Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joao Nuno Moreira"'
Autor:
Davide Cangelosi, Chiara Brignole, Veronica Bensa, Roberto Tamma, Fabiana Malaguti, Barbara Carlini, Elena Giusto, Enzo Calarco, Patrizia Perri, Domenico Ribatti, Nuno André Fonseca, Joao Nuno Moreira, Alessandra Eva, Loredana Amoroso, Massimo Conte, Alberto Garaventa, Angela Rita Sementa, Maria Valeria Corrias, Mirco Ponzoni, Fabio Pastorino
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104300- (2022)
Summary: Background: Neuroblastoma (NB) represents the most frequent form of extra-cranial solid tumour of infants, responsible for 15% of childhood cancer deaths. Nucleolin (NCL) prognostic value in NB was investigated. Methods: NCL protein expressi
Externí odkaz:
https://doaj.org/article/7c7feb7bb2a447eba44682ff9676b2fb
This book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, ch
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1700 (2023)
Among the different types of nanosystems that have been investigated for therapeutic use, lipid-based ones are the most explored, as they have advantages over non-lipid nanosystems, especially for improving the transport and efficacy of drugs through
Externí odkaz:
https://doaj.org/article/84a453ac2c044289af747a606ddad5e1
Autor:
Jacinta O. Pinho, Mariana Matias, Vanda Marques, Carla Eleutério, Célia Fernandes, Lurdes Gano, Joana D. Amaral, Eduarda Mendes, Maria Jesus Perry, João Nuno Moreira, Gert Storm, Ana Paula Francisco, Cecília M.P. Rodrigues, M. Manuela Gaspar
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114021- (2023)
The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifical
Externí odkaz:
https://doaj.org/article/8bcb887236f344f381f68daa3c7e19f5
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of breast cancer that represents 15–20% of breast tumors and is more prevalent in young pre-menopausal women. It is the subtype of breast cancers with the highest metastatic po
Externí odkaz:
https://doaj.org/article/b55a31c22b41443f9aaa99fa9fbc931e
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 4, Pp 925-940 (2021)
The management of the central nervous system (CNS) disorders is challenging, due to the need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the various strategies that have been studied to circumvent this challenge, the
Externí odkaz:
https://doaj.org/article/bd2493533dc14cd8a499571aca47c86c
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1267 (2022)
Lipid-based nanosystems, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), cationic lipid nanoparticles, nanoemulsions and liposomes, have been extensively studied to improve drug delivery through different administra
Externí odkaz:
https://doaj.org/article/71a04cdfecc449219313d6ed23d55a63
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Nucleolin arises as a relevant target for cancer therapy, as it is overexpressed at the surface of cancer and angiogenic endothelial cells thus enabling a dual cellular targeting strategy. Immunotherapeutic strategies, albeit of proven thera
Externí odkaz:
https://doaj.org/article/1e57d1ee92984485a418010f2f6800b3