Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Joao Passos"'
Autor:
Rachael Redgrave, Emily Dookun, Laura Booth, Omowumi Folaranm, Simon Tual-Chalot, Jason Gill, Andrew Owens, Ioakim Spyridopoulos, Joao Passos, Gavin Richardson
Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now standard therapy, pathological remodeling leading to heart failure remains a clinical problem. Cellular senescence has been shown to contribute to disease p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58fca09f64e6cb356227a20cecdf7e68
https://doi.org/10.21203/rs.3.rs-2776501/v1
https://doi.org/10.21203/rs.3.rs-2776501/v1
Autor:
Joao Passos, James Chapman, Hanna Salmonowicz, Stella Victorelli, Helene Martini, Joel Riley, Catherine Cloix, Gerald Shadel, Jair Machado Espindola Netto, Diana Jurk, Anthony Lagnado, Lilian Gomez, Joshua Farr, Dominik Saul, Becca Reed, Laura Greaves, Derek Mann, Claudio Akio Masuda, Sundeep Khosla, Haiming Dai, Nathan LeBrasseur, Viktor Korolchuk, Xue Shae, Peter Adams, Stephen Tait, Maria Grazia Vizioli, Alva Sainz Castillo, Scott Kaufmann, Zhixun Dou
Senescent cells drive age-related tissue dysfunction partially via the induction of a chronic senescence-associated secretory phenotype (SASP). Mitochondria are major regulators of the SASP; however, the underlying mechanisms have not been elucidated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9bb90e82b7dfd7efa8a95281ed4df58
https://doi.org/10.21203/rs.3.rs-1247316/v1
https://doi.org/10.21203/rs.3.rs-1247316/v1
A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues
Autor:
Sundeep Khosla, Dominik Saul, Robyn Laura Kosinsky, Elizabeth Atkinson, Madison Doolittle, Xu Zhang, Nathan LeBrasseur, Robert Pignolo, Paul Robbins, Laura Niedernhofer, Yuji Ikeno, Diana Jurk, Joao Passos, LaTonya Hickson, Ailing Xue, David Monroe, Tamara Tchkonia, James Kirkland, Joshua Farr
Although cellular senescence is increasingly recognized as driving multiple age-related co-morbidities through the senescence-associated secretory phenotype (SASP), in vivo senescent cell identification, particularly in bulk or single cell RNA-sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1296585d5a708f31d2b20be66deb3d70
https://doi.org/10.21203/rs.3.rs-1034608/v1
https://doi.org/10.21203/rs.3.rs-1034608/v1
Publikováno v:
Innovation in Aging. 6:196-196
Skeletal muscle aging is marked by the loss and atrophy of resident fibers, and the accumulation of functionally diverse cell types including fibroblasts, adipocytes, and immune cells. Senescent cells amass in multiple tissues with advancing age wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d51f8aa52510513e5d083f2d058e2db
https://doi.org/10.1093/geroni/igac059.785
https://doi.org/10.1093/geroni/igac059.785
Publikováno v:
Nat Cell Biol
Nature Cell Biology
Nature Cell Biology
Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b502f7910d56ac6f4beedaf001a0080
https://pubmed.ncbi.nlm.nih.gov/35165420
https://pubmed.ncbi.nlm.nih.gov/35165420
Autor:
Diana Jurk, Joao Passos
Publikováno v:
Mechanisms of Ageing and Development. 202:111631
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530aefecad51432c57174c121fabb214
https://doi.org/10.1016/j.mad.2022.111631
https://doi.org/10.1016/j.mad.2022.111631
Autor:
João de Azevedo, José Joaquim da Silva Pereira Caldas
Publikováno v:
Biblioteca Nacional de Portugal.
Externí odkaz:
http://www.manuscriptorium.com/apps/index.php?direct=record&pid=BNDPL_-BNDPL_MSS_143_N_692TMUHK9-pt
Publikováno v:
Free Radical Research. 40:1277-1283
Oxygen free radicals have a major impact on senescence of primary human cells. In replicative senescence, which is induced by uncapping of telomeres, the rate of telomere shortening is largely determined by telomere-specific accumulation of DNA damag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b8cad29d41a90ef28fd49f3c9767dd
https://doi.org/10.1080/10715760600917151
https://doi.org/10.1080/10715760600917151
Autor:
Wissler Gerdes, Erin O., Misra, Avanish, Netto, Jair Machado Espindola, Tchkonia, Tamar, Kirkland, James L. *
Publikováno v:
In Mechanisms of Ageing and Development December 2021 200