β-Amyloid-induced activation of Caspase-3 in primary cultures of rat neurons

Autor: Marta Llansola, Nuria Marín, Francisco Bosch-Morell, Belén Romero, Francisco J. Romero, Vicente Felipo, Joaquín Romá

Publikováno v: Mechanisms of Ageing and Development. 119:63-67

It is known that beta-amyloid peptide (Abeta) contributes to the neurodegeneration in Alzheimer's disease (AD) and operates through activation of an apoptotic pathway. Apoptotic signal is driven by a family of cysteine proteases called caspases. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c4532ba7023a51cd770a9c92b11d49
https://doi.org/10.1016/s0047-6374(00)00172-x

Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve

Autor: Francisco J. Puertas, Carlos Hermenegildo, Joaquín Romá, Juan Segura-Aguilar, Elena Monsalve, Eberhard Nies, Francisco J. Romero, Victoria Higueras

Publikováno v: Neurochemical Research. 16:157-161

Nervous tissue, central and peripheral, is, as any other, subject to variations in oxygen tension, and to the attack of different xenobiotics; these situations may promote the generation of activated oxygen species of free radical character. Results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639b147a8a6a6dfa36fefb24e2b04c74
https://doi.org/10.1007/bf00965704

Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment

Autor: Francisco Bosch-Morell, Jorge M. Barcia, María Miranda, Samuel Asensio, Joaquín Romá, Francisco J. Romero, Pilar Monfort, Siv Johnsen-Soriano, Vicente Felipo

Publikováno v: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

Background: Most of the previously published data suggest a role for oxidative or nitrosative stress in ethanol-induced nervous system damage. Moreover, ethanol is able to impair learning abilities in adult mammalian brain, a process suggested to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523acb4f6abecf83cf9078b8d128fa70
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3115

Interferon decreases serum lipid peroxidation products of hepatitis C patients

Autor: Angel Raya, Joaquín Romá, Miguel A. Serra, J M Rodrigo, Francisco J. Romero, Victoria Higueras

Publikováno v: Free Radical Biology and Medicine. 16:131-133

Thiobarbituric acid reactive substances (TBARS) concentration in serum has been determined in healthy subjects and in patients suffering acute hepatitis and chronic cases of hepatitis C. Treatment with interferon of the chronic active hepatitis C pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d912e70c4e1af3754436d2a9ae4aba5
https://doi.org/10.1016/0891-5849(94)90250-x

Efficacy of the antioxidant ebselen in experimental uveitis

Autor: Francisco J. Puertas, Manuel Díaz-Llopis, Francisco Bosch-Morell, Nuria Marín, Joaquín Romá, Francisco J. Romero

Publikováno v: Free radical biologymedicine. 27(3-4)

Inflammation results in the production of free radicals. In a model of experimental uveitis upon subcutaneous injection of endotoxin to Lewis rats, i.e., endotoxin-induced experimental uveitis (EIU), we have evaluated the status of the antioxidant ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25083d93875e53ab245701b8436125aa
https://pubmed.ncbi.nlm.nih.gov/10468213