Výsledky vyhledávání - "Joao C, Guimaraes"

Akademický článek

A rare codon-based translational program of cell proliferation

Autor: Joao C. Guimaraes, Nitish Mittal, Alexandra Gnann, Dominik Jedlinski, Andrea Riba, Katarzyna Buczak, Alexander Schmidt, Mihaela Zavolan

Publikováno v: Genome Biology, Vol 21, Iss 1, Pp 1-20 (2020)

Abstract Background The speed of translation elongation is primarily determined by the abundance of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are translated. As the nature of tRNA pools and modifications can vary ac

Externí odkaz: https://doaj.org/article/0a1ea9e16881465188f2321c2b3c23a0

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Akademický článek

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Autor: Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and s

Externí odkaz: https://doaj.org/article/314fcd580797451983c726cd599eaae1

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Akademický článek

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

Autor: Nitish Mittal, Joao C. Guimaraes, Thomas Gross, Alexander Schmidt, Arnau Vina-Vilaseca, Danny D. Nedialkova, Florian Aeschimann, Sebastian A. Leidel, Anne Spang, Mihaela Zavolan

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout,

Externí odkaz: https://doaj.org/article/b6439a80872547a384d1bede0c79d78b

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Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

Autor: Ryoko Okamoto, Luigi Terracciano, Mohamed Bentires-Alj, Marcel P. Trefny, Marcus Vetter, Alfred Zippelius, Joao C. Guimaraes, Walter P. Weber, Katrin Volkmann, Christian Kurzeder, Duvini De Silva, Ana Luísa Correia, Alexander Schmidt, Kirsten D. Mertz, Sandro Bruno, Priska Auf der Maur

The persistence of undetectable disseminated tumour cells (DTCs) after primary tumour resection poses a major challenge to effective cancer treatment1–3. These enduring dormant DTCs are seeds of future metastases, and the mechanisms that switch the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5605845bcb14053a69e34fe5b09cd7
https://edoc.unibas.ch/90861/

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Prevention of dsRNA-induced interferon signaling by AGO1x is linked to breast cancer cell proliferation

Autor: Ana Luísa Correia, Alexander Schmidt, Mihaela Zavolan, Joao C. Guimaraes, Anastasiya Börsch, Sébastien Pfeffer, Luigi Terracciano, Gunter Meister, Salvatore Piscuoglio, Thomas Montavon, Souvik Ghosh, Johannes Danner, Nitish Mittal, Beatrice Dimitriades, Afzal Pasha Syed, Shreemoyee Ghosh, Manuela Lanzafame

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (18), ⟨10.15252/embj.2019103922⟩
The EMBO Journal

Translational readthrough, i.e., elongation of polypeptide chains beyond the stop codon, was initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in proteome diversification and protein‐level modulation. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47e999d1f62c666eb1f8b17ba27ab32
https://hal.archives-ouvertes.fr/hal-02954154/document

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A rare codon-based translational program of cell proliferation

Autor: Alexander Schmidt, Joao C. Guimaraes, Katarzyna Buczak, Alexandra Gnann, Andrea Riba, Nitish Mittal, Mihaela Zavolan, Dominik J. Jedlinski

Publikováno v: Genome Biology, Vol 21, Iss 1, Pp 1-20 (2020)
Genome Biology
Genome Biology, 2020, 21 (1), ⟨10.1186/s13059-020-1943-5⟩

Background The speed of translation elongation is primarily determined by the abundance of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are translated. As the nature of tRNA pools and modifications can vary across biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85adc375f83a069aed4cd0de826ec68b
https://edoc.unibas.ch/76093/

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