Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Joao M. Braz"'
Autor:
Stefan Gahbauer, Chelsea DeLeon, Joao M. Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B. Billesbølle, Yongfeng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A. Fink, Ivan S. Kondratov, Yurii S. Moroz, John J. Irwin, Allan I. Basbaum, Bryan L. Roth, Brian K. Shoichet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting prostagl
Externí odkaz:
https://doaj.org/article/5afef5b1703241589164379113e645d4
Autor:
Xiaobing Yu, Hongju Liu, Katherine A. Hamel, Maelig G. Morvan, Stephen Yu, Jacqueline Leff, Zhonghui Guan, Joao M. Braz, Allan I. Basbaum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Interactions among spinal dorsal horn neurons and microglia contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury. The authors show that depletion of macrophages in the dorsal root ganglia prevents and reverses
Externí odkaz:
https://doaj.org/article/0d2d77d7fa8e4d94b8e034d798ce04f1
Publikováno v:
PAIN Reports, Vol 3, Iss 4, p e659 (2018)
Abstract. Introduction:. Gabapentin regulates pain processing by direct action on primary afferent nociceptors and dorsal horn nociresponsive neurons. Through an action at supraspinal levels, gabapentin also engages descending noradrenergic inhibitor
Externí odkaz:
https://doaj.org/article/b9417b10d68b473583e28ef913dcde6e
Autor:
Hugues Petitjean, Sophie Anne Pawlowski, Steven Li Fraine, Behrang Sharif, Doulia Hamad, Tarheen Fatima, Jim Berg, Claire M. Brown, Lily-Yeh Jan, Alfredo Ribeiro-da-Silva, Joao M. Braz, Allan I. Basbaum, Reza Sharif-Naeini
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1246-1257 (2015)
Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal h
Externí odkaz:
https://doaj.org/article/7ba324e14c0d481c8a4aebb403525f60
Publikováno v:
eLife, Vol 11 (2022)
TRPV1, a capsaicin- and heat-activated ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain conditions. Although pharmacological modulation of TRPV1 has attracted therapeutic interes
Externí odkaz:
https://doaj.org/article/3ccf0b0584f549048db5a0346a74fce0
Autor:
Line S Löken, Joao M Braz, Alexander Etlin, Mahsa Sadeghi, Mollie Bernstein, Madison Jewell, Marilyn Steyert, Julia Kuhn, Katherine Hamel, Ida J Llewellyn-Smith, Allan Basbaum
Publikováno v:
eLife, Vol 10 (2021)
Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages. Using a tamoxifen-inducible CalcaCreER transgenic mouse, here we ide
Externí odkaz:
https://doaj.org/article/fb40c08c940e4f84a41354a824652ad0
Autor:
Jarret AP Weinrich, Cindy D Liu, Madison E Jewell, Christopher R Andolina, Mollie X Bernstein, Jorge Benitez, Sian Rodriguez-Rosado, Joao M Braz, Mervyn Maze, Mikhail I Nemenov, Allan I Basbaum
The general consensus is that increases in neuronal activity in the anterior cingulate cortex (ACC) contribute to pain’s negative affect. Here, usingin vivoimaging of neuronal calcium dynamics in mice, we report that nitrous oxide, a general anesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8738aa9dedfbf90bd5aa2305c957a92
https://doi.org/10.1101/2023.04.03.534475
https://doi.org/10.1101/2023.04.03.534475
Autor:
Tia A. Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M. Braz, Evan S. O’Brien, Reed M. Stein, Veronica Craik, Ngan K. Tran, Suthakar Ganapathy, Yuki Shiimura, Fei Tong, Thanh C. Ho, Dmytro S. Radchenko, Yurii S. Moroz, Fangyu Liu, Sian Rodriguez Rosado, Karnika Bhardwaj, Jorge Benitez, Yongfeng Liu, Herthana Kandasamy, Claire Normand, Meriem Semache, Laurent Sabbagh, Isabella Glenn, John J. Irwin, Kaavya Krishna Kumar, Alexandros Makriyannis, Allan I. Basbaum, Brian K. Shoichet
Docking tangible virtual libraries can reveal unexpected chemotypes that complement the structures of biological targets. Seeking new agonists for the cannabinoid-1 receptor (CB1R), we docked 74 million tangible molecules, prioritizing 46 high rankin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f866fdd249e0ce3cd2d9772403b5cafc
https://doi.org/10.1101/2023.02.27.530254
https://doi.org/10.1101/2023.02.27.530254
Autor:
Assaf Alon, Jiankun Lyu, Joao M. Braz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara, Chase M. Webb, Dmytro S. Radchenko, Yurii S. Moroz, Xi-Ping Huang, Yongfeng Liu, Bryan L. Roth, John J. Irwin, Allan I. Basbaum, Brian K. Shoichet, Andrew C. Kruse
Publikováno v:
Nature
Nature, vol 600, iss 7890
Nature, vol 600, iss 7890
The σ(2) receptor has attracted intense interest in cancer imaging(1), psychiatric disease(2), neuropathic pain(3–5), and other areas of biology(6,7). We determined the crystal structure of this receptor in complex with the clinical candidate rolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3233504cbae460083347e7517b83e1c9
https://doi.org/10.1038/s41586-021-04175-x
https://doi.org/10.1038/s41586-021-04175-x
Autor:
Elissa A. Fink, Jun Xu, Harald Hübner, Joao M. Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothee Weikert, Maximilian F. Schmidt, Chase M. Webb, Nataliya A. Tolmachova, Yurii S. Moroz, Xi-Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P. Jacobson, John J. Irwin, Michel Bouvier, Yang Du, Brian K. Shoichet, Allan I. Basbaum, Peter Gmeiner
Publikováno v:
Science. 377
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α 2A -adrenergic receptor (α 2A AR), seeking new α 2A AR agonists chemotypes that lack the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8d0d773df6654433617ced8c92103ff
https://doi.org/10.1126/science.abn7065
https://doi.org/10.1126/science.abn7065