells as therapeutic agents in a broad range of clinical studies and trials. Bioprocess economic models (BEMs) are funda
Externí odkaz:
https://doaj.org/article/f5cafa8a4cae44f48137f24f2fddcc75