Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma

Autor: Joao N. Duarte

Publikováno v: Journal of Ophthalmology, Vol 2021 (2021)

The exact mechanism of retinal ganglion cell loss in the pathogenesis of glaucoma is yet to be understood. Mitochondrial damage-associated molecular patterns (DAMPs) resulting from mitochondrial dysfunction have been linked to Leber’s hereditary op

Externí odkaz: https://doaj.org/article/2db92f00cbc54cb09635933e258f026a

Table S1 from Nanobody–Antigen Conjugates Elicit HPV-Specific Antitumor Immune Responses

Autor: Hidde L. Ploegh, W. Martin Kast, Diane M. Da Silva, Joseph G. Skeate, Justin M. Bader, Joao N. Duarte, Maia Mesyngier, Stephen C. Kolifrath, Mohammad Rashidian, Jingjing Ling, Ross W. Cheloha, Andrew W. Woodham

Supplemental Table 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263c7e39fc6a5b8aec3cc79e205e9811
https://doi.org/10.1158/2326-6066.22540130

Neuronal TNFα, Not α-Syn, Underlies PDD-Like Disease Progression in IFNβ-KO Mice

Autor: Emilie Tresse, Joao N. Duarte, Gisela Jimenez-Duran, Shohreh Issazadeh-Navikas, Oliver Kretz, Desiree Loreth, Tobias Goldmann, Yawei Liu, Erika B Villanueva, Marco Prinz, Patrick Ejlerskov

Publikováno v: Villanueva, E B, Tresse, E, Liu, Y, Duarte, J N, Jimenez-Duran, G, Ejlerskov, P, Kretz, O, Loreth, D, Goldmann, T, Prinz, M & Issazadeh-Navikas, S 2021, ' Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice ', Annals of Neurology, vol. 90, no. 5, pp. 789-807 . https://doi.org/10.1002/ana.26209

OBJECTIVE: Parkinson's disease (PD) manifests in motor dysfunction, non-motor symptoms, and eventual dementia (PDD). Neuropathological hallmarks include nigrostriatal neurodegeneration, Lewy body (LB) pathology, and neuroinflammation. Alpha-synuclein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b55ccc20235ff8195895b406f982c2
https://pubmed.ncbi.nlm.nih.gov/34476836

Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs

Autor: Leo Hanke, Lee Kim Swee, Hidde L. Ploegh, Tao Fang, Juan J. Cragnolini, Jessica R. Ingram, Ali Rashidfarrokhi, Angelina M. Bilate, Justin Bader, Joao N. Duarte, Ariën Schiepers

Publikováno v: The Journal of Immunology. 197:4838-4847

mAbs specific for surface proteins on APCs can serve as Ag-delivery vehicles that enhance immunogenicity. The practical use of such constructs is limited by the challenge of expressing and modifying full-sized mAbs. We generated single-domain Ab frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5470a0504fac630dac58aab1650440
https://doi.org/10.4049/jimmunol.1600692

Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments

Autor: Zeyang Li, Joao N. Duarte, Tao Fang, Roberto Barberena, Christopher S. Theile, Shuji Sato, Hidde L. Ploegh, Guan-Yu Chen, Angelina M. Bilate, Ana M. Avalos

Publikováno v: PMC

Site-specific modification of proteins with fluorophores can render a protein fluorescent without compromising its function. To avoid self-quenching of multiple fluorophores installed in close proximity, we used Holliday junctions to label proteins s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84953c373ebb47ceada831c31932d64a
https://doi.org/10.1002/ange.201505277