Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joao Mokochinski"'
Autor:
Lucy Penfold, Angela Woods, Alice E. Pollard, Julia Arizanova, Eneko Pascual-Navarro, Phillip J. Muckett, Marian H. Dore, Alex Montoya, Chad Whilding, Louise Fets, Joao Mokochinski, Theodora A. Constantin, Anabel Varela-Carver, Damien A. Leach, Charlotte L. Bevan, Alexander Yu. Nikitin, Zoe Hall, David Carling
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112396- (2023)
Summary: Emerging evidence indicates that metabolic dysregulation drives prostate cancer (PCa) progression and metastasis. AMP-activated protein kinase (AMPK) is a master regulator of metabolism, although its role in PCa remains unclear. Here, we sho
Externí odkaz:
https://doaj.org/article/11a6b824917b48fc8d5c5b5a9e0faa99
Autor:
Lucy M.V. Gee, Ben Barron-Millar, Jack Leslie, Claire Richardson, Marco Y.W. Zaki, Saimir Luli, Rachel A. Burgoyne, Rainie I.T. Cameron, Graham R. Smith, John G. Brain, Barbara Innes, Laura Jopson, Jessica K. Dyson, Katherine R.C. McKay, Alexandros Pechlivanis, Elaine Holmes, Rolando Berlinguer-Palmini, Stella Victorelli, George F. Mells, Richard N. Sandford, Jeremy Palmer, John A. Kirby, Christos Kiourtis, Joao Mokochinski, Zoe Hall, Thomas G. Bird, Lee A. Borthwick, Christopher M. Morris, Peter S. Hanson, Diana Jurk, Elizabeth A. Stoll, Fiona E.N. LeBeau, David E.J. Jones, Fiona Oakley
Publikováno v:
Gee, L M V, Barron-Millar, B, Leslie, J, Richardson, C, Zaki, M Y W, Luli, S, Burgoyne, R, Cameron, R I T, Smith, G R, Brain, J G, Innes, B, Jopson, L, Dyson, J K, McKay, K R C, Pechlivanis, A, Holmes, E, Berlinguer-Palmini, R, Victorelli, S, Mells, G F, Sandford, R N, Palmer, J, Kirby, J, Kiourtis, C, Mokochinski, J, Hall, Z, Bird, T G, Borthwick, L A, Morris, C, Hanson, P, Jurk, D, Stoll, E, LeBeau, F, Jones, D & Oakley, F 2022, ' Anti-Cholestatic therapy with Obeticholic Acid improves short term memory in bile duct ligated mice ', The American Journal of Pathology . https://doi.org/10.1016/j.ajpath.2022.09.005
Patients with cholestatic liver disease, including those with primary biliary cholangitis, can experience symptoms of impaired cognition or brain fog. This phenomenon remains unexplained and is currently untreatable. Bile duct ligation (BDL) is an es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70d70f37cc3ec34fd9fc440f82313fc
Autor:
Valeria Amodeo, Timothy Davies, Amalia Martinez-Segura, Melanie P. Clements, Holly Simpson Ragdale, Andrew Bailey, Mariana Silva Dos Santos, James I. MacRae, Joao Mokochinski, Holger Kramer, Claudia Garcia-Diaz, Alex P. Gould, Samuel Marguerat, Simona Parrinello
Glioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting that deregulation of quiescence maintenance may be a prerequisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b141e07ec3c27f17df3741ee017d3854
Autor:
Helen A. B. Paterson, Sijia Yu, Natalia Artigas, Miguel A. Prado, Nejc Haberman, Yi-Fang Wang, Andrew M. Jobbins, Elena Pahita, Joao Mokochinski, Zoe Hall, Maryse Guerin, Joao A. Paulo, Soon Seng Ng, Francesc Villarroya, Sheikh Tamir Rashid, Wilfried Le Goff, Boris Lenhard, Inês Cebola, Daniel Finley, Steven P. Gygi, Christopher R. Sibley, Santiago Vernia
Publikováno v:
Paterson, H, Yu, S, Artigas, N, Prado, M, Haberman, N, Wang, Y-F, Jobbins, A, Pahita, E, Mokochinski, J, Hall, Z, Guerin, M, Paulo, J, Ng, S S, Villarroya, F, Rashid, S T, Goff, W L, Lenhard, B, Cebola, I, Finley, D, Gygi, S, Sibley, C R & Vernia, S 2022, ' Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice ', Nature Metabolism, vol. 4, no. 12, pp. 1812-1829 . https://doi.org/10.1038/s42255-022-00681-y
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15b0846709fc330dbcd9cb12a59260e
https://hdl.handle.net/20.500.11820/eecc8061-8675-4351-a1e0-503b0c53cf98
https://hdl.handle.net/20.500.11820/eecc8061-8675-4351-a1e0-503b0c53cf98
Autor:
Valeria Amodeo, Timothy Davies, Amalia Martinez-Segura, Melanie Clements, Holly Simpson Ragdale, Andrew Bailey, Mariana Silva Dos Santos, James I. MacRae, Joao Mokochinski, Holger Kramer, Claudia Garcia-Diaz, Alex P. Gould, Samuel Marguerat, Simona Parrinello
SummaryGlioblastoma is thought to originate from neural stem cells (NSCs) of the subventricular zone that acquire genetic alterations. In the adult brain, NSCs are largely quiescent, suggesting that deregulation of quiescence maintenance may be a pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a1013719b6b7ba1a68c906868d1232d
https://doi.org/10.1101/2022.03.09.483611
https://doi.org/10.1101/2022.03.09.483611