Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice

Autor: Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria de Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sá, João Paulo Capela, Félix Carvalho, Vera Marisa Costa

Publikováno v: Heliyon, Vol 10, Iss 11, Pp e31608- (2024)

Doxorubicin (DOX) is an anthracycline used to treat a wide range of tumours. Despite its effectiveness, it is associated with a long range of adverse effects, of which cognitive deficits stand out. The present study aimed to assess the neurologic adv

Externí odkaz: https://doaj.org/article/6f95bfc09f1245b5980cbd637fdda73e

List of contributors

Autor: Giorgia Adani, Evgenios Agathokleous, Athina-Maria Aloizou, Arturo Anadon, Michael Antoniou, Irma Ares, Michael Aschner, Katerina Aslanoglou, Daiana Silva Avila, Nausicaa Berselli, J. Biosca-Brull, Dimitrios P. Bogdanos, Michael B. Briggs, Edward J. Calabrese, Daniela Calina, Joao Paulo Capela, Helena Carmo, Felix Carvalho, N. Chandrasekaran, M.T. Colomina, Carolina Constantin, Emanuela Corsini, Chiara Costa, Vera Marisa Costa, Efthimios Dardiotis, Carlos Augusto Fernandes de Oliveira, Flavia Suelen de Oliveira Pereira, Pasquale Del Gaudio, Tianqi Deng, Ana Rita Dias Carvalho, Aleksandra Buha Djordjevic, Anca Oana Docea, Nikolaos Drakoulis, Konstantinos Farsalinos, Concettina Fenga, Tommaso Filippini, Andreas D. Flouris, Persefoni Fragkiadaki, Domniki Fragou, Larissa Tuanny Franco, Jingqi Fu, Valentina Galbiati, Carlos A. Garcia-Gonzalez, Spyridoula Georgaki, Briguglio Giusi, Giorgos Gkikas, Kirill Golokhvast, Telma M. Gomes, Marina Goumenou, L. Guardia-Escote, Jiabin Guo, Thomas Hartung, Antonio F. Hernandez, Ekhtear Hossain, Leonidas G. Ioannou, Helena Kandarova, Spyros P. Karakitsios, Vasiliki Karzi, George E. Kochiadakis, Ronald N. Kostoff, Leda Kovatsi, Christopher L. Kuhlman, Christina Kyriakos, Ioanna Lagou, Lawrence H. Lash, Ioannis Liampas, John C. Lipscomb, Shengnan Liu, Ambra Maddalon, Rui F. Malheiro, Konstantinos Mantzios, Denisa Margina, Maria-Aranzazu Martinez, Marta Martinez, Maria-Rosa Martinez-Larranaga, Robin Mesnage, Panayiotis D. Mitsias, M. Morales, Khurram Muaz, Amitava Mukherjee, Monica Neagu, Katerina Nikitara, Dragana Nikitovic, Taxiarchis Konstantinos Nikolouzakis, George Mihai Nitulescu, Georgiana Nitulescu, Octavian Tudorel Olaru, Akinobu Ota, Eren Ozcagli, Maria Papasavva, Georgia Pateraki, C. Perez-Fernandez, Jingbo Pi, Konstantin Pikula, Alan L. Porter, Carmen Purdel, Weidong Qu, Thiagarajan Raman, Elisavet Renieri, Ramin Rezaee, F. Sanchez-Santed, Evangelia Sarandi, Dimosthenis A. Sarigiannis, Kasturi Sarkar, R. Seenivasan, Parames C. Sil, Joao P. Silva, Vasileios Siokas, Marcell Valandro Soares, Paul M. Stemmer, Vignesh Thiagarajan, Konstantinos Tsarouhas, Aristidis M. Tsatsakis, Ioannis Tsatsakis, Christina Tsitsimpikou, Dimitris Tsoukalas, Lydia Tsoutsoubi, Anca Ungurianu, Elena Vakonaki, Alexander Vardavas, Constantine Vardavas, Loukia Vassilopoulou, Aristidis S. Veskoukis, Marco Vinceti, Marc Vives Enrich, Zacharenia Vlata, Md Wahiduzzaman, Heather M. Wallace, Huihui Wang, Yuanyuan Xu, Qiang Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a0c65fe4020d16de83485a2d4a72aec
https://doi.org/10.1016/b978-0-323-85215-9.00058-1

Study of the potential toxicity of adrenaline to neurons, using the SH-SY5Y human cellular model

Autor: Vera Marisa Costa, João Paulo Capela, Maria Lourdes Bastos, Fernando Remião, Kurt James Varner, José Alberto Duarte, Félix Carvalho

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 59 (2023)

Abstract Prolonged overexposure to catecholamines causes toxicity, usually credited to continuous adrenoceptor stimulation, autoxidation, and the formation of reactive pro-oxidant species. Non-differentiated SH-SY5Y cells were used to study the possi

Externí odkaz: https://doaj.org/article/2e16d9635d4a4183998547ec2c62e21c

Mitoxantrone-induced neurotoxicity in CD-1 mice

Autor: Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Eduarda Fernandes, Susana Isabel Sá, João Paulo Capela, Félix Carvalho, Vera Marisa Costa

Publikováno v: RevSALUS, Vol 4, Iss Sup (2022)

Externí odkaz: https://doaj.org/article/b21bc7e2daa74f769f51e417dd9f164d

Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells

Autor: João Barbosa Martins, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Capela

Publikováno v: Journal of Toxicology, Vol 2013 (2013)

Paraquat (PQ), a cationic nonselective bipyridyl herbicide, has been used as neurotoxicant to modulate Parkinson’s disease in laboratory settings. Other compounds like rotenone (ROT), a pesticide, and 1-methyl-4-phenylpyridinium ion (MPP+) have bee

Externí odkaz: https://doaj.org/article/b77c30ab9eb8427682b5a380bcd84e77