Výsledky vyhledávání - "Joaquim Duran-Vilaregut"

Characterization of Amyloid-β Granules in the Hippocampus of SAMP8 Mice

Autor: Jaume del Valle, Antoni Camins, Jordi Vilaplana, Gemma Manich, Mercè Pallàs, Clara Mercader, Carme Pelegrí, Joaquim Duran-Vilaregut

Publikováno v: Journal of Alzheimer's Disease. 25:535-546

The senescence accelerated mouse-prone 8 (SAMP8) strain of mice is an experimental model of accelerated senescence that has also been proposed as a model of Alzheimer's disease as it shares several features with this dementia. We have recently report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78221db15d9ba27d58ca47b5a752e0c5
https://doi.org/10.3233/jad-2011-101713

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Cerebral Amyloid Angiopathy, Blood-Brain Barrier Disruption and Amyloid Accumulation in SAMP8 Mice

Autor: Joaquim Duran-Vilaregut, Gemma Manich, Jordi Vilaplana, Antoni Camins, Mercè Pallàs, Carme Pelegrí, Jaume del Valle

Publikováno v: Neurodegenerative Diseases. 8:421-429

Cerebrovascular dysfunction and β-amyloid peptide deposition on the walls of cerebral blood vessels might be an early event in the development of Alzheimer’s disease. Here we studied the time course of amyloid deposition in blood vessels and blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dd1c9dfea2883a2f64193537f9d586
https://doi.org/10.1159/000324757

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Blood-brain barrier disruption in the striatum of rats treated with 3-nitropropionic acid

Autor: Joaquim Duran-Vilaregut, Jordi Vilaplana, Antoni Camins, Mercè Pallàs, Jaume del Valle, Carme Pelegrí

Publikováno v: NeuroToxicology. 30:136-143

3-Nitropropionic acid (3-NPA) is a natural toxin that is used to induce models of Huntington's disease (HD) in experimental animals. Here we injected 3-NPA into Sprague–Dawley rats in order to evaluate its effects on the blood-brain barrier (BBB).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae806763e128270a58ccac30ba5881de
https://doi.org/10.1016/j.neuro.2008.10.007

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Study of the transcytosis of an anti-transferrin receptor antibody with a Fab' cargo across the blood-brain barrier in mice

Autor: Jordi Vilaplana, Mercè Pallàs, Carme Pelegrí, Joaquim Duran-Vilaregut, Gemma Manich, Itsaso Cabezón, Antoni Camins, Jaume del Valle

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 49(4)

One strategy used to transport pharmacologically active substances across the blood-brain barrier (BBB) is to link the substance to a molecule capable of crossing the BBB using a receptor-mediated transcellular transport system in brain capillary end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8396f49eb2e5da1d24168e1db071877f
https://pubmed.ncbi.nlm.nih.gov/23748097

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Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3β in the striatum of rats treated with 3-nitropropionic acid

Autor: Jordi Vilaplana, Joaquim Duran-Vilaregut, Gemma Manich, Jaume del Valle, Antoni Camins, Mercè Pallàs, Carme Pelegrí

Publikováno v: Journal of neuroscience research. 90(9)

3-Nitropropionic acid (3-NPA) is a mitochondrial toxin used in the laboratory to replicate neurodegenerative conditions that are accompanied by degeneration of the caudate-putamen. 3-NPA induces depletion in ATP production, reactive oxygen species pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614175e9263ffb2f5651382c7a18a8d8
https://pubmed.ncbi.nlm.nih.gov/22505033

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Neuronal apoptosis in the striatum of rats treated with 3-nitropropionic acid is not triggered by cell-cycle re-entry

Autor: Jaume del Valle, Joaquim Duran-Vilaregut, Gemma Manich, Antoni Camins, Jordi Vilaplana, Carme Pelegrí, Mercè Pallàs

Publikováno v: Neurotoxicology. 32(6)

Although terminally differentiated neurons lack the capacity to undergo cell division, they retain the capacity to reactivate the cell cycle. This reactivation, however, has been linked to the degeneration of neurons in many experimental models of ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b5bec99763877a7e5038b29786ad93
https://pubmed.ncbi.nlm.nih.gov/21827787

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Early amyloid accumulation in the hippocampus of SAMP8 mice

Autor: Mark A. Smith, Joaquim Duran-Vilaregut, Jordi Vilaplana, Carme Pelegrí, Antoni Camins, Jaume del Valle, Gemma Casadesus, Gemma Manich, Mercè Pallàs

Publikováno v: Journal of Alzheimer's disease : JAD. 19(4)

Late-onset Alzheimer's disease (AD) is the most common form of AD appearing after 65 years of age. To date, however, there are no non-genetically manipulated rodent models that develop a similar sporadic onset of AD with age-related amyloid-beta (Abe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d653ad375cb7f9ebcf9b1a4492a21ffa
https://pubmed.ncbi.nlm.nih.gov/20061609

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Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes

Autor: Jordi Vilaplana, Jaume del Valle, Carme Pelegrí, Felix Junyent, Antoni Camins, Gemma Manich, Mercè Pallàs, Joaquim Duran-Vilaregut

Publikováno v: Neurochemistry international. 56(3)

The intraperitoneal administration of 3-nitropropionic acid, which is commonly used to induce toxicity models of Huntington's disease in experimental animals, produces severe brain injury in the lateral part of the striatum. We studied the presence o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e5d440092e7ceb912ba749ad87ac8f
https://pubmed.ncbi.nlm.nih.gov/19969037

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Time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice

Autor: Gemma Manich, Carme Pelegrí, Jordi Vilaplana, Jaume del Valle, Antoni Camins, Mercè Pallàs, Joaquim Duran-Vilaregut

Publikováno v: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 27(1)

Senescence of the cerebrovascular system and an abnormal function of the blood-brain barrier have been related with Alzheimer's disease. We studied here the time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1032c776eb94c58759a45ff350b4a08b
https://pubmed.ncbi.nlm.nih.gov/18992318

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