Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joaquín Amat"'
Autor:
Bruna Calsina, Richard P. Beckmann, Raquel Torres-Guzmán, Maria Jose Lallena, Joaquín Amat, Alfonso De Dios, Beatriz Alvarez, Ann M. McNulty, Ana Hermoso, Karsten Boehnke, Sean Buchanan, Jian Du, Xueqian Gong, Carmen Baquero
Publikováno v:
Oncotarget
Abemaciclib is an ATP-competitive, reversible kinase inhibitor selective for CDK4 and CDK6 that has shown antitumor activity as a single agent in hormone receptor positive (HR+) metastatic breast cancer in clinical trials. Here, we examined the mecha
Autor:
Martin Lange, Johannes Haybaeck, Sandra Liebs, Joaquín Amat, Christian R. A. Regenbrecht, Juan A. Velasco, Maria Jose Lallena, Dirk Schumacher, Reinhold Schäfer, Christoph Reinhard, Rubén Haro, Karsten Boehnke, Philip W. Iversen
Publikováno v:
Slas Discovery
The application of patient-derived three-dimensional culture systems as disease-specific drug sensitivity models has enormous potential to connect compound screening and clinical trials. However, the implementation of complex cell-based assay systems
Autor:
Philip W. Iversen, Cecilia Mur, Karsten Boehnke, Carmen Baquero, Severine I. Gharbi, Carlos Marugán, Xueqian Gong, Alfonso deDios, Sandra Gomez, Richard Beckman, Sean Buchanan, Maria Jose Lallena, Raquel Torres-Guzmán, Joaquín Amat
Publikováno v:
Cancer Research. 77:LB-318
Lung cancer is the most common tumor cancer worldwide and approximately 15-25% of the patients with lung adenocarcinoma have KRAS driven tumors. These malignancies involve, in the majority of cases, a constitutive activation of KRAS signaling pathway
Autor:
Joaquín Amat Royo
Publikováno v:
Revista Icade. Revista de las Facultades de Derecho y Ciencias Económicas y Empresariales. :221
The recent addition of China’s market economy less than 20 years ago, has already become the world’s biggest exporter. Its special appeal in costs and potential market have led it to become the first recipient of international foreign investment.
Autor:
Ana Hermoso, Bruna Calsina, Sean Buchanan, Cecilia Mur, Xueqian Gong, Karsten Boehnke, Carmen Baquero, Joaquín Amat, Richard P. Beckmann, Alfonso De Dios, Raquel Torres, Maria Jose Lallena
Publikováno v:
Cancer Research. 76:2836-2836
Breast cancer is the second most common cancer worldwide after lung cancer. About 70% of breast cancers express estrogen receptor α (ER+) and/or progesterone receptor (PR+), and these biomarkers are indicative of hormone dependence. However up to 50
Autor:
Karsten Boehnke, Juan A. Velasco, Philip W. Iversen, Joaquín Amat, Christoph Reinhard, Bruna Calsina, Sean Buchanan, Christian R. A. Regenbrecht, Ana Hermoso, Raquel Torres, Marie-Laure Yaspo, Richard P. Beckmann, Dirk Schumacher, Hans Lehrach, Alfonso De Dios, Maria Jose Lallena
Publikováno v:
Cancer Research. 76:2829-2829
Proper patient-tailoring strategy and the validation of novel therapeutic targets remain enormous challenges during drug discovery processes. Patient-derived three-dimensional organoid cell culture models possess great potential to associate compound
Abstract 3101: In-vitro characterization of Abemaciclib pharmacology in ER+ breast cancer cell lines
Autor:
Ann M. McNulty, Bruna Calsina, Raquel Torres, Sean Buchanan, Xueqian Gong, Joaquín Amat, Richard P. Beckmann, Maria Jose Lallena, Jian Du, Karsten Boehnke, Ana Hermoso, Alfonso De Dios
Publikováno v:
Cancer Research. 75:3101-3101
Dysregulation of the cell-cycle is a hallmark of cancer and genetic alterations in its regulatory machinery (or checkpoints) occur in most human tumors. The majority these defects are found in genes encoding for proteins regulating G1 phase progressi
Autor:
Royo, Joaquín Amat
Publikováno v:
MK - Marketing más Ventas; Jul2012, Vol. 26 Issue 281, p20-28, 9p