Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Joaquim Grego-Bessa"'
Autor:
Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Joaquim Grego-Bessa, Alice Cheng, Katherine A Rauen, Anatoly Urisman, Frank McCormick, Gerardo Jimenez, Pau Castel
Publikováno v:
eLife, Vol 11 (2022)
RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds, ubiquitinates, and p
Externí odkaz:
https://doaj.org/article/186607128fba49338544764486aeac28
Autor:
Jasmine C. Wong, Pedro A. Perez-Mancera, Tannie Q. Huang, Jangkyung Kim, Joaquim Grego-Bessa, Maria del pilar Alzamora, Scott C. Kogan, Amnon Sharir, Susan H. Keefe, Carolina E. Morales, Denny Schanze, Pau Castel, Kentaro Hirose, Guo N. Huang, Martin Zenker, Dean Sheppard, Ophir D. Klein, David A. Tuveson, Benjamin S. Braun, Kevin Shannon
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
Somatic KRAS mutations are highly prevalent in many cancers. In addition, a distinct spectrum of germline KRAS mutations causes developmental disorders called RASopathies. The mutant proteins encoded by these germline KRAS mutations are less biochemi
Externí odkaz:
https://doaj.org/article/3d9175f56bd4469b9994c659c5e9bbbc
Autor:
Stanislao Igor Travisano, Vera Lucia Oliveira, Belén Prados, Joaquim Grego-Bessa, Rebeca Piñeiro-Sabarís, Vanesa Bou, Manuel J Gómez, Fátima Sánchez-Cabo, Donal MacGrogan, José Luis de la Pompa
Publikováno v:
eLife, Vol 8 (2019)
Coronaries are essential for myocardial growth and heart function. Notch is crucial for mouse embryonic angiogenesis, but its role in coronary development remains uncertain. We show Jag1, Dll4 and activated Notch1 receptor expression in sinus venosus
Externí odkaz:
https://doaj.org/article/e068dc4aa318465da0fa0ae32f43e0ae
Autor:
Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Gaetano D'Amato, Luis J Jiménez-Borreguero, José Luis de la Pompa
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0203100 (2018)
During vertebrate cardiac development NOTCH signaling activity in the endocardium is essential for the crosstalk between endocardium and myocardium that initiates ventricular trabeculation and valve primordium formation. This crosstalk leads later to
Externí odkaz:
https://doaj.org/article/ec82dc3876b8451197920a6a45b2c0ed
Autor:
Nathan J. VanDusen, Jose Casanovas, Joshua W. Vincentz, Beth A. Firulli, Marco Osterwalder, Javier Lopez-Rios, Rolf Zeller, Bin Zhou, Joaquim Grego-Bessa, José Luis De La Pompa, Weinian Shou, Anthony B. Firulli
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2071-2083 (2014)
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during cardiac morphogenesis via expression and function within myocardial, neural crest, and epicardial cell populations. Here, we show that Hand2 plays two essential
Externí odkaz:
https://doaj.org/article/5eb81b79e4424059b0feed6fcefa3da6
Autor:
Joaquim Grego-Bessa, Joshua Bloomekatz, Pau Castel, Tatiana Omelchenko, José Baselga, Kathryn V Anderson
Publikováno v:
eLife, Vol 5 (2016)
Epithelial morphogenesis and stability are essential for normal development and organ homeostasis. The mouse neural plate is a cuboidal epithelium that remodels into a columnar pseudostratified epithelium over the course of 24 hr. Here we show that t
Externí odkaz:
https://doaj.org/article/203d2187bb2e4224a3b2fcdbed3e66b4
Autor:
Joaquim Grego-Bessa, Paula Gómez-Apiñaniz, Belén Prados, Manuel José Gómez, Donal MacGrogan, José Luis de la Pompa
BACKGROUNDCardiac ventricles are essential for providing the contractile force of the beating heart throughout life. How the primitive endocardium-layered myocardial projections called trabeculae form and mature into the adult ventricles is of great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea4b346939bd917d40d559e686d815f
https://doi.org/10.1101/2022.11.28.518154
https://doi.org/10.1101/2022.11.28.518154
Autor:
Marcos Siguero-Álvarez, Alejandro Salguero-Jiménez, Joaquim Grego-Bessa, Jorge de la Barrera, Donal MacGrogan, Belén Prados, Fernando Sánchez-Sáez, Rebeca Piñeiro-Sabarís, Natalia Felipe-Medina, Carlos Torroja, Manuel José Gómez, María Sabater-Molina, Rubén Escribá, Ivonne Richaud-Patin, Olalla Iglesias-García, Mauro Sbroggio, Sergio Callejas, Declan P. O’Regan, Kathryn A. McGurk, Ana Dopazo, Giovanna Giovinazzo, Borja Ibañez, Lorenzo Monserrat, José María Pérez-Pomares, Fátima Sánchez-Cabo, Alberto M. Pendas, Angel Raya, Juan R. Gimeno-Blanes, José Luis de la Pompa
The complex genetics underlying human cardiac disease is evidenced by its heterogenous manifestation, multigenic basis, and sporadic occurrence. These features have hampered disease modeling and mechanistic understanding. Here, we show that 2 structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c9d5c2f3da4e9446d77a979ec3f9f2
http://hdl.handle.net/2445/193600
http://hdl.handle.net/2445/193600
Publikováno v:
Journal of visualized experiments : JoVE. (185)
The study of the cellular and molecular mechanisms underlying the development of the mammalian heart is essential to address human congenital heart disease. The development of the primitive cardiac valves involves the epithelial-to-mesenchymal transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ad71e6ac060626604d55b86d6b51567
https://pubmed.ncbi.nlm.nih.gov/35969077
https://pubmed.ncbi.nlm.nih.gov/35969077
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39889358249b8530ccc3dee31c6704c7
https://doi.org/10.3791/64207-v
https://doi.org/10.3791/64207-v